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Neurohumoral Control of the Vascular System

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Biology of the Arterial Wall

Part of the book series: Basic Science for the Cardiologist ((BASC,volume 1))

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Abstract

Through the modification of the neuronal discharge or changes in circulating catecholamines, the autonomic nervous system induces central or local vasomotor alterations and participates in the control of the internal environment and homeostasis. The vascular smooth muscle is the effector organ for these alterations. Indeed, with the exception of capillaries and some venules, the vessels have the ability to alter their calibre, to influence the regional (or total) peripheral resistance and capacitance, and to influence the cardiac output and its distribution. Several studies have demonstrated the extreme diversity of responses of different blood vessels to alteration in autonomic control [1].

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References

  1. Bevan JA, Bevan RD. « Changes in arteries as they get smaller. » In Vasodilatation: Vascular smooth muscle, peptides, autonomic nerves and endothelium PM Vanhoutte ed. New York: Raven Press Ltd, 1988.

    Google Scholar 

  2. Bevan JA. Pressure and flow: are these the true vascular neuroeffectors? Blood Vessels 1991;28(1–3):164–172

    PubMed  CAS  Google Scholar 

  3. Burnstock G. Nervous control of smooth muscle by transmitters, cotransmitters and modulators. Experientia Basel. 1985;41:869–74.

    Article  CAS  Google Scholar 

  4. Shepherd JT, Vanhoutte PM. The human cardiovascular system. Facts and concepts. New York, Raven Press, 1979.

    Google Scholar 

  5. Chalmers J, Arnolda L, Llewellyn-Smith I, Minson J, Pilowsky P. “Central control of blood pressure”. In Textbook of Hypertension, JD Swales, ed., Blackwell Scientific Publications, 1994.

    Google Scholar 

  6. Chalmers J, Pilowsky P. Brainstem and bulbospinal neurotransmitter system in the control of blood pressure. J Hypertens 1991;9:675–694.

    Article  PubMed  CAS  Google Scholar 

  7. Angus JA, Brougton A, Mulvany MJ. Role of alpha-adrenoceptors in constrictor responses of rat, guinea-pig and rabbit small arteries to neural activation. J Physiol Lond 1988;403:495–510.

    PubMed  CAS  Google Scholar 

  8. Mulvany MJ, Aalkjaer C. Structure and function of small arteries. Physiol Rev 1990;70:921–61.

    PubMed  CAS  Google Scholar 

  9. Lundberg JM. Pharmacology of co-transmission in the autonomic nervous system: integrative aspects on amines, neuropeptides, adenosine triphosphate, aminoacids, and nitric oxide. Pharmacol Rev 1996;48:113–178.

    PubMed  CAS  Google Scholar 

  10. Gavazzi I, Boyle KS, Cowen T. Extracellular matrix molecules influence innervation density in rat cerebral blood vessels. Brain Res 1996;23:167–174.

    Article  Google Scholar 

  11. Lacolley P, Lewis S, Brody MJ. Role of sympathetic nerve activity in the generation of vascular nitric oxide in urethane anesthetised rats. Hypertension 1991;17:881–887.

    PubMed  CAS  Google Scholar 

  12. Gow BS. Circulatory correlates: vascular impedance, resistance, and capacitance. In DF Bohr et al (Eds.), The cardiovascular system, Vol II. Vascular smooth muscle (pp. 353–408). Baltimore: American Physiological Society (The Williams & Wilkins Company), 1980.

    Google Scholar 

  13. Furchgott RF, Zawadzki JV, Cherry PD. Role of endothelium in the vasodilator response to acetylcholine. In PM Vanhoutte and I Leusen (Eds.), Vasodilation (pp. 49–66). New York, Raven Press Publishers, 1981.

    Google Scholar 

  14. Pohl U, Holtz J, Buss R, Bassenge E. Crucial role of endothelium in the vasodilator response to increased flow in vivo. Hypertension 1986; 8: 37–44.

    PubMed  CAS  Google Scholar 

  15. Barnett GO, Mallos AJ, Shapiro A. Relationship of aortic pressure and diameter in the dog. J Appl Physiol 1961; 16: 545–8.

    PubMed  CAS  Google Scholar 

  16. Pagani M, Mirsky L, Baig H, Manders WY, Kerkhof P, Vatner SF. Effects of age on aortic pressure-diameter and elastic stiffness stress relationships in unanesthetized sheep. Circ Res 1979;44:420–9.

    PubMed  CAS  Google Scholar 

  17. Hughes AD, Thom SAM, Martin GN. Size and site-dependent heterogeneity of human vascular responses in vitro. J. Hypertens, 1988;6(Suppl. 4): S173–5.

    CAS  Google Scholar 

  18. Aars H. Diameter and elasticity of the ascending aorta during infusion of noradrenaline. Acta Physiol Scand 1971;83:133–138.

    Google Scholar 

  19. Cox RH. Effects of norepinephrine on mechanics of arteries in vivo. Am J Physiol 1976; 2315: 420–425.

    Google Scholar 

  20. Laher I, Bevan JA. Alpha-adrenoreceptor number limits response of some rabbit arteries to norepinephrine. J Pharmacol Exp Ther 1985;233: 290–297.

    PubMed  CAS  Google Scholar 

  21. Owen MP, Quinti CA, Bevan JA. Phentolamine-resistant neurogenic constriction occurs in small arteries at higher frequencies. Am J Physiol 1985; 249(Heart Circ. Physiol., 18): H404–14.

    PubMed  CAS  Google Scholar 

  22. McDonald DA. Bloodflow in arteries. London: Edward Arnold, 1974.

    Google Scholar 

  23. Peterson LH, Jensen RE, Pamell R. Mechanical properties of arteries in vivo. Circ Res, 1960; 8:622–39.

    Google Scholar 

  24. Bagshaw RJ, Peterson LH. Sympathetic control of the mechanical properties of the canine carotid sinus. Am J Physiol 1972; 222: 1462–8.

    PubMed  CAS  Google Scholar 

  25. Dobrin PB, Rovick AA. Influence of vascular smooth muscle on contractile mechanics and elasticity of arteries. Am J Physiol 1969; 217: 1644–51.

    PubMed  CAS  Google Scholar 

  26. Gow BS. The influence of vascular smooth muscle on the visco-elastic properties of blood vessels. In Cardiovascular fluid dynamics, DH Bergel, ed. New York, Academic Press, 1972.

    Google Scholar 

  27. Boutouyrie P, Lacolley P, Girerd X., Beck L., Safar M., Laurent S. Sympathetic activation decreases radial artery compliance in humans. Am J Physiol 1994;267:H1368–76.

    PubMed  CAS  Google Scholar 

  28. Joannides R, Richard V, Moore N, Godin M, Thuillez C. Influence of sympathetic tone on mechanical properties of muscular arteries in humans. Am J Physiol 1995 Feb;268(2 Pt2):H794–H801.

    Google Scholar 

  29. Prichard BNC, Weber MA. “Antiadrenergic drugs. Principles and practice of a-antiadrenergic therapy”. In Cardiovascular Drug Therapy, Franz Messerli ed. Philadelphia, Saunders Publishing 1996.

    Google Scholar 

  30. Timmermans PMBWM, Van Zwieten PA. “Alpha-adrenoreceptors antagonists”. In Pharmacology of antihypertensive drugs. Handbook of hypertension. Peter A VanZwieten, ed., Amsterdam, Elsevier Science Publishers, 1984.

    Google Scholar 

  31. Frishman WH, Hershman D. “Beta-adrenoreceptor blockers. Principles and practice of beta-adrenoreceptor blockade.”. In Cardiovascular Drug Therapy, Franz Messerli ed. Philadelphia, Saunders Publishing 1996.

    Google Scholar 

  32. Kiowski W, Hulthen UL, Ritz R, Buhler FR. Alpha 2-adrenoreceptor mediated vasoconstriction in human arterial vessels. Clin Pharmacol Ther 1983; 34: 565–9.

    Article  PubMed  CAS  Google Scholar 

  33. Jie K, Van Brummelen P, Vermey P, Timmermans PBMWM, Van Zwieten PA Effects of exogenous adrenaline and noradrenaline on vascular post-synaptic alpha1 and alpha2 adrenoreceptors in man. J Hypertens 1984, 2(Suppl 3): 119–21.

    CAS  Google Scholar 

  34. Safar M, Peronneau J, Levenson J, Simon A. Pulsed Doppler: diameter velocity and flow of brachial artery in sustained essential hypertension. Circulation 1981; 63: 393–400.

    PubMed  CAS  Google Scholar 

  35. Laurent S, Juillerat L, London GM, Nussberger J, Brunner H, Safar ME. Increased response of brachial artery diameter to norepinephrine in hypertensive patients. Am J Physiol 1988; 255: H36–43.

    PubMed  CAS  Google Scholar 

  36. Laurent S, Iacolley P, Brunel P, Safar M. Effects of short lasting mental stress on systemic and brachial haemodynamics in essential hypertension. Circulation 1988; 78(Suppl. IV): IV–175.

    Google Scholar 

  37. Safar ME, Daou JE, Safavian A, London GM. Comparison of forearm plethysmographic methods with brachial artery Doppler flowmetry in man. Clin Physiol 1988; 8:163–70.

    PubMed  CAS  Google Scholar 

  38. Anderson EA, Sinkey CA, Mark AL. Mental stress increases sympathetic nerve activity during sustained baroreceptor stimulation in humans. Hypertension 1991 Apr;17(4 Suppl):III43–III49

    Google Scholar 

  39. Stauss HM, Anderson EA, Haynes WG, Kregel KC. Frequency response characteristics of sympathetically mediated vasomotor waves in humans. Am J Physiol. 1998 Apr; 274(4 Pt 2): H1277–H1283.

    Google Scholar 

  40. Shepherd JT, Abboud FM. Peripheral circulation and organ blood flow. The Cardiovascular System.. Handbook of Physiology. Bethesda, Maryland, 1983.

    Google Scholar 

  41. Man’in’t Veld AJ, Shalekamp MADH. Effects of 10 different beta-adrenoreceptors antagonists in hemodynamics, plasma renin activity and plasma norepinephrine in hypertension. The key role of vascular resistance changes in relation to partial agonist activity. J Cardiovasc Pharmacol 5(suppl 1): S30–S36, 1983.

    Article  Google Scholar 

  42. Gerova M, Gero J, Dolezel S, Blazkova-Huzulakova I. Sympathetic control of canine abdominal aorta. Circ Res 1973;33:149–152.

    PubMed  CAS  Google Scholar 

  43. Aars H. Effects of altered smooth muscle tone on aortic diameter and aortic baroreceptor activity in anesthetised rabbits. Circ Res 1971;28:254–62.

    PubMed  CAS  Google Scholar 

  44. Cox RH. Mechanics of canine iliac artery smooth muscle in vitro. Am J Physiol 1976;230:462–70.

    PubMed  CAS  Google Scholar 

  45. Laurent S, Lacolley P, Brunel P, Laloux B, Pannier B, Safar M. Flow-dependent vasodilation of the brachial artery in essential hypertension. Am J Physiol 1990, 258(Heart Circ. Physiol. 27): H1004–H1011.

    PubMed  CAS  Google Scholar 

  46. London GM, Pannier BP, Laurent S, Safar ME. Cardiopulmonary baroreflex control of brachial artery diameter in sustained essential hypertension. J Hypertens 1989; 7 879–83.

    Article  PubMed  CAS  Google Scholar 

  47. Anderson EA, Mark AL. Flow-mediated and reflex changes in large peripheral artery tone in humans. Circulation 1989; 79: 93–100.

    PubMed  CAS  Google Scholar 

  48. Tardy Y, Meister J-J, Perret F, Brunner H, Ardity M. Non-invasive estimate of the mechanical properties of peripheral arteries from ultrasonic and photoplethysmographic measurements. Clin Phys Physiol Meas 1991:12;39–54.

    Article  PubMed  CAS  Google Scholar 

  49. Hoeks APG, Brands PJ, Smeets GAM, Reneman RS. Assessment of the distensibility of superficial arteries. Ultrasound Med Biol 1990; 16: 121–128.

    Article  PubMed  CAS  Google Scholar 

  50. Kelly R, Daley J, Avollo A, O’Rourke MF. Arterial dilation and reduced wave reflection. Benefit of dilevalol in hypertension. Hypertension 1989; 14:14–21.

    PubMed  CAS  Google Scholar 

  51. Laurent S, Caviezel B, Beck L, Girerd X, Billaud E, Boutouyrie P, Hoeks A, Safar M. Carotid artery distensibility and distending pressure in hypertensive humans. Hypertension 1994;23[part 2]:878–883.

    PubMed  CAS  Google Scholar 

  52. Levenson J, Simon ACh, Bouthier JD, Benetos A, Safar ME. Post-synaptic alpha-blockade and brachial artery compliance in essential hypertension. J Hypertens 1984;2: 37–41.

    Article  PubMed  CAS  Google Scholar 

  53. London GM, Laurent S, Safar M. “The autonomic nervous system and large conduit arteries”. In Vasodilation, M O’Rourke, M Safar, V Dzau, Eds, London, Edward Arnold, 1993.

    Google Scholar 

  54. Madkour A, Levenson J, Bravo El„ Simon A & Fouad-Tarazi FM (1989) Preload, adrenergic activity, and aortic compliance in normal and hypertensive patients. Am. Heart. J. 1183 1243–7.

    Article  Google Scholar 

  55. London GM, Levenson JA, Safar ME, Simon AC, Guerin AP, Payen D. Hemodynamic effects of head-down tilt in normal subjects and sustained hypertensive patients. Am J Physiol 1983; 245:H194–H202.

    PubMed  CAS  Google Scholar 

  56. Roddie IC, Shepherd JT, Whelan RF. Reflex changes in vasoconstrictor tone in human skeletal muscle in response to stimulation of receptors in low-pressure area of the intrathoracic vascular bed. J Physiol (Lond) 1957; 139: 369–76.

    CAS  Google Scholar 

  57. Simon ACh, Levenson JA, Bouthier JA, Safar ME. Comparison of MK 421 and propranolol in mild to moderate essential hypertension and their effects on arterial and venous vessels of the forearm. Am J Cardiol 1984; 53:781–5.

    Article  PubMed  CAS  Google Scholar 

  58. Levenson JA, Simon ACh, Fiessinger JN, Safar ME, London GM, Housset EM (1982) Systemic arterial compliance in patients with arteriosclerosis obliterans of the lower limbs. Observation on the effect of intravenous propranolol. Arteriosclerosis, 2, 266–71.

    PubMed  CAS  Google Scholar 

  59. Maarek BL, Bouthier JA, Simon ACh, Levenson J, Safar ME. Comparative effects of propranolol and pindolol on small and large arteries and veins of the forearm circulation in hypertensive man. J Cardiovasc Pharmacol 1986; 8:(Suppl 4) S61–6.

    Article  PubMed  Google Scholar 

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© 1999 Kluwer Academic Publishers

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Laurent, S. (1999). Neurohumoral Control of the Vascular System. In: Levy, B.I., Tedgui, A. (eds) Biology of the Arterial Wall. Basic Science for the Cardiologist, vol 1. Springer, Boston, MA. https://doi.org/10.1007/978-0-585-38146-6_3

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  • DOI: https://doi.org/10.1007/978-0-585-38146-6_3

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-0-7923-8458-8

  • Online ISBN: 978-0-585-38146-6

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