Abstract
Living cells are auto-dynamic because of control systems operating in their periodic mode. They comprise diverse regulatory networks and are thus multi-oscillators covering a wide range of characteristics. Phosphorylation reactions are involved in virtually all aspects of cell function. Here, we outline a range of our studies on ATP and protein phosphorylation in order to highlight certain features of ultradian dynamics not widely recognised nor appreciated. Our work in this field alone supports the multi-oscillator concept of the living cell and confirms its complexities not least with regard to the significance of temporal oganisation of dynamic processes. The findings support the view that the regulation of cell function, properties and behaviour is achieved through modulation of the dynamic characteristics and are consistent with our concepts of differentiation and cancer.
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Gilbert, D.A., Hammond, K.D. (2008). Phosphorylation Dynamics in Mammalian Cells. In: Lloyd, D., Rossi, E.L. (eds) Ultradian Rhythms from Molecules to Mind. Springer, Dordrecht. https://doi.org/10.1007/978-1-4020-8352-5_4
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