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External Anogenital Premalignant and Malignant Disease

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Skin Cancer after Organ Transplantation

Part of the book series: Cancer Treatment and Research ((CTAR,volume 146))

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The external anogenital area comprises the anus, perianal skin, and the adjacent external genitalia including the vulva and vaginal introitus in the female, and the penis and scrotum in the male. Immunosuppressed organ transplant recipients (OTR) are prone to viral infections, and have an increased incidence of human papillomavirus (HPV) associated premalignant and malignant neoplasms, which specifically target the anogenital tract. The cumulative risk of the development of a solid-organ neoplasm is 5–6% [1–3]. Nearly all of these neoplasms occur on a background of premalignant disease (i.e., carcinoma in situ). The most common presentation of anogenital disease in OTR is condyloma accuminata or genital viral warts and these are regarded as a marker of immunosuppression in this group.

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Authors and Affiliations

  1. Barts and the London NHS Trust, London, E1 1BB, United Kingdom

    Karen L. Gibbon

  2. The Royal London Hospital,Whitechapel, London, E1 1BB, United Kingdom

    Arucha L. Ekeowa-Anderson

  3. College of Medicine, Dentistry and Nursing, University of Dundee, Ninewells Hospital & Medical School, Dundee DD1 9YS, United Kingdom

    Irene M. Leigh

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  1. Klinik für Dermatologie Venerologie und Allergologie, Charité - Universitätsklinikum Berlin Charite Campus Mitte Klinik und Poliklinik for Dermatologie, Charitéplatz 1, 10117 Berlin, Germany

    Eggert Stockfleth MD, PhD  & Claas Ulrich  & 

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Gibbon, K.L., Ekeowa-Anderson, A.L., Leigh, I.M. (2009). External Anogenital Premalignant and Malignant Disease. In: Stockfleth, E., Ulrich, C. (eds) Skin Cancer after Organ Transplantation. Cancer Treatment and Research, vol 146. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-78574-5_23

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