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Biomimetic Coatings and Their Biological Functionalization

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Thin Calcium Phosphate Coatings for Medical Implants

Abstract

The biomimetic coating technique can be used to deposit layers of calcium phosphate (CaP) on medical devices to improve their osteoconductivity and osseointegration.The inorganic layer generated is akin to mineralized bone matrix and can be degraded as such. The biomimetic coating technique involves the nucleation and growth of bone-like crystals on a pretreated substrate by immersing it in a supersaturated solution of CaP under physiological conditions of temperature (37°C) and pH (7.4). The method, originally developed by Kokubo and his co-workers in 1990, has since undergone improvement and refinement by several groups of investigators. Biomimetic coatings are valuable in that they can serve as a vehicle for the slow, sustained release of osteogenic agents at the site of implantation. This attribute is rendered possible by the near-physiological conditions under which these coatings are prepared, which permits the incorporation of bioactive agents into the inorganic crystal latticework rather than their superficial adsorption on preformed layers. In addition, the biomimetic coating technique can be applied to implants of an organic as well as of a metallic nature and to those with irregular surface geometries, which is not possible using conventional methodologies.

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Authors and Affiliations

  1. Section of Oral Implantology, Department of Oral Function, Academic Centre of Dentistry Amsterdam (ACTA), Louwesweg 1, 1067 EA, Amsterdam, The Netherlands

    Yuelian Liu

  2. ITI Research Institute for Dental and Skeletal Biology, University of Bern, Switzerland

    Yuelian Liu

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  1. Yuelian Liu
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  2. Ernst B. Hunziker
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Correspondence to Yuelian Liu .

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    Liu, Y., Hunziker, E.B. (2009). Biomimetic Coatings and Their Biological Functionalization. In: León, B., Jansen, J. (eds) Thin Calcium Phosphate Coatings for Medical Implants. Springer, New York, NY. https://doi.org/10.1007/978-0-387-77718-4_11

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