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Surgical Left Ventricular Remodeling Procedures

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Computational Cardiovascular Mechanics

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Abstract

Perhaps the most straightforward clinical application of validated regional ventricular mechanics models for diseased hearts is the simulation of a novel surgical procedure or medical device for treating heart failure or ischemic cardiomyopathy. In each study our cardiac biomechanics laboratory uses one of two different approaches: (1) an axisymmetric truncated ellipsoidal model with left ventricular (LV) cavity and wall volumes typical of the failing human heart or animal model of heart failure to determine efficacy of the surgical procedure or device; or (2) an animal- or patient-specific fully 3-D model of the infarcted LV created using echocardiography or MRI to optimize the design of the surgical procedure or device. This chapter is concerned with brief descriptions of the studies from our laboratory that provide the best examples of these two approaches.

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Acknowledgments

This research was supported by National Institutes of Health grants 5R01 HL077921 and HL086400 (Dr. Guccione) and 5R01 HL063348 (Dr. Ratcliffe).

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Authors and Affiliations

  1. Department of Surgery, University of California at San Francisco and San Francisco VA Medical Center, San Francisco, CA, USA

    Jonathan F. Wenk, Choon-Sik Jhun, Kay Sun, Mark B. Ratcliffe & Julius M. Guccione

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  1. Jonathan F. Wenk
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  2. Choon-Sik Jhun
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  3. Kay Sun
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  4. Mark B. Ratcliffe
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  5. Julius M. Guccione
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Corresponding author

Correspondence to Julius M. Guccione .

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Editors and Affiliations

  1. Veterans Affairs Medical Center, University of California, San Francisco, Clement St. 4150, San Francisco, 94121, U.S.A.

    Julius M. Guccione

  2. Purdue University Indianapolis, Indiana University, Barnhill Drive 635, Indianapolis, 46202, U.S.A.

    Ghassan S. Kassab

  3. Veterans Affairs Medical Center, University of California, San Francisco, Clement St. 4150, San Francisco, 94121, U.S.A.

    Mark B. Ratcliffe

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Wenk, J.F., Jhun, CS., Sun, K., Ratcliffe, M.B., Guccione, J.M. (2010). Surgical Left Ventricular Remodeling Procedures. In: Guccione, J., Kassab, G., Ratcliffe, M. (eds) Computational Cardiovascular Mechanics. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-0730-1_12

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  • DOI: https://doi.org/10.1007/978-1-4419-0730-1_12

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  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4419-0729-5

  • Online ISBN: 978-1-4419-0730-1

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