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Angiogenic Growth Factors

  • Chapter
Biology of the Arterial Wall

Part of the book series: Basic Science for the Cardiologist ((BASC,volume 1))

Abstract

Hitherto, formation of new blood vessels was usually classified into two well-known embryological phenomenons: vasculogenesis and angiogenesis. Vasculogenesis is described as a primary in situ differentiation of endothelial cells from mesodermal precursors, leading to the formation of primary capillary poleaxe. Angiogenesis was thought to be exclusively the result of vessels’ sprouting from pre-existing vessels. But recently, Asahara et al. have showed that circulating endothelial cell progenitors are also involved in the angiogenic process [1]. Concerning collateral vessel formation, a third concept, called “arteriogenesis” has been introduced by Schapper [2]. It consists of the remodeling of small capillaries into larger arterioles, with a muscular layer. Nevertheless, those three entities require:

  • proliferation and migration with a spatial organisation of endothelial cells

  • dissolution and regeneration of the vascular extracellular matrix, considered as vascular stake

  • participation of mesenchymal perivascular cells (smooth muscle cells and pericytes)

.

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Authors and Affiliations

  1. Faculté de médecine X, Inserm u 460 Remodelage cardiovasculaire, Bichat Paris, France

    Cedric J. Gaultier & Jean-Baptiste Michel

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  1. Cedric J. Gaultier
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  1. Lariboisiére hospital, INSERM U141, Paris, France

    Bernard I. Levy  & Alain Tedgui  & 

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Gaultier, C.J., Michel, JB. (1999). Angiogenic Growth Factors. In: Levy, B.I., Tedgui, A. (eds) Biology of the Arterial Wall. Basic Science for the Cardiologist, vol 1. Springer, Boston, MA. https://doi.org/10.1007/978-0-585-38146-6_6

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  • DOI: https://doi.org/10.1007/978-0-585-38146-6_6

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