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TGF-β Signaling Alterations in Neoplastic and Stromal Cells

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Cancer Genome and Tumor Microenvironment

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Abstract

Transforming growth factor beta (TGF-β) plays an central role in cell homeostasis and inherited mutations in the TGFB1 gene cause Camurati-Engelmann disease, a condition characterized by hyperostosis and sclerosis of the diaphyses of long bones (Janssens et al., 2000; Kinoshita et al., 2000). However, mutations in the TGFB genes do not appear to occur in cancer. In contrast, type I and II TGF-β receptors and their downstream effectors SMADs are often targeted by oncogenic events.

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Acknowledgments

Supported by grants from CA112520, CA108741 from the NCI and AR048098-070007 from the NIH.

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  1. Division of Hematology/Oncology, Department of Medicine and UAB Comprehensive Cancer Center, The University of Alabama at Birmingham, Birmingham, Al, USA

    Qinghua Zeng & Boris Pasche

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  1. Qinghua Zeng
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  1. Children's Hospital of Philadelphia, Civic Center Blvd. 3615, Philadelphia, 19104, U.S.A.

    Andrei Thomas-Tikhonenko

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Zeng, Q., Pasche, B. (2010). TGF-β Signaling Alterations in Neoplastic and Stromal Cells. In: Thomas-Tikhonenko, A. (eds) Cancer Genome and Tumor Microenvironment. Cancer Genetics. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-0711-0_15

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