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Principles of Cancer Genetic Counseling and Genetic Testing

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Principles of Clinical Cancer Genetics

Abstract

Although only 5–10% of all cases of cancer are attributable to a highly penetrant cancer predisposition gene, the identification of individuals at inherited risk for cancer has become an integral part of the practice of predictive and preventative medicine. Identifying those individuals with a significantly higher risk of developing specific cancers allows health-care providers to intervene with appropriate counseling and education, increased cancer surveillance, and sometimes even cancer prevention. This chapter focuses on the identification of patients at high risk for cancer and the importance of referral to genetic counselors and other genetics professionals. The chapter also discusses the intricacies surrounding genetic testing, including the ethical, legal, and social implications of identifying those at increased risk for cancer.

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Authors and Affiliations

  1. Center for Cancer Risk Assessment, Massachusetts General Hospital, Boston, MA, USA

    Kristen M. Shannon

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  1. Kristen M. Shannon
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  2. Devanshi Patel
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Correspondence to Kristen M. Shannon .

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Editors and Affiliations

  1. Cancer Center and Gastrointestinal Unit, Harvard Medical School, Massachusetts General Hospital, Boston, 02114, USA

    Daniel C. Chung

  2. Cancer Center, Harvard Medical School and, Massachusetts General Hospital, Boston, 02114, USA

    Daniel A. Haber

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Shannon, K.M., Patel, D. (2010). Principles of Cancer Genetic Counseling and Genetic Testing. In: Chung, D., Haber, D. (eds) Principles of Clinical Cancer Genetics. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-93846-2_2

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