Abstract
Charges are essential for the stability and function of many proteins. To understand the effect of the environment, particularly its pH on stability and function, a few concepts are needed.
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References
G. Adam, P. Läuger, and G. Stark. Physikalische Chemie und Biophysik, 5. Aufl. Springer, Berlin, 2009.
The correct definition of pH involves the concept of activity (I. M. Klotz and R. M. Rosenberg, Chemical Thermodynamics, W. A. Benjamin, Menlo Park, 1972). For details, see, for instance, R. G. Bates, Determination of pH: Theory and Practice, Wiley, New York, 1973.
C. Tanford. Physical Chemistry of Macromolecules. Wiley, New York, 1961.
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Frauenfelder, H. (2010). Acids and Bases for Physicists. In: Chan, S., Chan, W. (eds) The Physics of Proteins. Biological and Medical Physics, Biomedical Engineering. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-1044-8_19
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DOI: https://doi.org/10.1007/978-1-4419-1044-8_19
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