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Malignancy of the Bone: Primary Tumors, Lymphoma, and Skeletal Metastases

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Hybrid PET/CT and SPECT/CT Imaging

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Abstract

Most malignant skeletal lesions initiate intramedullary. As the intramedullary malignant deposit enlarges, the surrounding bone undergoes osteoclastic and osteoblastic activity. Tumor cells may destroy bone directly or produce mediators that stimulate reabsorption by osteoclasts.1Based on the balance between the two processes, the radiographic appearance of a malignant skeletal lesion may be lytic, blastic, or mixed.2Detection of malignant skeletal involvement is based on either direct visualization of tumor cells or of the secondary reaction of the bone to the present malignant cells.

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Author information

Authors and Affiliations

  1. Department of Nuclear Medicine, Tel-Aviv Sourasky Medical Center, Tel Aviv University, Tel Aviv, Israel

    Einat Even-Sapir MD, PhD

  2. Department of Radiology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel

    Gideon Flusser MD

  3. Department of Radiology, Sackler School of Medicine, Tel Aviv Sourasky Medical Center, Tel Aviv University, Tel Aviv, Israel

    Arye Blachar MD

Authors
  1. Einat Even-Sapir MD, PhD
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  2. Gideon Flusser MD
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  3. Arye Blachar MD
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Corresponding author

Correspondence to Einat Even-Sapir MD, PhD .

Editor information

Editors and Affiliations

  1. Medical Center, Vanderbilt University, 21st Ave. S. & Garland 1161, Nashville, 37232-2675, U.S.A.

    Dominique Delbeke

  2. Dept. Nuclear Medicine, Rambam Medical Centre, Bat-Galim, Haifa, 35 254, Israel

    Ora Israel

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Even-Sapir, E., Flusser, G., Blachar, A. (2010). Malignancy of the Bone: Primary Tumors, Lymphoma, and Skeletal Metastases. In: Delbeke, D., Israel, O. (eds) Hybrid PET/CT and SPECT/CT Imaging. Springer, New York, NY. https://doi.org/10.1007/978-0-387-92820-3_16

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  • DOI: https://doi.org/10.1007/978-0-387-92820-3_16

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  • Online ISBN: 978-0-387-92820-3

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