Molecular diagnostic technologies will play a significant role in practice of medicine, public health and pharmaceutical industry. Together with genomics and proteomics techniques, the field of pharmacogenomics will develop, with the goal of personalization of diagnosis and therapy, for optimal efficiency and reduced toxicity, contributing to integrated healthcare. After the production of the first complete Human Genome Array at the EMBL in 2001, the array was validated in applications in several biomedical fields and the results published during the few following years. By the end of 2003 and early 2004, several well known commercial companies have announced the availability of similar comprehensive DNA arrays with oligonucleotides, short (22-70 bases long) DNA fragments. Among them Affymetrix, Agilent, Applied Biosystems. In the meantime the start-up company Nimblegen Systems offers the whole human genome on an array it sells as a service, with clients sending in the test sample mRNA, the company synthesises the oligonucleotide array designed by the customer, performs the tests and analysis, then delivers the results to the customers. Illumina company offers a bead based platform for gene expression profiling and genotyping.
Keywords: Microarray techniques, protein and antibody arrays, single cell analysis, RNA interference, cell arrays, stem cells.
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Ansorge, W.J. (2007). Microarray and Single Cell Analysis Techniques in Bio-medical Fields. In: Pifat-Mrzljak, G. (eds) Supramolecular Structure and Function 9. Springer, Dordrecht. https://doi.org/10.1007/978-1-4020-6466-1_15
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