Abstract
A 2005 report from the American Association of Poison Control Centers indicates that there were over 200,000 exposures to caustic substances in the form of household and industrial products, including acids (sulfuric acid, hydrochloric acid), alkalis (potassium hydroxide, sodium hydroxide), and other agents. While the majority of cases involved exposure of a body surface, such as the face, eyes, and extremities, ingestion of the caustic agent was the leading cause of death [1].
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References
Lai MW, Klein-Schwartz W, Rodgers GC, et al (2006) 2005 Annual Report of the American Association of Poison Control Centers’ National Poisoning and Exposure Database. Clin Toxicol 44:803–932
Loeb-Abram PM, Eisenstein M (1998) Caustic injury to the upper gastrointestinal tract. In: Feldman M, Scharschmidt BF, Sleisenger MH, Fordtran JS (eds) Sleisenger and Fordtran’s Gastrointestinal and Liver Disease, 6th edition. W. B. Saunders Company, Philadelphia, pp 335–342
Gorman RL, Khing-Maung-Gyi MT, Klein-Schwartz W, et al (1992) Initial symptoms as predictors of esophageal injury in alkaline corrosive ingestions. Am J Emerg Med 10:189–194
Dale Browne J, Thompson JN (2005) Caustic ingestion. In: Cummings CW, Haughey BH, Thomas JR, Harker LA, Flint PW (eds) Cummings Otolaryngology: Head and Neck Surgery, 4th ed. Mosby, New York, pp 1869–1872
Zargar SA, Kochhar R, Nagi B, Mehta S, Mehta SK (1992) Ingestion of strong corrosive alkalis: spectrum of injury to upper gastrointestinal tract and natural history. Am J Gastroenterol 87:337–341
Kynaston JA, Patrick MK, Shepherd RW, Raivadera PV, Cleghorn GI (1989) The hazards of automatic-dishwasher detergent. Med J Aust 151:155
Mattos GM, Lopes DD, Mamede RC, Ricz H, Mello-Filho FV, Neto JB (2006) Effects of time of contact and concentration of caustic agent on generation of injuries. Laryngoscope 116: 456–460
Havanond C (2002) Is there a difference between the management of grade 2b and 3 corrosive gastric injuries? J Med Assoc Thai 85:340–344
Sivilotti MLA, Ford M (2000) Alkali ingestions. In: Ford M, Delaney KA, Ling L, Erickson T (eds) Clinical Toxicology, 1st ed. W. B. Saunders Company, Philadelphia, pp 1002–1007
Hoffman RS, Howland MA, Kamerow HN, Goldfrank LR (1989) Comparison of titratable acid/alkaline reserve and pH in potentially caustic household products. J Toxicol Clin Toxicol 27:241–261
Boldt GB, Carroll RG (1996) Titratable acid/alkaline reserve is not predictive of esophageal perforation risk after caustic exposure. Am J Emerg Med 14:106–108
Kirsh MM, Ritter F (1976) Caustic ingestion and subsequent damage to the oropharyngeal and digestive passages. Ann Thorac Surg 21:74–82
Penner GE (1980) Acid ingestion: Toxicity and treatment. Ann Emerg Med 9:374–379
Ritter FN, Newman MH, Newman DE (1968) A clinical and experimental study of corrosive burns of the stomach. Ann Otol Rhin Laryngol 77:830–842
Clifton JC II (2001) Acid ingestions. In: Ford M, Delaney KA, Ling L, Erickson T (eds) Clinical Toxicology, 1st ed. W. B. Saunders Company, Philadelphia, pp 1009–1018
Gunel E, Caglayan F, Caglayan O, Akillioglu I (1999) Reactive oxygen radical levels in caustic esophageal burns. J Pediatr Surg 34:405–407
Homan CS, Maitra SR, Lane BP, Thode HC, Sable M (1994) Therapeutic effects of water and milk for acute alkali injury of the esophagus. Ann Emerg Med 24:14–20
Homan CS, Maitra SR, Lane BP, Thode HC Jr, Finkelshteyn J, Davidson L (1995) Effective treatment for acute alkali injury to the esophagus using weak-acid neutralization therapy: an ex-vivo study. Acad Emerg Med 2:952–958
Rumack BH, Burrington JD (1977) Caustic ingestions: a rational look at diluents. Clin Toxicol 11:27–34
Bronsted JN (1923) Some remarks on the concept of acids and bases. Reel Trav Chim Pays Bas 42:718–728
Cardona JC, Daly JF (1971) Current management of corrosive esophagitis: An evaluation of results in 239 cases. Ann Otol Rhinol Laryngol 80:521–526
Rubin MM, Jui V, Cozzi GM (1989) Treatment of caustic ingestion. J Oral Maxillofac Surg 47: 286–290
Zargar SA, Kochhar R, Nagi B, Mehta S, Mehta SK (1989) Ingestion of corrosive acids: Spectrum of injury to upper gastrointestinal tract and natural history. Gastroenterology 97:702–707
Poley JW, Steyerberg EW, Kuipers EJ, et al (2004) Ingestion of acid and alkaline agents: outcome and prognostic value of early upper endoscopy. Gastrointest Endosc 60:372–377
Litovitz TL, Schmitz BF (1992) Ingestion of cylindrical and button batteries: An analysis of 2382 cases. Pediatrics 89:747–757
Barber TE, Menke RD (1984) The relationship of ingested iron to the absorption of mercuric oxide. Am J Emerg Med 2:500–503
Anderson WJ, Anderson JR (1988) Hydrofluoric acid burns of the hand: Mechanism of injury and treatment. J Hand Surg 13A:52–57
Sadove R, Hainsworth D, Van Meter W (1990) Total body immersion in hydrofluoric acid. South Med J 83:698–700
Edinburg M, Swift R (1989) Hydrofluoric acid burns of the hands: A case report and suggested management. Aust NZ J Surg 59:88–91
Kirkpatrick JJ, Enion DS, Burd DA (1995) Hydrofluoric acid burns: A review. Burns 21: 483–493
Klasaer AE, Scalzo AJ, Blume C, Johnson P, Thompson MW (1996) Marked hypocalcemia and ventricular fibrillation in two pediatric patients exposed to a fluoride-containing wheel cleaner. Ann Emerg Med 28:713–718
Mullett T, Zoeller T, Bingham H, et al (1987) Fatal hydrofluoric acid cutaneous exposure with refractory ventricular fibrillation. J Burn Care Rehabil 8:216–219
Cardona J, Boussemart T, Berthier M, Oriot D (1993) [Accidental bleach ingestion in children: Results of a survey of 11 anti-poison centres. Proposals for management.] Pediatrie 48:705–709
Ward MJ, Routledge PA (1988) Hypernatraemia and hyperchloraemic acidosis after bleach ingestion. Hum Toxicol 7:37–38
Davids PH, Bartelsman JF, Tilanus HW, van Lanschot JJ (2001) [Consequences of caustic damage of the esophagus]. Ned Tijdschr Geneeskd 145:2105–2108
Muhletaler CA, Gerlock AJ Jr, de Soto L, Halter SA (1980) Acid corrosive esophagitis: Radiographic findings. Am J Roentgenol 134:1137–1140
Hawkins DB, Demeter MJ, Barnett TE (1980) Caustic ingestion: Controversies in management: A review of 214 cases. Laryngoscope 90:98–109
Bautista Casasnovas A, Estevez Martinez E, Varela Cives R, Villanueva Jeremias A, Tojo Sierra R, Cadranel S (1997) A retrospective analysis of ingestion of caustic substances by children: Ten-year statistics in Galicia. Eur J Pediatr 156:410–414
Gumaste VV, Dave PB (1992) Ingestion of corrosive substances by adults. Am J Gastroenterol 87:1–5
Waldeyer W (1908) Die Magenstrasse. Sitzungsber K Preuss, aka d Wissench Gesammtsitz 29: 595–606
Zargar SA, Kochhar R, Mehta S, Mehta SK (1991) The role of fiberoptic endoscopy in the management of corrosive ingestion and modified endoscopic classification of burns. Gastrointest Endosc 37:165–169
Johnson EE (1963) A study of corrosive esophagitis. Laryngoscope 73:1651–1696
Hopkins RA, Postlethwait RW (1981) Caustic burns and carcinoma of the esophagus. Ann Surg 194:146–148
Bautista A, Varela R, Villanueva A, Estevez E, Tojo R, Cadranel S (1996) Motor function of the esophagus after caustic burn. Eur J Pediatr Surg 6:204–207
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Osman, M., Granger, D.N. (2008). Pathophysiology of Caustic Ingestion. In: Vincent, JL. (eds) Intensive Care Medicine. Springer, New York, NY. https://doi.org/10.1007/978-0-387-77383-4_16
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DOI: https://doi.org/10.1007/978-0-387-77383-4_16
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