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β-Catenin, its Binding Partners and Signalling Mechanisms: Implications in Prostate Cancer

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Metastasis of Prostate Cancer

Part of the book series: Cancer Metastasis – Biology and Treatment ((CMBT,volume 10))

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Abstract

β-catenin is a cytoplasmic protein that has been well documented in recent years by a number of investigators. It is now firmly established that β-catenin plays a dual role through its function in facilitating intercellular adhesion by binding to E-cadherin, and also for its key role as a mediator of the Wnt signal transduction pathway. This chapter summarises some of the scientific and clinical advances made during the last decade on the molecular and cellular functions of β-catenin, including its role in Wnt signalling, adherence junction assembly and its impact on prostate cancer progression.

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Authors and Affiliations

  1. Metastasis Research Group, University Department of Surgery, University of Wales College of Medicine, Heath Park, Cardiff, Wales, UK

    Gaynor Davies & Gregory M. Harrison

  2. Department of Medicine, Section of Clinical Oncology, Velindre Hospital, Cardiff, Wales, UK

    Malcolm D. Mason

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  1. Gaynor Davies
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  2. Gregory M. Harrison
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  3. Malcolm D. Mason
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Editors and Affiliations

  1. University of Arizona College of Medicine, and the Arizona Cancer Center, Tucson, AZ, U.S.A

    Richard J. Ablin

  2. University of Cardiff, U.K

    Malcolm D. Mason

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Davies, G., Harrison, G.M., Mason, M.D. (2008). β-Catenin, its Binding Partners and Signalling Mechanisms: Implications in Prostate Cancer. In: Ablin, R.J., Mason, M.D. (eds) Metastasis of Prostate Cancer. Cancer Metastasis – Biology and Treatment, vol 10. Springer, Dordrecht. https://doi.org/10.1007/978-1-4020-5847-9_9

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