A suite of mathematical models for epidermal wound healing is presented. The models deal with the sequential steps of angiogenesis (neovascularization) and wound contraction (the actual healing of a wound). An innovation is the combination of the two processes which do not take place in a complete sequential manner but overlap partially. The models consist of nonlinearly coupled diffusion–reaction equations, in which transport of oxygen, growth factors, and cells, and mitosis are taken into account. Further, Adam’s alternative model, which is based on the assumption of the presence of an active layer at the wound edge, is described and some implications are presented. An important feature of the model due to Adam is that the wound edge is tracked explicitly as a part of the solution. In this work several numerical methods to solve the moving boundary problem are described.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2007 Springer
About this chapter
Cite this chapter
Vermolen, F., van Rossum, M.W.G., Perez, E.J., Adam, J. (2007). Modeling of Self Healing of Skin Tissue. In: van der Zwaag, S. (eds) Self Healing Materials. Springer Series in Materials Science, vol 100. Springer, Dordrecht. https://doi.org/10.1007/978-1-4020-6250-6_16
Download citation
DOI: https://doi.org/10.1007/978-1-4020-6250-6_16
Publisher Name: Springer, Dordrecht
Print ISBN: 978-1-4020-6249-0
Online ISBN: 978-1-4020-6250-6
eBook Packages: Chemistry and Materials ScienceChemistry and Material Science (R0)