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REGULATION OF CADHERINS DURING PROSTATE CANCER PROGRESSION

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Cell Adhesion and Cytoskeletal Molecules in Metastasis

Part of the book series: Cancer Metastasis – Biology and Treatment ((CMBT,volume 9))

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Abstract

Disruption of tight cell adhesion mediated by E-cadherin is an important step in carcinoma progression for cells to initiate cell migration and progress to metastasize. During prostate cacinogenesis, E-cadherin gene expression or function is downregulated through multiple mechanisms, many of which combine to silence E-cadherin expression through transcriptional regulation at the level of the E-cadherin promoter. Recent evidence indicates that concomitant with the transcriptional silencing of E-cadherin in prostate carcinomas, there is transcriptional upregulation of the mesenchymal cadherin, N-cadherin. The mechanisms of E- to N-cadherin switching in carcinomas and Key the potential roles of N-cadherin in tumor metastasis are summarized.

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Authors and Affiliations

  1. Department of Surgery and the Cancer Biology GraduateProgram, Arizona Health Sciences Center, University of Arizona, Tucson, AZ, USA

    Ronald L. Heimark & Nelson R. Alexander

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  1. Ronald L. Heimark
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  2. Nelson R. Alexander
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  1. University of Arizona, Tucson, AZ, U.S.A.

    Anne E. Cress

  2. University of Arizona, Tucson, AZ, U.S.A.

    Raymond B. Nagle

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Heimark, R.L., Alexander, N.R. (2006). REGULATION OF CADHERINS DURING PROSTATE CANCER PROGRESSION. In: Cress, A.E., Nagle, R.B. (eds) Cell Adhesion and Cytoskeletal Molecules in Metastasis. Cancer Metastasis – Biology and Treatment, vol 9. Springer, Dordrecht. https://doi.org/10.1007/978-1-4020-5129-6_3

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