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Pathophysiology of Vascular Disease

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Peripheral Endovascular Interventions

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Abstract

Vascular disease is the major cause of morbidity and mortality in Western civilization. Its manifestations include heart attacks, strokes, lower extremity occlusive disease, and aneurysmal disease, and its predominant underlying cause is atherosclerosis. Although atherosclerosis is a generalized disorder of the arterial tree associated with well-known risk factors—including hyperlipidemia, hypertension, cigarette smoking, and diabetes mellitus—its clinical expression tends to be focal. Not all individuals with extensive risk factors develop atherosclerotic plaques, and many patients with extensive atherosclerotic plaques have no recognized risk factors. Moreover, morbidity and mortality usually result from localized plaque deposition at certain vulnerable sites in the arterial tree rather than from diffuse disease.

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Authors and Affiliations

  1. Department of Surgery, Stanford University School of Medicine, Stanford, CA, USA

    Christopher K. Zarins MD (Professor) & Chengpei Xu MD (Senior Research Scientist)

  2. Department of Pathology, The University of Chicago, Chicago, IL, USA

    Seymour Glagov MD (Professor Emeritus of Pathology and Surgery)

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  1. Christopher K. Zarins MD
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  2. Chengpei Xu MD
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  3. Seymour Glagov MD
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  1. Alpine Road 3270, Portola Valley, 94028, California, USA

    Thomas J. Fogarty

  2. Harbor-UCLA Medical Center, W. Carson St. 1000, Torrance, 90509, California, USA

    Rodney A. White

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Zarins, C.K., Xu, C., Glagov, S. (2010). Pathophysiology of Vascular Disease. In: Fogarty, T., White, R. (eds) Peripheral Endovascular Interventions. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-1387-6_2

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