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Selective Minimally Invasive Therapy in Older Patients for Localized Prostate Cancer: A Way to Mitigate Harm and Retain Benefit?

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Management of Urological Cancers in Older People

Part of the book series: Management of Cancer in Older People ((volume 1))

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Abstract

The benefits of screening and treatment of localized prostate cancer are increasingly in question. Some of this uncertainty can be attributed to the treatment-related morbidity and impact on quality of life that exists from current standard treatment options, e.g., external beam radiotherapy and radical prostatectomy. A potential strategy that offers cancer control with reduced treatment-related harm is known as “focal therapy,” which targets treatment to the tumor rather than the whole organ. This chapter explores the rationale for this new treatment concept, its application within the elderly population, and the diagnostic investigations and therapeutic technologies available to us for localization of disease and targeting of treatment. We also explore the results of recent clinical trials in this area and possible future directions in this new treatment strategy.

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Authors and Affiliations

  1. Department of Urology, University College Hospitals NHS Foundation Trust, London, UK

    Louise Dickinson M.B.B.S., B.Sc.(Hons), MRCS, Hashim Uddin Ahmed MRCS(Ed), BM, BCh (Oxon), B.A.(Hons) & Mark Emberton M.D., FRCS (Urol)

Authors
  1. Louise Dickinson M.B.B.S., B.Sc.(Hons), MRCS
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  2. Hashim Uddin Ahmed MRCS(Ed), BM, BCh (Oxon), B.A.(Hons)
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  3. Mark Emberton M.D., FRCS (Urol)
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Corresponding author

Correspondence to Louise Dickinson M.B.B.S., B.Sc.(Hons), MRCS .

Editor information

Editors and Affiliations

  1. Lyon-RTH Laënnec School of Medicine, Lyon, France

    Jean-Pierre Droz

  2. University of Liverpool, St Helens Teach, Marshalls Cross Road, St Helens, WA9 3DA, United Kingdom

    Riccardo A. Audisio

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© 2013 Springer-Verlag London

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Dickinson, L., Ahmed, H.U., Emberton, M. (2013). Selective Minimally Invasive Therapy in Older Patients for Localized Prostate Cancer: A Way to Mitigate Harm and Retain Benefit?. In: Droz, JP., Audisio, R. (eds) Management of Urological Cancers in Older People. Management of Cancer in Older People, vol 1. Springer, London. https://doi.org/10.1007/978-0-85729-999-4_10

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  • DOI: https://doi.org/10.1007/978-0-85729-999-4_10

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  • Publisher Name: Springer, London

  • Print ISBN: 978-0-85729-986-4

  • Online ISBN: 978-0-85729-999-4

  • eBook Packages: MedicineMedicine (R0)

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