Abstract
We are studying a large autosomal dominant family with a broad clinical spectum of macular degeneration. By analyzing microsatellite markers on chromosome 6, significant positive lod sores were obtained (D6S455: Z = 4.49 at theta = 0). Linkage analysis localizes the disease-causing gene to a 22cM interval on chromosome 6q11–13 and excludes the loci for North Carolina Macular Dystrophy and Progressive Bifocal Chorioretinal Atrophy. Three other retinalJ.macular dystrophies map to overlapping intervals and could be allelic forms of the same gene or from a cluster of genes causing retinal/macular degeneration.
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© 1999 Kluwer Academic / Plenum Publishers
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Griesinger, I.B., Sieving, P.A., Ayyagari, R. (1999). Autosomal Dominant Macular Degeneration Localized to Chromosome 6q by Linkage Analysis. In: Hollyfield, J.G., Anderson, R.E., LaVail, M.M. (eds) Retinal Degenerative Diseases and Experimental Therapy. Springer, Boston, MA. https://doi.org/10.1007/978-0-585-33172-0_17
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DOI: https://doi.org/10.1007/978-0-585-33172-0_17
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