Skip to main content

Myocardial Viability

  • Chapter
  • First Online:
Clinical PET and PET/CT
  • 2710 Accesses

Abstract

Ischemic heart disease is the most common cause of heart failure. For the treatment of heart failure, medical treatment, heart transplantation, and revascularization can be a therapeutic method (Challapalli S, Bonow RO, Gheorghiade M. Coron Artery Dis 9:659–674, 1998). Because of the ease of the procedure and good therapeutic performance, revascularization has been widely used in ischemic heart disease (Alderman EL, Corley SD, Fisher LD, Chaitman BR, Faxon DP, Foster ED, Killip T, Sosa JA, Bourassa MG. J Am Coll Cardiol 22(4):1141–1154, 1993). However, revascularization has a substantial degree of risk associated with the procedure, especially in patients with severe heart failure, and heart function is recovered only in some of the patients who undergo revascularization (Schinkel AF, Poldermans D, Vanoverschelde JL, Elhendy A, Boersma E, Roelandt JR, et al. Am J Cardiol 93:14–17, 2004).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

eBook
USD 16.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Challapalli S, Bonow RO, Gheorghiade M. Medical management of heart failure secondary to coronary artery disease. Coron Artery Dis. 1998;9:659–74.

    PubMed  CAS  Google Scholar 

  2. Alderman EL, Corley SD, Fisher LD, Chaitman BR, Faxon DP, Foster ED, Killip T, Sosa JA, Bourassa MG. Five-year angiographic follow-up of factors associated with progression of coronary artery disease in the Coronary Artery Surgery Study (CASS) CASS Participating Investigators and Staff. J Am Coll Cardiol. 1993;22(4):1141–54.

    Article  PubMed  CAS  Google Scholar 

  3. Schinkel AF, Poldermans D, Vanoverschelde JL, Elhendy A, Boersma E, Roelandt JR, et al. Incidence of recovery of contractile function following revascularization in patients with ischemic left ventricular dysfunction. Am J Cardiol. 2004;93:14–7.

    Article  PubMed  Google Scholar 

  4. Maes A, Flameng W, Nuyts J, Borgers M, Shivalkar B, Ausma J, et al. Histological alterations in chronically hypoperfused myocardium. Correlation with PET findings. Circulation. 1994;90:735–45.

    Article  PubMed  CAS  Google Scholar 

  5. Rahimtoola SH. The hibernating myocardium. Am Heart J. 1989;117:211–21.

    Article  PubMed  CAS  Google Scholar 

  6. Braunwald E, Kloner RA. The stunned myocardium: prolonged, postischemic ventricular dysfunction. Circulation. 1982;66:1146–9.

    Article  PubMed  CAS  Google Scholar 

  7. Bolli R. Myocardial ‘stunning’ in man. Circulation. 1992;86(6):1671–91.

    Article  PubMed  CAS  Google Scholar 

  8. Vanoverschelde JL, Melin JA. The pathophysiology of myocardial hibernation: current controversies and future directions. Prog Cardiovasc Dis. 2001;43:387–98.

    Article  PubMed  CAS  Google Scholar 

  9. Bax JJ, van der Wall EE, Harbinson M. Radionuclide techniques for the assessment of myocardial viability and hibernation. Heart. 2004;90(Suppl 5):v26–33.

    Article  PubMed  Google Scholar 

  10. Bax JJ, Poldermans D, Elhendy A, Boersma E, Rahimtoola SH. Sensitivity, specificity, and predictive accuracies of various noninvasive techniques for detecting hibernating myocardium. Curr Probl Cardiol. 2001;26:147–86.

    Article  PubMed  CAS  Google Scholar 

  11. Bax JJ, Maddahi J, Poldermans D, Elhendy A, Cornel JH, Boersma E, et al. Sequential (201)Tl imaging and dobutamine echocardiography to enhance accuracy of predicting improved left ventricular ejection fraction after revascularization. J Nucl Med. 2002;43(6):795–802.

    PubMed  Google Scholar 

  12. Samady H, Elefteriades JA, Abbott BG, Mattera JA, McPherson CA, Wackers FJ. Failure to improve left ventricular function after coronary revascularization for ischemic cardiomyopathy is not associated with worse outcome. Circulation. 1999;100:1298–304.

    Article  PubMed  CAS  Google Scholar 

  13. Marwick TH, Zuchowski C, Lauer MS, Secknus MA, Williams J, Lytle BW. Functional status and quality of life in patients with heart failure undergoing coronary bypass surgery after assessment of myocardial viability. J Am Coll Cardiol. 1999;33:750–8.

    Article  PubMed  CAS  Google Scholar 

  14. Dilsizian V, Bonow RO. Current diagnostic techniques of assessing myocardial viability in patients with hibernating and stunned myocardium. Circulation. 1993;87:1–20.

    Article  PubMed  CAS  Google Scholar 

  15. Bonow RO, Dilsizian V. Thallium-201 and technetium-99 m-sestamibi for assessing viable myocardium. J Nucl Med. 1992;33:815–8.

    PubMed  CAS  Google Scholar 

  16. Sciagrà R, Pellegri M, Pupi A, Bolognese L, Bisi G, Carnovale V, Santoro GM. Prognostic implications of Tc-99 m sestamibi viability imaging and subsequent therapeutic strategy in patients with chronic coronary artery disease and left ventricular dysfunction. J Am Coll Cardiol. 2000;36:739–45.

    Article  PubMed  Google Scholar 

  17. King LM, Opie LH. Glucose delivery is a major determinant of glucose utilisation in the ischemic myocardium with a residual coronary flow. Cardiovasc Res. 1998;39:381–92.

    Article  PubMed  CAS  Google Scholar 

  18. Gropler RJ. Methodology governing the assessment of myocardial glucose metabolism by positron emission tomography and fluorine 18-labeled fluorodeoxyglucose. J Nucl Cardiol. 1994;1:S4–14.

    Article  PubMed  CAS  Google Scholar 

  19. Knuuti MJ, Yki-Järvinen H, Voipio-Pulkki LM, Mäki M, Ruotsalainen U, Härkönen R, et al. Enhancement of myocardial [fluorine-18]fluorodeoxyglucose uptake by a nicotinic acid derivative. J Nucl Med. 1994;35:989–98.

    PubMed  CAS  Google Scholar 

  20. Bax JJ, Patton JA, Poldermans D, Elhendy A, Sandler MP. 18-Fluorodeoxyglucose imaging with positron emission tomography and single photon emission computed tomography: cardiac applications. Semin Nucl Med. 2000;30:281–98.

    Article  PubMed  CAS  Google Scholar 

  21. Di Carli MF, Davidson M, Little R, Khanna S, Mody FV, Brunken RC, et al. Value of metabolic imaging with positron emission tomography for evaluating prognosis in patients with coronary artery disease and left ventricular dysfunction. Am J Cardiol. 1994;73:527–33.

    Article  PubMed  Google Scholar 

  22. Maddahi J, Schelbert H, Brunken R, Di Carli M. Role of thallium-201 and PET imaging in evaluation of myocardial viability and management of patients with coronary artery disease and left ventricular dysfunction. J Nucl Med. 1994;35:707–15.

    PubMed  CAS  Google Scholar 

  23. Allman KC, Shaw LJ, Hachamovitch R, Udelson JE. Myocardial viability testing and impact of revascularization on prognosis in patients with coronary artery disease and left ventricular dysfunction: a meta-analysis. J Am Coll Cardiol. 2002;39:1151–8.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Won Jun Kang M.D., Ph.D. .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2013 Springer Science+Business Media New York

About this chapter

Cite this chapter

Kang, W.J. (2013). Myocardial Viability. In: Kim, E., Lee, MC., Inoue, T., Wong, WH. (eds) Clinical PET and PET/CT. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-0802-5_20

Download citation

  • DOI: https://doi.org/10.1007/978-1-4419-0802-5_20

  • Published:

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4419-0801-8

  • Online ISBN: 978-1-4419-0802-5

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics