Plants are the ultimate source of many of today’s pharmaceutical compounds, but most of our protein drugs are derived from animal sources, and are produced either in cultured animal cells or microbes. The biopharmaceutical industry has developed with mammalian cells treated as the gold standard for production, hence the regulations governing biopharmaceutical production have been tailored for these systems.biopharmaceutical production, despite their many potential advantages which include the prospect of inexpensive, large-scale biopharmaceutical production without sacrificing product quality or safety. The first plant-derived pharmaceutical products have now been approved but these represent a tiny proportion of the products in development, products which could have a profound impact on the cost and availability of medicines to those most in need. In this review, we summarize the state-of-the-art in plant-based production systems and discus the development issues which remain to be addressed before plants become an acceptable mainstream production technology.
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Fischer, R., Twyman, R.M., Hellwig, S., Drossard, J., Schillberg, S. (2007). Facing the Future with Pharmaceuticals from Plants. In: Xu, Z., Li, J., Xue, Y., Yang, W. (eds) Biotechnology and Sustainable Agriculture 2006 and Beyond. Springer, Dordrecht. https://doi.org/10.1007/978-1-4020-6635-1_2
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