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Noninvasive Assessment of Left Ventricular Remodeling: Geometry, Wall Stress, and Function

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Computational Cardiovascular Mechanics

Abstract

Left ventricular (LV) remodeling after myocardial infarction (MI) plays an important role in the progression of heart failure (HF). Changes in the shape, size, and function of the LV are caused by altered mechanical properties of the injured myocardium. As the survival rate after MI improves with medical advances, the incidence of HF patients increases. Hence, an accurate depiction of the LV remodeling process facilitates disease surveillance and monitoring of therapeutic efficacy. It may also help determine the choice of treatment, e.g., surgery to remove the infarcted wall segment and reduce the LV cavity size. Traditionally, there are several ways of characterizing LV remodeling: changes in LV diameter, LV volume, ejection fraction, and qualitative or semi-quantitative descriptors of LV shape. In this chapter, we present a new approach to quantify LV shape (in terms of curvedness), wall stress, and function by using computational modeling.

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Acknowledgments

This research was supported in part by National Heart Centre Research Grant and the National Institute of Health – National Heart, Lung, and Blood Institute Grant HL84529 and 2R01HL055554-11.

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Authors and Affiliations

  1. Department of Cardiology, National Heart Centre Singapore, Singapore, Singapore

    Liang Zhong, Ru San Tan, Terrace Chua & Tian Hai Koh

  2. Institute of High Performance Computing, Agency for Science, Technology and Research, Singapore, Singapore

    Yi Su

  3. School of Engineering, University of Swansea, Swansea, UK

    Si Yong Yeo

  4. Parkway College, 150168, Singapore, Singapore

    Dhanjoo Ghista

  5. Weldon School of Biomedical Engineering, Purdue University, 47906, West Lafayette, IN, USA

    Ghassan Kassab

  6. Department of Biomedical Engineering Department of Surgery Department of Cellular and Integrative Physiology Indiana Center for Vascular Biology and Medicine, IUPUI, 46202, Indianapolis, IN, USA

    Ghassan Kassab

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  1. Liang Zhong
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Corresponding author

Correspondence to Liang Zhong .

Editor information

Editors and Affiliations

  1. Veterans Affairs Medical Center, University of California, San Francisco, Clement St. 4150, San Francisco, 94121, U.S.A.

    Julius M. Guccione

  2. Purdue University Indianapolis, Indiana University, Barnhill Drive 635, Indianapolis, 46202, U.S.A.

    Ghassan S. Kassab

  3. Veterans Affairs Medical Center, University of California, San Francisco, Clement St. 4150, San Francisco, 94121, U.S.A.

    Mark B. Ratcliffe

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Zhong, L. et al. (2010). Noninvasive Assessment of Left Ventricular Remodeling: Geometry, Wall Stress, and Function. In: Guccione, J., Kassab, G., Ratcliffe, M. (eds) Computational Cardiovascular Mechanics. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-0730-1_11

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  • DOI: https://doi.org/10.1007/978-1-4419-0730-1_11

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  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4419-0729-5

  • Online ISBN: 978-1-4419-0730-1

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