Abstract
In Chapter 4, we gave a brief introduction to proteins. The structures of a very large number of proteins have been determined and it is possible to ask fundamental questions: Given the primary sequence, what is tertiary structure? How does the protein fold into the final structure? This “folding problem” has attracted a great deal of attention, and it has become an industry. (One of the Web search engines has more than 106 entries.) We will not treat the folding problem here, but refer to review articles for more information [1]–[7]. Here we discuss a simpler problem, how the main secondary structures, ?-helices and ? pleated sheets , combine to form globular proteins. The folding problem is also treated in Section 17.3.
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Frauenfelder, H. (2010). Tertiary Structure of Proteins. In: Chan, S., Chan, W. (eds) The Physics of Proteins. Biological and Medical Physics, Biomedical Engineering. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-1044-8_9
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DOI: https://doi.org/10.1007/978-1-4419-1044-8_9
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