Abstract
Extensive traumatic loss of functional and composite structures of the face (skin, muscles, nerves, and bones) results in significant reorganization of the primary motor (M1) and somatosensory (S1) cortex. The first near-total US face transplant offers a unique opportunity to study the relearning process of integrating cortical representations of motor and sensory functions which were lost over a 5-year period following the patient’s initial trauma. Using the functional EEG technique, we have found that trauma-induced cortical reorganization and associated loss of functions can gradually be reversed following face transplantation. The relearning of lost facial function governed by the somatosensory cortex confirms cortical plasticity and adaptation to the newly acquired functions. The restored functions in the transplant patient were found in the same areas of the motor cortex as in normal controls.
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Abbreviations
- ANOVA:
-
Analysis of Variance
- BESA:
-
Brain Electromagnetic Source Analysis
- CNS:
-
Central Nervous System
- EEG:
-
Electroencephalography
- EMG:
-
Electromyography
- ENG:
-
Electroneurography
- FFT:
-
Fast Fourier Transform
- fMRI:
-
Functional Magnetic Resonance Imaging
- IRB:
-
Institutional Review Board
- MEG:
-
Magnetic Encephalography
- MRCP:
-
Motor-Related Cortical Potentials
- M1:
-
Primary Motor Cortex
- MEP:
-
Motor-Evoked Potentials
- NP:
-
Negative Potential
- PET:
-
Positron Emission Tomography
- S1:
-
Primary Somatosensory Cortex
- SEF:
-
Somatosensory-Evoked Magnetic Fields
- SSEP:
-
Somatosensory-Evoked Potentials
- TMS:
-
Transcranial Magnetic Stimulation
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Siemionow, V. (2011). Functional EEG Assessment of Face Transplantation. In: Siemionow, M. (eds) The Know-How of Face Transplantation. Springer, London. https://doi.org/10.1007/978-0-85729-253-7_20
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DOI: https://doi.org/10.1007/978-0-85729-253-7_20
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