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Arterial Gene Transfer

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Biology of the Arterial Wall

Part of the book series: Basic Science for the Cardiologist ((BASC,volume 1))

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Abstract

Atherosclerosis and its complications represent the first cause of mortality and morbidity in the western world. Major advances have been made in the treatment and prevention of symptomatic atherosclerosis. Improved understanding of the pathophysiology of atherosclerosis and its complications [1], as well as spectacular advances in the molecular biology of the vascular wall [2] may open new perspectives for treatment based upon local delivery of genetic material designed to modify the atherosclerotic plaque at the molecular level [3]. Transfer of a functional gene into arterial wall cells, termed arterial gene therapy, may be used to replace or palliate a defective gene, or to express a protein with a therapeutic effect [4].

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Authors and Affiliations

  1. Cardiology Department and U460 INSERM, Faculté Xavier Bichat, Paris, France

    Laurent J. Feldman & Ph. Gabriel Steg

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  1. Laurent J. Feldman
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  1. Lariboisiére hospital, INSERM U141, Paris, France

    Bernard I. Levy  & Alain Tedgui  & 

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© 1999 Kluwer Academic Publishers

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Feldman, L.J., Steg, P.G. (1999). Arterial Gene Transfer. In: Levy, B.I., Tedgui, A. (eds) Biology of the Arterial Wall. Basic Science for the Cardiologist, vol 1. Springer, Boston, MA. https://doi.org/10.1007/978-0-585-38146-6_13

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  • DOI: https://doi.org/10.1007/978-0-585-38146-6_13

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-0-7923-8458-8

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