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Low Dose Hyper-Radiosensitivity: A Historical Perspective

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Targeted Radionuclide Tumor Therapy

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Summary

This chapter discusses the biology of low-dose hyper-radiosensitivity (HRS) with reference to radiation-induced DNA damage and cellular repair processes. Particular attention is paid to the significance of G2-phase cell cycle check-points in overcoming low-dose hyper-radiosensitivity and the impact of HRS on low-dose rate radiobiology. The history of HRS from the original in vivo discovery to the most recent in vitro and clinical data are examined to present a unifying hypothesis concerning the molecular control and regulation of this important low-dose radiation response. Finally, pre-clinical and clinical data are discussed, from a molecular viewpoint, to provide theoretical approaches to exploit HRS biology for clinical gain.

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Authors and Affiliations

  1. Department of Radiation Oncology, William Beaumont Hospital, 3811 W. Thirteen Mile Road, 105-RI, Royal Oak, MI, 48073-0213, USA

    Brian Marples & Sarah A. Krueger

  2. DNA Damage Response Laboratory, Cancer Research UK, Clare Hall Laboratories, Blanche Lane, South Mimms, EN6 3LD, UK

    Spencer J. Collis

  3. Department of Radiation Oncology, Wayne State University, Gershenson Radiation Oncology Center, 4100 John R, Detroit, MI, 48201-2013, USA

    Michael C. Joiner

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Editors and Affiliations

  1. Department of Immunology, University of Umea, Umea, Sweden

    Torgny Stigbrand

  2. Rudbeck Laboratory, Uppsala University, Uppsala, Sweden

    Jörgen Carlsson

  3. Department of Medical Oncology, Fox Chase Cancer Center, Philadelphia, USA

    Gregory P. Adams

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Marples, B., Krueger, S.A., Collis, S.J., Joiner, M.C. (2008). Low Dose Hyper-Radiosensitivity: A Historical Perspective. In: Stigbrand, T., Carlsson, J., Adams, G.P. (eds) Targeted Radionuclide Tumor Therapy. Springer, Dordrecht. https://doi.org/10.1007/978-1-4020-8696-0_19

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