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New Trends in the Susceptibility to Melanoma

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Skin Cancer after Organ Transplantation

Part of the book series: Cancer Treatment and Research ((CTAR,volume 146))

In contrast with cutaneous squamous cell carcinomas, the risk for development of melanoma does not appear to be greatly increased after solid organ transplantation, except for the rare case of donor-derived melanoma. The clinical aspects of melanoma in organ transplant recipients are discussed elsewhere, but it would seem that genetic susceptibility to melanoma is likely to be of similar relevance to the immunosuppressed individual as to the immunocompetent individual. Because the outcome of melanoma, particularly thicker melanomas, is worse after transplantation (Matin et al., in press), patients who come from melanoma-prone families or who have a history of multiple melanomas must be carefully counselled before transplantation. Extremely close skin surveillance and a low threshold for biopsy of melanocytic lesions would be advisable.

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Authors and Affiliations

  1. Department of Dermatology, Laboratoire de Biochimie Hormonale et Génétique, IFR02, Hopital Bichat-Claude Bernard, 46rue Henri Huchard, Paris, France

    Nadem Soufir

  2. Department de Biochemie Hormonale et Génétique, Hôpital Bichat, Paris, France

    Bernard Grandchamp

  3. Department of Dermatology, Hôpital,Saint-Louis, Policlinique de dermatologie, 1 avenue C Vellefaux, Paris, France

    Nicole Basset-Seguin

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  1. Nadem Soufir
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  1. Klinik für Dermatologie Venerologie und Allergologie, Charité - Universitätsklinikum Berlin Charite Campus Mitte Klinik und Poliklinik for Dermatologie, Charitéplatz 1, 10117 Berlin, Germany

    Eggert Stockfleth MD, PhD  & Claas Ulrich  & 

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Soufir, N., Grandchamp, B., Basset-Seguin, N. (2009). New Trends in the Susceptibility to Melanoma. In: Stockfleth, E., Ulrich, C. (eds) Skin Cancer after Organ Transplantation. Cancer Treatment and Research, vol 146. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-78574-5_19

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