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Abnormal variation of the immune response as related to cancer

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Selected Aspects of Cancer Progression: Metastasis, Apoptosis and Immune Response

Part of the book series: Cancer Growth and Progression ((CAGP,volume 11))

Abstract

This overview chapter reviews the complex interrelationship between the immune system, cell proliferation and cancer. There exist, in essence, two opposite actions of the immune system with regard to tumor development: immune suppression of neoplasia (commonly: immune surveillance) and immune stimulation of tumor growth. In addition, there exists experimental evidence that certain tumors of the immune system itself (e.g. malignant lymphomas) may be caused by inadequate function of the immune system itself, i.e. by dysregulation. On the basis of examples for the latter, and outlook is finally provided of how techniques of computational simulation of such regulatory pathways can contribute to the study of immunology and tumor induction and growth.

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Authors and Affiliations

  1. Department of Pathology & Laboratory Medicine and of Internal Medicine, The University of Texas – Houston Medical School, 6431 Fannin St., Houston, Texas, 77030, USA

    Gerhard R. F. Krueger

  2. Department of Pathology and Laboratory Medicine, University of Texas – Houston Medical School, 6431 Fannin St., Houston, Texas, 77030, USA

    L. Maximilian Buja

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  1. Gerhard R. F. Krueger
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Editors and Affiliations

  1. Department of Pathology, School of Medicine, University of Maryland, Baltimore, MD, USA

    Hans E. Kaiser

  2. Department of Clinical Pathology, University of Vienna, Austria

    Hans E. Kaiser

  3. Department of Interdisciplinary Oncology-Pathology, Moffit Cancer Center & Research Institute, Tampa, FL, USA

    Aejaz Nasir

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Krueger, G.R.F., Buja, L.M. (2008). Abnormal variation of the immune response as related to cancer. In: Kaiser, H.E., Nasir, A. (eds) Selected Aspects of Cancer Progression: Metastasis, Apoptosis and Immune Response. Cancer Growth and Progression, vol 11. Springer, Dordrecht. https://doi.org/10.1007/978-1-4020-6729-7_12

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