Abstract
As the incidence of nonmelanoma skin cancer (NMSC) continues to rise, topical therapies will be used with increasing frequency. Topical therapies are currently being utilized as primary or adjunctive means of treating an array of NMSCs. Although surgical therapies, such as Mohs Micrographic Surgery (MMS), remain the mainstay for tumor removal, topical therapy provides an alternative treatment modality for some skin cancer patients as well as serving as a useful adjunct to surgery. Topical therapies may also increase overall efficacy by treating subclinical lesions and identifying asymmetrical growth of NMSCs. In some patients, such as high-risk surgical candidates, they can be used to avoid surgery altogether or to minimize the extent of surgery. Topical therapies may also be helpful in a diagnostic manner. In instances where biopsy sites are equivocal, topical therapies may facilitate tumor identification prior to surgery.
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References
Stanley MA. Imiquimod and the imidazoquinolones: mechanism of action and therapeutic potential. Clin Exp Dermatol. 2002 Oct;27(7):571–577.
Schon MP, Schon M. TLR7 and TLR8 as targets in cancer therapy. Oncogene. 2008 Jan;27(2):190–199.
Barnetson RC, Satchell A, Zhuang L, et al. Imiquimod induced regression of clinically diagnosed superficial basal cell carcinoma is associated with early infiltration by CD4 T cells and dendritic cells. Clin Exp Dermatol. 2007 Feb;29:639–643.
Wolf IH, Kodama K, Cerroni L, et al. Nature of inflammatory infiltrate in superficial cutaneous malignancies during topical imiquimod treatment. Am J Dermatopathol. 2007 Jun;29(3):237–241.
Stary G, Bangert C, Tauber M, et al. Tumoricidal activity of TLR7/8-activated inflammatory dendritic cells. J Exp Med. 2007 Jun;204(6):1441–1451.
Urosevic M, Dummer R, Conrad C, et al. Disease-independent skin recruitment and activation of plasmacytoid predendritic cells following imiquimod treatment. J Nat Can Inst. 2005 Aug;97(15):1143–1153.
Quatresooz P, Pierard GE. Imiquimod-responsive basal cell carcinomas and factor XIIIa-enriched dendrocytes. Clin and Exp Derm. 2003 Aug;28(Suppl 1):27–29.
Gaspari AA, Sauder D. Immunotherapy of basal cell carcinoma: evolving approaches. Dermatol Surg. 2003;29:1027–1034. Review PMID: 12974699, Wiley-Blackwell.
Torres A, Storey L, Anders M, et al. Microarray analysis of aberrant gene expression in actinic keratosis: effect of the Toll-like receptor-7 agonist imiquimod. Br J Dermatol. 2007;157:1132–1147.
Metcalf SA, Crowson N, Naylor M, et al. Imiquimod as an antiaging agent. JAAD. 2007 Mar;56(3):422–425.
Smith K, Hamza S, Germain M, et al. Does imiquimod histologically rejuvenate ultraviolet radiation-damaged skin? Derm Surg. 2007;33:1419–1429.
Wolverton SE. Comprehensive Dermatologic Drug Therapy. 1st ed. Philadelphia: Saunders Elsevier; 2001:529–530.
Schon MP, Schon M. The small antitumoral immune response modifier imiquimod interacts with adenosine receptor signaling in a TLR7- and TLR8-independent fashion. J Invest Dermatol. 2006 Jun;126(6):1338–1347.
Schon MP, Schon M. Immune modulation and apoptosis induction: two sides of the antitumoral activity of imiquimod. Apoptosis. 2004 May;9(3):291–298.
Brouty-Boye D, Zetter BR. Inhibition of cell motility by interferon. Science. 1980;208:516–518.
Yoshida A, Anand-Apte B, Zetter BR. Differential endothelial migration and proliferation to basic fibroblast growth factor and vascular endothelial growth factor. Growth Factors. 1996;13:57–64.
Shousong C, Kun L, Toth K, et al. Persistent induction of apoptosis and suppression of mitosis as the basis for curative therapy with S-1, and oral 5-fluorouracil prodrug in a colorectal tumor model. Clin Cancer Res. 1999;5:267–274.
Fujita M, Kuwano K, Kunitake R, et al. Endothelial cell apoptosis in lipopolysaccharide-induced lung injury in mice. Int Arch Allergy Immunol. 1998;117:202–208.
Riedel F, Gotte K, Bergler W, et al. Expression of basic fibroblast growth factor protein and its down-regulation by interferons in head and neck cancer. Head Neck. 2000;22:183–189.
Reddy KB, Hocevar BA, Howe PH. Inhibition of G1 phase cyclin dependent kinases by transforming growth factor beta 1. J Cell Biochem. 1994;56:418–425.
Majewski S, Marczak M, Mlymarczyk B, et al. Imiquimod is a strong inhibitor of tumor cell-induced angiogenesis. Int J Dermatol. 2005;44:14–19.
Li VW, Li WW. Antiangiogenesis in the treatment of skin cancer. J Drugs Dermatol. 2008;7(Suppl 1):17–24.
Sidky Y, Borden E, Weeks C, et al. Inhibition of murine tumour growth by an interferon inducing imidazoquinolinamine. Cancer Res. 1992;52:3528–3533.
Medonca CO, Yates VM. Permanent facial hypopigmentation following treatment with imiquimod cream. Clin Exp Dermatol. 2006;31:721.
Al-Dujaili Z, Hsu S. Imiquimod-induced vitiligo. Dermatol Online J. 2007 May 1;13(2):10.
Brown T, Zirvi M, Cotsarelis G, et al. Vitiligo-like hypopigmentation associated with imiquimod treatment of genital warts. J Acad Dermatol. 2005;52(4):715–716.
Senel E, Seckin D. Imiquimod-induced vitiligo-like depigmentation. Indian J Dermatol Venereol Leprol. 2007 Nov–Dec;73(6):423.
Stefanki C, Nicolaidu E, Hadjivassilou M, et al. Imiquimod-induced vitiligo in a patient with genital warts. J Eur Acad Dermatol Venerol. 2006 Jul;20(6):755–756.
Campagne G, Roca M, Martinez A. Successful treatment of a high-grade intraepithelial neoplasia with imiquimod, with vulvar pemphigus as a side effect. Eur J Obst Gynecol Reprod Bio. 2003;109:224–227.
Chakrabarty AK, Mraz S, Geisse JK, et al. Aphthous ulcers associated with imiquimod and the treatment of actinic cheilitis. JAAD. 2005 Feb;52(2 Suppl 1):35–37.
Lin R, Ladd DJ Jr, Powell DJ, et al. Localized pemphigus foliaceus induced by topical imiquimod treatment. Arch Dermatol. 2004 Jul;140(7):889–890.
Mashiah J, Brenner S. Possible mechanisms in the induction of pemphigus foliaceus by topical imiquimod treatment. Arch Dermatol. 2005 Jul;141(7):908–909.
Marty CL, Randle HW, Walsh JS. Eruptive epidermoid cysts resulting from treatment with imiquimod. Dermatol Surg. 2005 Jul;31(7 Pt 1):780–782; discussion 782–783.
McQuillan O, Higgins SP. Acute urinary retention following self-treatment of genital warts with imiquimod 5% cream. Sex Transm Infect. 2004 Oct;80(5):419–420.
Fanti PA, Dika E, Vaccari S, et al. Generalized psoriasis induced by topical treatment of actinic keratosis with imiquimod. Int J Dermatol. 2006 Dec;45(12):1464–1465.
Gilliet M, Conrad C, Geiges M, et al. Psoriasis triggered by toll-like receptor 7 agonist imiquimod in the presence of dermal plasmacytoid dendritic cell precursors. Arch Dermatol. 2004 Dec;140(12):1490–1495.
Rajan N, Langtry JA. Generalized exacerbation of psoriasis associated with imiquimod cream treatment of superficial basal cell carcinomas. Clin Exp Dermatol. 2006 Jan;31(1):140–141.
Benson E. Imiquimod: potential risk of an immunostimulant. Australas J Dermatol. 2004 May;45(2):123–124.
Taylor CL, Maslen M, Kapembwa M. A case of severe eczema following use of imiquimod 5% cream. Sex Transm Infect. 2006 Jun;82(3):227–228.
Hanger C, Dalrymple J, Hepburn D. Systemic side effects from topical imiquimod. NZ Med J. 2005 Oct;118(1223):1–4.
De Berker D, Marren P, Powell SM, et al. Contact sensitivity to the stearyl alcohol in Efudix® cream (5-fluorouracil). Contact Dermatitis. 1992;26:138.
Farrar CW, Bell HK, King CM. Allergic contact dermatitis from propylene glycol in Efudix®. Contact Dermatitis. 2003;48:345.
Goette DK, Odom RB. Allergic contact dermatitis to topical fluorouracil. Arch Dermatol. 1977;113:1058–1061.
Meijer BUGA, de Waard-van der Spek FB. Allergic contact dermatitis because of topical use of 5-fluorouracil (Efudix® cream). Contact Dermatitis. 2007;57:58–60.
Tennstedt D, Lachapelle JM. Allergic contact dermatitis to 5-fluorouracil. Contact Dermatitis. 1987;35:124–125.
Yesudian PD, King CM. Allergic contact dermatitis from stearyl alcohol in Efudix® cream. Contact Dermatitis. 2001;45:313–314.
Harris BE, Carpenter JT, Diasio RB. Severe 5-fluorouracil toxicity secondary to dihydropyrimidine dehydrogenase deficiency. Cancer. 1991;68(3):499–501.
Johnson MR, Hageboutros A, Wang K, et al. Life threatening toxicity in a dihydropyrimidine dehydrogenase-deficient patient after treatment with topical 5-fluorouracil. Clin Cancer Res. 1999;5:2006–2011.
Takimoto CH, Lu Z-H, Zhang R, et al. Severe neurotoxicity following 5-fluorouracil-based chemotherapy in a patient with dihydropyrimidine dehydrogenase deficiency. Clin Cancer Res. 1996;2:477–481.
Tuchman M, Stoeckeler JS, Kiang DT, et al. Familial pyrimidinemia and pyrimidinuria associated with severe fluorouracil toxicity. N Engl J Med. 1985;313(4):245–249.
“Efudix®”. In: “Dictionnaire Vidal” OVP Editions du Vidal, Paris, Thérapeutique dermatologique, Médecine-Sciences Flammarion, 2001:694.
Guidance for Industry, Investigators, and Reviewers Exploratory IND Studies U.S. Department of Health and Human Services. Food and Drug Administration. Center for Drug Evaluation and Research (CDER). http://www.fda.gov/cder/guidance/index.htm. Accessed Jan 9, 2009.
Fecker LF, Stockfleth E, Nindl I, et al. The role of apoptosis in therapy and prophylaxis of epithelial tumours by nonsteroidal anti-inflammatory drugs (NSAIDS). Br J Dermatol. 2007 May;156(Suppl 3):25–33.
Kerr OA, Kavanagh G, Horn H. Allergic contact dermatitis from topical diclofenac in Solaraze gel. Contact Dermatitis. 2002 Sep;47(3):175.
Kleyn CE, Bharati A, King CM.Contact dermatitis from 3 different allergens in Solaraze® gel. Contact Dermatitis. 2004;51(4):215–216.
Valsecchi R, Pansera B, Leghissa P, et al. Allergic contact dermatitis of the eyelids and conjunctivitis from diclofenac. Contact Dermatitis. 1996 Feb;34(2):150–151.
Kowalzick L, Ziegler H. Photoallergic contact dermatitis from topical diclofenac in Solaraze gel. Contact Dermatitis. 2006 Jun;54(6)348–349.
Ridky TW. Nonmelanoma skin cancer. J Am Acad Dermatol. 2007 Sep;57(3):484–502.
Alomar A, Bichel J, McRae S. Vehicle-controlled, randomized, double-blind study to assess safety and efficacy of imiquimod 5% cream applied once daily 3 days per week in one or two courses of treatment of actinic keratoses on the head. Br J Dermatol. 2007;157:133–141.
Jorizzo J, Dinehart S, Matheson R, et al. Vehicle controlled, double blind, randomized study of imiquimod 5% cream applied 3 days per week in one or two courses of treatment for actinic keratoses on the head. J Am Acad Dermatol. 2007 Aug;57(2):265–268.
Hadley G, Derry S, Moore R. Imiquimod for actinic keratosis: systematic review and meta-analysis. J Invest Dermatol. 2006;126:1251–1255.
Korman N, Moy R, Ling M, et al. Dosing with 5% imiquimod cream 3 times per week for the treatment of actinic keratosis. Arch Dermatol. 2005 Apr;141:467–473.
Lebwohl M, Dinehart S, Whiting D, et al. Imiquimod 5% cream for the treatment of actinic keratosis: results from two phase III, randomized, double-blind, parallel group, vehicle-controlled trials. J Am Acad Dermatol. 2004 May;50(5):714–721.
Persuad AN, Shamuelova E, Sherer D, et al. Clinical effect of imiquimod 5% cream in the treatment of actinic keratosis. JAAD. 2002 Oct;47(4):553–556.
Salasche SJ, Levine N, Morrison L. Cycle therapy of actinic keratoses of the face and scalp with 5% topical imiquimod cream: an open-label trial. J Am Acad Dermatol. 2002 Oct;47(4):571–577.
Stockfleth E, Meyer T, Benninghoff B, et al. A randomized, double blind, vehicle-controlled study to assess 5% imiquimod cream for the treatment of multiple actinic keratoses. Arch Dermatol. 2002 Nov;138:1498–1502.
Szeimes R, Gerritsen MJ, Gupta G, et al. Imiquimod 5% cream for the treatment of actinic keratosis: results from a phase III, randomized, double-blind, vehicle-controlled, clinical trial with histology. J Am Acad Dermatol. 2004 Oct;51(4):547–555.
Gupta AK, Weiss JS, Jorizzo JL. 5-fluorouracil 0.5% cream for multiple actinic or solar keratoses of the face and anterior scalp. Skin Therapy Lett. 2001 Jun;6(9):1–4.
Jury CS, Ramraka-Jones VS, Gudi V, et al. A randomized trial of topical 5% 5-fluorouracil (Efudix cream) in the treatment of actinic keratoses comparing daily with weekly treatment. Br J Dermatol. 2005 Oct;153(4):808–810.
Loven K, Stein L, Furst K, et al. Evaluation of the efficacy and tolerability of 0.5% fluorouracil cream and 5% fluorouracil cream applied to each side of the face in patients with actinic keratosis. Clin Ther. 2002 Jun;24(6):990–1000.
Robbins, P. Pulse therapy with 5-FU in eradicating actinic keratoses with less than recommended dosage. J Drugs Dermatol. 2002;1:25–30.
Simmonds WL. Double-blind investigation comparing a 1% vs 5% 5-fluorouracil topical cream in patients with multiple actinic keratoses. Cutis. 1973;12:615–617.
Weiss J, Menter A, Hevia O, et al. Effective treatment of actinic keratosis with 0.5% fluorouracil cream for 1,2, or 4 weeks. Cutis. 2002 Aug;70(Suppl 2):22–29.
Fariba I, Ali A, Hossein SA, et al. Efficacy of 3% diclofenac gel for the treatment of actinic keratoses: a randomized, double-blind, placebo controlled study. Indian J Dermatol Venerol Leprol. 2006 Sep–Oct;72(5):346–349.
Gebauer K, Brown P, Varigos G. Topical diclofenac in hyaluron gel for the treatment of solar keratoses. Australas J Dermatol. 2003 Feb;44(1):40–43.
Nelson C, Rigel D, Smith S, et al. Phase IV, open-label assessment of the treatment of actinic keratosis with 3.0% diclofenac sodium topical gel (Solaraze). J Drugs Dermatol. 2004 Jul–Aug;3(4):401–407.
Pirard D, Vereecken P, Melot C, et al. Three percent diclofenac in 2.5% hyaluron gel in the treatment of actinic keratoses: a meta-analysis of the recent studies. Arch Dermatol Res. 2005 Nov;297(5):185–189.
Rivers JK, Arlette J, Shear N, et al. Topical treatment of actinic keratoses with 3.0% diclofenac in 2.5% hyaluronan gel. Br J Dermatol. 2002 Jan;146(1):94–100.
Krawthcenko N, Roewert-Huber J, Ulrich M, et al. A randomized study of topical 5% imiquimod vs. topical 5-fluorouracil vs cryosurgery in immunocompetent patients with actinic keratoses: a comparison of clinical and histological outcomes including 1 year follow up. Br J Dermatol. 2007;157 (Suppl 2):34–40.
Tanghetti E, Werschler WP. Comparison of 5% 5-fluorouracil cream and 5% imiquimod cream in the management of actinic keratoses on the face and scalp. J. Drugs Dermatol. 2007 Feb;6(2):144–147.
Gupta AK, Davey V, Mcphail H. Evaluation of the effectiveness of imiquimod and 5-fluorouracil for the treatment of actinic keratosis: critical review and meta-analysis of efficacy studies. J Cutan Med Surg. 2005 Oct;9(5):209–214.
Price NM. The treatment of actinic keratoses with a combination of 5-fluorouracil and imiquimod creams. J Drugs Dermatol. 2007 Aug;6(8):778–781.
Jorizzo J, Weiss J, Furst K, et al. Effect of a 1-week treatment with 0.5% topical fluorouracil on occurrence of actinic keratosis after cryosurgery: a randomized, vehicle-controlled clinical trial. Arch Dermatol. 2004 Jul;140(7):813–816.
Jorizzo J, Weiss J, Vamvakias G. One-week treatment with 0.5% fluorouracil cream prior to cryosurgery in patients with actinic keratoses: a double blind, vehicle-controlled, long-term study. J Drugs Dermatol. 2006 Feb;5(2):133–139.
Berlin J, Rigel D. A prospective double-arm, multicenter, open-label phase IV evaluation of the use of diclofenac sodium 3% gel in the treatment of AK lesions post-cryosurgery. J Am Acad Dermatol. 2007 Jan P2303 poster presentation.
Gold MH. Pharmacoeconomic analysis of the treatment of multiple actinic keratoses. J Drugs Dermatol. 2008 Jan;7(1):23–25.
Kircik L, Earl M. Pharmacoeconomic evaluation of 5-fluorouracil for the treatment of actinic keratosis. J Am Acad Dermatol. 2007 Jan P2301 poster presentation
“Imiquimod” www.drugs.com, last updated December 11, 2008.
Beutner KR, Geisse JK, Helman D, et al. Therapeutic response of basal cell carcinoma to the immune response modifier imiquimod 5% cream. J Am Acad Dermatol. 1999 Dec;41(6):1002–1007.
Eigentler TK, Kamin A, Weide BM, et al. A phase III, randomized, open label study to evaluate the safety and efficacy of imiquimod 5% cream applied thrice weekly for 8 and 12 weeks in the treatment of low-risk nodular basal cell carcinoma. J Am Acad Dermatol. 2007 Oct;57(4):616–621.
Ezughah FI, Dawe RS, Ibbotson SH, et al A randomized parallel study to assess the safety and efficacy of two different dosing regimens of 5% imiquimod in the treatment of superficial basal cell carcinoma. J Dermatolg Treat. 2008;19(2):111–117.
Geisse J, Caro I, Lindholm J, et al. Imiquimod 5% cream for the treatment of superficial basal cell carcinoma: results from two phase III, randomized, vehicle-controlled studies. J Am Acad Dermatol. 2004 May;50(5):722–733.
Huber A, Huber JD, Skinner RB, et al. Topical imiquimod treatment for nodular basal cell carcinomas: an open label series. Dermatol Surg. 2004;30:429–430.
Marks R, Gebauer K, Shumack S, et al. Imiquimod 5% cream in the treatment of superficial basal cell carcinoma: results of a multicenter 6-week dose-response trial. J Am Acad Dermatol. 2001 May;44(5):807–813.
Schiessl C, Wolber C, Tauber M, et al. Treatment of all basal cell carcinoma variants including large and high-risk lesions with 5% imiquimod cream: histological and clinical changes, outcome, and follow-up. J Drugs Dermatol. 2007 May;6(5):507–513.
Schulze HJ, Cribler B, Requena L, et al. Imiquimod 5% cream for the treatment of superficial basal cell carcinoma: results from a randomized vehicle-controlled phase III study in Europe. Br J Dermatol. 2005 May;152(5):939–947.
Shumack S, Robinson J, Kossard S, et al. Efficacy of topical 5% imiquimod cream for the treatment of nodular basal cell carcinoma. Arch Dermatol. 2002 Sep;138:1165–1171.
Torres A, Niemeyer A, Berkes B, et al. 5% imiquimod cream and reflectance-mode confocal microscopy as adjunct modalities to Mohs micrographic surgery for treatment of basal cell carcinoma. Dermatol Surg. 2004 Dec;30(12 Pt 1):1462–1469.
Sterry W, Ruzicka T, Herrera E, et al. Imiquimod 5% cream for the treatment of superficial and nodular basal cell carcinoma: randomized studies comparing low-frequency dosing with and without occlusion. Br J Dermatol. 2002;147(6):1227–1236.
“5-fluorouracil” www.drugs.com, last updated December 11, 2008.
Smitha P, Raghavendra R, Sripathi H, et al. Successful use of imiquimod 5% cream in Bowen’s disease. Indian J Dermatol Leprol. 2007 Nov–Dec;73(6):423–425.
Ondo Al, Mings SM, Pestak RM, et al. Topical combination therapy for cutaneous squamous cell carcinoma in situ with 5-fluorouracil cream and imiquimod cream in patients who have failed topical monotherapy. J Am Acad Dermatol. 2006 Dec;55(6):1092–1094.
Thissen MR, Kuijpers DI, Krekis GA. Local immune modulator (imiquimod 5% cream) as adjuvant treatment after incomplete Mohs micrographic surgery for large, mixed type basal cell carcinoma: a report of 3 cases. J Drugs Dermatol. 2006 May;5(5):461–464.
Salasche SJ. Curettage and electrodessication in the treatment of midfacial basal cell epithelioma. J Am Acad Dermatol. 1983;8:496–503.
Silverman MK, Kopf AW, Gladstein AH, et al. Recurrence rates of treated basal cell carcinomas, part 4: x-ray therapy. J Dermatol Surg Oncol. 1992;18:549–554.
Suhge d’Aubermont PC, Bennett RG. Failure of curettage and electrodessication for removal of basal cell carcinoma. Arch Dermatol. 1984;120:1456–1460.
Rigel DS, Torres AM, Ely H. Imiquimod 5% cream following curettage without electrodessication for basal cell carcinoma: preliminary report. J Drugs Dermatol. 2008;7(Suppl 1):15–16.
Nercessian OA, Wu H, Nazarian D, et al. Intraoperative pacemaker dysfunction caused by the use of electrocautery during a total hip arthroplasty. J Arthroplasty. 1998;13:599–602.
Levine PA, Balady GJ, Lazar HL, et al. Electrocautery and pacemakers: management of the paced patient subject to electrocautery. Ann Thoracic Surg. 1986;41:313–317.
Snow JS, Kalenderian D, Clasacco JA, et al. Implanted devices and electromagnetic interference: case presentations and review. J Invasive Cardiol. 1995;7:25–32.
Neville JA, Williford PM, Jorizzo JL. Pilot study using topical imiquimod 5% cream in the treatment of nodular basal cell carcinoma after initial treatment with curettage. J Drugs Dermatol. 2007 Sep;6(9):910–914.
Nelson CG, Spencer J, Nelson CG Jr. A single-arm, open label efficacy and tolerability study of diclofenac sodium 3% gel for the treatment of actinic keratosis of the upper and lower lip. J Drugs Dermatol. 2007 July;6(7):712–717.
Ulrich C, Forschner T, Ulrich M, et al. Management of actinic cheilitis using diclofenac 3% gel: a report of six cases. Br J Dermatol. 2007 May;156(Suppl 3):43–46.
Epstein E. Treatment of lip keratoses (actinic cheilitis) with topical fluorouracil. Arch Dermatol. 1977 July;113:906–908.
Smith KJ, Germain M, Yeager J, et al. Topical 5% imiquimod for the therapy of actinic cheilitis. JAAD. 2002 Oct;47(4):497–501.
Biasi MA, Giammaria D, Balestrazzi E. Immunotherapy with imiquimod 5% cream for eyelid nodular basal cell carcinoma. Am J Ophthalmol. 2005 Dec;140(6):1136–1139.
Choontanom R, Thanos S, Busse H, et al. Treatment of basal cell carcinoma of the eyelids with 5% topical imiquimod: a 3-year follow-up study. Graefes Arch Clin Exp Ophthalmol. 2007 Mar;245:1217–1220.
Leppala J, Kaarniranta K, Uuusitalo H, et al. Imiquimod in the treatment of eyelid basal cell carcinoma. Acta Ophthalmol Scand. 2007 Aug;85(5):566–568.
Galentine P, Sloas H, Hargett N, et al. Bilateral cicatricial ectropion following topical administration of 5-fluorouracil. Ann Ophthalmol. 1981 May;13(5):575–577.
Hecker D, Hacker SM, Ramos-Caro FA, et al. Temporary ectropion due to topical fluorouracil. Cutis. 1994 Mar;53(3):137–138.
Lewis JE. Temporary ectropion due to topical fluorouracil. Int J Dermatol. 1997 Jan;36(1):79.
Poothullil AM, Colby KA. Topical medical therapies for ocular surface tumors. Semin Ophthalmol. 2006 Jul–Sep;21(3):161–169.
Danielsen AG, Sand C, Weisman K. Treatment of Bowen’s disease of the penis with imiquimod 5% cream. Clin Exp Dermatol. 2003 Nov;28(Suppl 1):7–9.
Micali G, Nasca MR, Tedeschi A. Topical treatment of intraepithelial penile carcinoma with imiquimod. Clin Exp Dermatol. 2003 Nov;28(Suppl 1):4–6.
Orengo I, Rosen T, Guill C. Treatment of squamous cell carcinoma in situ of the penis with 5% imiquimod cream: a case report. J Am Acad Dermatol. 2002 Oct;47(4):225–228.
Goorney BP, Polori R. A case of Bowenoid Papulosis of the penis successfully treated with topical imiquimod cream 5%. Int J STD AIDS. 2004 Dec;15(12):833–835.
Bernstein DI, Spruance SL, Arora SS, et al. Evaluation of imiquimod 5% cream to modify the natural history of herpes labialis: a pilot study. Clin Infect Dis. 2005 Sep 15;41(6):808–814. Epub 2005 Aug 10
Schroeder TL, Sengelmann RD. Squamous cell carcinoma in situ of the penis successfully treated with imiquimod 5% cream. J Am Acad Dermatol. 2002 Apr;46(4):545–548.
Ferreres JR, Macaya A, Jucgla A, et al. Hundreds of basal cell carcinomas in a Gorlin-Goltz syndrome patient cured with imiquimod 5% cream. J Eur Acad Dermatol Venereol. 2006 Aug;20(7):877–878.
Micali G, Lacarrubba F, Nasca MR, et al. The use of imiquimod 5% cream for the treatment of basal cell carcinoma as observed in Gorlin’s syndrome. Clin Exp Dermatol. 2003 Nov;28(Suppl 1):19–23.
Stockfleth E, Ulrich C, Hauschild A, et al. Successful treatment of basal cell carcinomas in a nevoid basal cell carcinoma syndrome with topical 5% imiquimod. Eur J Dermatol. 2002 Nov–Dec;12(6):569–572.
Vereecken P, Monsieur E, Petein M, et al. Topical application of imiquimod for the treatment of high-risk facial basal cell carcinoma in Gorlin syndrome. J Dermatolog Treat. 2004 Apr;15(2):120–121.
Kovach BT, Stasko T. Use of topical immunomodulators in organ transplant recipients. Dermatol Ther. 2005;18:19–27
Prinz BM, Hafner J, Dummer R, et al. Treatment of Bowen’s disease with imiquimod 5% cream in transplant patients. Transplantation. 2004;77(5):790–791.
Smith KJ, Germain M, Skelton H. Squamous cell carcinoma in situ (Bowen’s disease) in renal transplant patients treated with 5% imiquimod and 5% 5-fluorouracil therapy. Dermatol Surg. 2001;27(6):561–564.
Vidal D, Alomar A. Efficacy of imiquimod 5% cream for basal cell carcinoma in transplant patients. Clin Exp Dermatol. 2004;29(3):237–239.
Ulrich C, Stockfelth E. Safety and efficacy of imiquimod 5% cream applied once daily 3 days per week for the treatment of actinic keratoses in immunosuppressed organ transplant recipients-results of a double blinded, European multi-centre study. J Am Acad Dermatol. 2007 Jan P2304 poster presentation.
Clayton AS, Stasko T. Treatment of nonmelanoma skin cancer in organ transplant recipients: review of responses to a survey. J Am Acad Dermatol. 2003 Sep;49(3):413–416.
Torres A, Marra D, Desai TD, et al. Imiquimod 5% cream does not induce tumor skip areas in the topical treatment of basal cell carcinoma. Unpublished data.
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Torres, A., Desai, T. (2009). Topical Therapies for Nonmelanoma Skin Cancers. In: MacFarlane, D.F. (eds) Skin Cancer Management. Springer, New York, NY. https://doi.org/10.1007/978-0-387-88495-0_2
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