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Cytotoxicity of Photoactive Nanoparticles

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Safety of Nanoparticles

Part of the book series: Nanostructure Science and Technology ((NST))

Abstract

This chapter describes the cytotoxicity of photoactive materials (specifically, quantum dots, noble metal nanoparticles (including gold and silver), and fluorescent silica nanoparticles). A thorough representation of in vitro and in vivo toxicity studies is presented. Since the toxicity on photoactive nanomaterials described in this chapter has developed rapidly and has attracted a great amount of interest, it is expected that many novel developments and applications of photoactive nanomaterials will ensue in the near future.

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Abbreviations

Ag NPs:

Silver nanoparticles

Au NPs:

Gold nanoparticles

BSA:

Bovine serum albumin

CdSe:

Cadmium selenide

CdTe:

Cadmium telluride

EC50 :

Effective concentration

GSH:

Glutathione

LC50 :

Lethal concentration

MMP:

Mitochondrial membrane potential

MTT:

3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide

MPA:

Mercaptopropionic acid

MUA:

Mercapto-undecanoic acid

NAC:

N-Acetylcysteine

NPs:

Nanoparticles

PEG:

Polyethylene glycol

QDs:

Quantum dots

ROS:

Reactive oxygen species

Silica NPs:

Silica nanoparticles

SOPC:

Phosphotidylcholine

SOPS:

Phosphotidylserine

ZnS:

Zinc sulfide.

References

  • Braydich-Stolle L, Hussain S, Schlager JJ, Hofmann MC (2005) In vitro cytotoxicity of nanoparticles in Mammalian germline stem cells. Toxicol Sci 88:412–419

    Article  CAS  Google Scholar 

  • Cao YC, Jin R, Mirkin CA (2002) Nanoparticles with Raman spectroscopic fingerprints for DNA and RNA detection. Science 297:1536–1540

    Article  CAS  Google Scholar 

  • Cao YC, Jin R, Nam JM, Thaxton CS, Mirkin CA (2003) Raman dye-labeled nanoparticle probes for proteins. J Am Chem Soc 125:14676–14677

    Article  CAS  Google Scholar 

  • Cao YW, Jin R, Mirkin CA (2001) DNA-modified core-shell Ag/Au nanoparticles. J Am Chem Soc 123:7961–7962

    Article  CAS  Google Scholar 

  • Chang J,Wu H, Chen H, Ling Y, TanW(2005) Oriented assembly of Au nanorods using biorecognition system. Chem Commun 8:1092–1094

    Google Scholar 

  • Derfus AM, Chan WCW, Bhatia SN (2004) Probing the cytotoxicity of semiconductor quantum dots. Nano Lett 4:11–18

    Article  CAS  Google Scholar 

  • Dubertret B, Skourides P, Norris DJ, Noireaux V, Brivanlou AH, Libchaber A (2002) In vivo imaging of quantum dots encapsulated in phospholipid micelles. Science 298:1759–1762

    Article  CAS  Google Scholar 

  • Goodman CM, McCusker CD, Yilmaz T, Rotello VM (2004) Toxicity of gold nanoparticles functionalized with cationic and anionic side chains. Bioconjug Chem 15:897–900

    Article  CAS  Google Scholar 

  • Green M, Howman E (2005) Semiconductor quantum dots and free radical induced DNA nicking. Chem Commun: 121–123

    Google Scholar 

  • He XX, Wang K, Tan W, Liu B, Lin X, He C, Li D, Huang S, Li J (2003) Bioconjugated nanoparticles for DNA protection from cleavage. J Am Chem Soc 125:7168–7169

    Article  CAS  Google Scholar 

  • Hoshino A, Fujioka K, Oku T, Suga M, Sasaki YF, Ohta T, Yasuhara M, Suzuki K, Yamamoto K (2004) Physicochemical properties and cellular toxicity of nanocrystal quantum dots depend on their surface modification. Nano Lett 4:2163–2169

    Article  CAS  Google Scholar 

  • Hussain SM, Hess KL, Gearhart JM, Geiss KT, Schlager JJ (2005) In vitro toxicity of nanoparticles in BRL 3A rat liver cells. Toxicol In Vitro 19:975–983

    Article  CAS  Google Scholar 

  • Ito S, Yoshikawa H, Masuhara H (2001) Optical patterning and photochemical fixation of polymer nanoparticles on glass substrates. Appl Phys Lett 78:4046

    Article  CAS  Google Scholar 

  • Kirchner C, Liedl T, Kudera S, Pellegrino T, Munoz JA, Gaub HE, Stolzle S, Fertig N, Parak WJ (2005) Cytotoxicity of colloidal CdSe and CdSe/ZnS nanoparticles. Nano Lett 5:331–338

    Article  CAS  Google Scholar 

  • Kwon SS, Nam YS, Lee JS, Ku BS, Han SH, Lee JY, Chang IS (2002) Preparation and characterization of coenzyme Q10-loaded PMMA nanoparticles by a new emulsification process based on microfluidization. Colloids and Surfaces, A: Physicochemical and Engineering Aspects 210:95–104

    Article  CAS  Google Scholar 

  • Lagerholm CB, Wang M, Ernst LA, Ly DH, Liu H, Bruchez MP, Waggoner AS (2004) Multicolor coding of cells with cationic peptide coated quantum dots. Nano Lett 4:2019–2022

    Article  CAS  Google Scholar 

  • Li D, He XX, Wang K, He C (2002) Detecting on toxicity of series silica shell inorganic nanoparticles to cells. J Hunan Univ 29:1–6

    CAS  Google Scholar 

  • Liang S, Pierce D, Amiot C, Zhao X (2005) Photoactive nanomaterials for sensing trace analytes in biological samples. Synth React Inorg Met-Org and Nano Met Chem 35:661–668

    Article  CAS  Google Scholar 

  • Lovri´c J, Bazzi HS, Cuie Y, Fortin GR,Winnik FM, Maysinger D (2005) Differences in subcellular distribution and toxicity of green and red emitting CdTe quantum dots. J Mol Med 83:377–385

    Google Scholar 

  • Luo D, Han E, Belcheva N, SaltzmanWM(2004) A self-assembled, modular DNA delivery system mediated by silica nanoparticles. J Control Release 95:333–341

    Google Scholar 

  • Michalet X, Pinaud FF, Bentolila LA, Tsay JM, Doose S, Li JJ, Sundaresan G, Wu AM, Gambhir SS, Weiss S (2005) Quantum dots for live cells, in vivo imaging, and diagnostics. Science 307:538–544

    Article  CAS  Google Scholar 

  • Mirkin CA, Letsinger RL, Mucic RC, Storhoff JJ (1996) A DNA-based method for rationally assembling nanoparticles into macroscopic materials. Nature 382:607–609

    Article  CAS  Google Scholar 

  • Santra S, Yang H, Holloway PH, Stanley JT, Mericle RA (2005) Synthesis of water-dispersible fluorescent, radio-opaque, and paramagnetic CdS:Mn/ZnS quantum dots: a multifunctional probe for bioimaging. J Am Chem Soc 127:1656–1657

    Article  CAS  Google Scholar 

  • Shiohara A, Hoshino A, Hanaki K, Suzuki K, Yamamoto K (2004) On the cyto-toxicity caused by quantum dots. Microbiol Immunol 48:669–675

    CAS  Google Scholar 

  • Wang L, Yang C, Tan W (2005) Dual-luminophore-doped silica nanoparticles for multiplexed signaling. Nano Lett 5:37–43

    Article  CAS  Google Scholar 

  • Yi DK, Selvan ST, Lee SS, Papaefthymiou GC, Kundaliya D, Ying JY (2005) Silica-coated nanocomposites of magnetic nanoparticles and quantum dots. J Am Chem Soc 127:4990–4991

    Article  CAS  Google Scholar 

  • Zhao X, Dytocio RT, Tan W (2003a) Ultrasensitive DNA detection using highly fluorescent bioconjugated nanoparticles. J Am Chem Soc 125:11474–11475

    Article  CAS  Google Scholar 

  • Zhao X, Hilliard LR, Mechery SJ, Wang Y, Bagwe RP, Jin S, Tan W (2004) A rapid bioassay for single bacterial cell quantitation using bioconjugated nanoparticles. Proc Natl Acad Sci USA 101:15027–15032

    Article  CAS  Google Scholar 

  • Zhao X, Tapec-Dytioco R, Wang K, Tan W (2003b) Collection of trace amounts of DNA/mRNA molecules using genomagnetic nanocapturers. Anal Chem 75:3476–3483

    Article  CAS  Google Scholar 

  • Zhou C, Zhao Y, Jao T, Winnik MA, Wu C (2002) Photoinduced aggregation of polymer nanoparticles in a dilute nonaqueous dispersion. J Phys Chem B 106:1889–1897

    Article  CAS  Google Scholar 

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Acknowledgements

This work was partially supported by Society for Analytical Chemists of Pittsburgh Starter Grant; New Faculty Scholar Awards and Faculty Research Seed Money Awards at the University of North Dakota; and Startup fund from NSF EPSCoR, EPA EPSCoR and BRIN at the University of North Dakota.

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Authors and Affiliations

  1. Department of Chemistry, University of North Dakota, Grand Forks, ND, 58202, USA

    Yuhui Jin & Xiaojun Zhao

Authors
  1. Yuhui Jin
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  2. Xiaojun Zhao
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Corresponding author

Correspondence to Yuhui Jin .

Editor information

Editors and Affiliations

  1. School of Engineering, Brown University, 182 Hope Street, Providence, 02912, Rhode Island, USA

    Thomas J. Webster

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Jin, Y., Zhao, X. (2009). Cytotoxicity of Photoactive Nanoparticles. In: Webster, T. (eds) Safety of Nanoparticles. Nanostructure Science and Technology. Springer, New York, NY. https://doi.org/10.1007/978-0-387-78608-7_2

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