Periampullary adenocarcinomas arise within 2 cm of the major papilla in the duodenum. They arise from different tissues in the periampullary region: the head/neck/uncinate process of the pancreas, the distal common bile duct, the duodenum, and the ampulla of Vater. Pancreatic cancer is the most common periampullary adenocarcinoma, followed by distal bile duct cancers, ampullary cancers, and duodenal cancers (Jemal et al., 2007). There are an estimated 40,000 incident cases of periampullary cancer annually in the United States with pancreatic cancer accounting for over 33,000 cases annually (Jemal et al., 2007). The overall 5-year survival for all patients with pancreatic cancer is > 5%.
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Bowen, K.A., Riall, T.S. (2008). Periampullary Adenocarcinoma: Diagnosis and Survival After Pancreaticoduodenectomy. In: Hayat, M.A. (eds) Gastrointestinal Carcinoma. Methods of Cancer Diagnosis, Therapy, and Prognosis, vol 3. Springer, Dordrecht. https://doi.org/10.1007/978-1-4020-8900-8_21
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