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Radiation Induced DNA Damage Checkpoints

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Targeted Radionuclide Tumor Therapy

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Summary

Radiation induced damage to DNA can be limited to exchanges of single DNA bases or extensive double-strand breaks. Nuclear proteins can sense these alterations and are able to cause cell cycle arrests at the G1/S, intra-S or G2/M checkpoints in the cell cycle, until the lesions undergo repair. If the induction of these cell cycle arrests is defective, genomic instability and aberrations in the cell cycle kinetics appear, which may cause cell death. In this chapter radiation induced effects on the cell cycle will be presented.

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Authors and Affiliations

  1. Departments of Immunology, Diagnostic Radiology and Radiophysics, University of Umeå, SE-90185, Umeå, Sweden

    David Eriksson, Katrine Riklund, Lennart Johansson & Torgny Stigbrand

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  1. David Eriksson
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  2. Katrine Riklund
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  3. Lennart Johansson
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  4. Torgny Stigbrand
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Editors and Affiliations

  1. Department of Immunology, University of Umea, Umea, Sweden

    Torgny Stigbrand

  2. Rudbeck Laboratory, Uppsala University, Uppsala, Sweden

    Jörgen Carlsson

  3. Department of Medical Oncology, Fox Chase Cancer Center, Philadelphia, USA

    Gregory P. Adams

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Eriksson, D., Riklund, K., Johansson, L., Stigbrand, T. (2008). Radiation Induced DNA Damage Checkpoints. In: Stigbrand, T., Carlsson, J., Adams, G.P. (eds) Targeted Radionuclide Tumor Therapy. Springer, Dordrecht. https://doi.org/10.1007/978-1-4020-8696-0_14

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