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Microbial Signaling Compounds as Endocrine Effectors

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Microbial Endocrinology

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Abstract

The major focus of this book is how chemical signals, including classic hormones, produced by the mammalian endocrine system alter the behavior of microbes residing in the host. However, it is also apparent that residential and transient microbes also produce signals within a host and that these signals are incorporated into the chemical milieu shared by mammalian and microbial cells. Therefore, this chapter explores the possibility that microbe-derived chemicals can transmit signals to host cells and alter host-cell behavior. We define the properties expected of a cross-kingdom signal, citing specific examples from the plethora of metabolites, toxins, second messengers, and other small chemicals produced by microbes. Furthermore, we describe published evidence of the potential physiological effects of microbial signals on host cells. In keeping with the classic model of endocrine signaling, we also discuss potential microbial signal–mammalian receptor interactions. Thus, this chapter extends the concept of Microbial Endocrinology by highlighting the bidirectional nature of signal exchange between host and microbe in the human microbiome, a concept termed interkingdom signaling.

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Authors and Affiliations

  1. Department of Cell Biology and Biochemistry, Texas Tech University Health Sciences Center, 3601 4th Street, MS 6540, Lubbock, TX, 79430, USA

    Aruna Jahoor & Simon Williams (Associate Professor)

  2. Department of Surgery, Texas Tech University Health Sciences Center, 3601 4th Street, Lubbock, Texas, 79430, USA

    Kendra Rumbaugh

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  1. Aruna Jahoor
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  2. Simon Williams
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  3. Kendra Rumbaugh
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Correspondence to Kendra Rumbaugh .

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  1. Health Sciences Center, School of Pharmacy, Texas Tech University, 4th Street 3601, Lubbock, 79430, USA

    Mark Lyte

  2. School of Medicine, Dept. Infection, Immunity & Inflammation, University of Leicester, Leicester, United Kingdom

    Primrose P.E. Freestone

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Jahoor, A., Williams, S., Rumbaugh, K. (2010). Microbial Signaling Compounds as Endocrine Effectors. In: Lyte, M., Freestone, P. (eds) Microbial Endocrinology. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-5576-0_14

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