In Chapter 16 we introduced the proposal that membrane excitability is based on ferroelectric properties in membrane molecules. Smectic liquid crystals, we saw in Chapter 17, are capable of exhibiting ferroelectricity when chiral molecules are tilted with respect to the layer normal. Here we explore this proposal, extending it to the molecular level. We saw in Chapter 19 that, while the size of the domain is indeed a limiting factor, voltage-sensitive ion channels are large enough to be capable of sustaining a ferroelectric domain, and that electric fields and temperature variations can switch this ferroelectric phase on and off. We will explore ways in which this phase transition can alter the ion conductance of the channel.
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(2009). Voltage-Induced Gating Of Ion Channels. In: Leuchtag, H.R. (eds) Voltage-Sensitive Ion Channels. Springer, Dordrecht. https://doi.org/10.1007/978-1-4020-5525-6_20
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