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Tissue-Specific Tumour Suppression byAPC

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APC Proteins

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 656))

Abstract

One question that has been central to the study of the Apc gene is why the Apc gene ismutated so frequently in colorectal cancer but relatively infrequently in other tumour types. This chapter reviews recent data obtained in mice after conditional deletion of both copies of the Apc gene from adult epithelial tissues with particular focus on the intestinal epithelium. These data suggest that a major reason for the frequent mutation of Apc in colorectal cancer lies in the distinct character of the intestinal epithelium where Apc loss leads to a progenitor-like phenotype. Thus intestinal enterocytes lacking Apc escape the two major selective constraints that usually prevent cells from becoming cancerous in the intestine: they fail to differentiate and fail to migrate so are not sloughed off into the intestinal lumen.

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Author information

Authors and Affiliations

  1. Beaton Institute of Cancer Research, Glasgow, G61 1BD, UK

    Owen Sansom

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  1. Owen Sansom
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Correspondence to Owen Sansom .

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Editors and Affiliations

  1. Cell and Developmental Biology, College of Life Sciences, University of Dundee, Dundee, Scotland, UK

    Inke S. Näthke

  2. Department of Biological Sciences, Carnegie Mellon University, Pittsburgh, Pennsylvania, USA

    Brooke M. McCartney

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© 2009 Landes Bioscience and Springer Science+Business Media

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Sansom, O. (2009). Tissue-Specific Tumour Suppression byAPC. In: Näthke, I.S., McCartney, B.M. (eds) APC Proteins. Advances in Experimental Medicine and Biology, vol 656. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-1145-2_9

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