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Clinical Cupping: Laminar and Prelaminar Components

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Abstract

While glaucomatous damage to the visual system likely includes important pathophysiologies within the retinal ganglion cell (RGC) body, photoreceptors, lateral geniculate body, and visual cortex, strong evidence suggests that damage to the retinal ganglion cell axons within the lamina cribrosa of the optic nerve head (ONH) is the central pathophysiology underlying glaucomatous vision loss. Recent studies in the monkey and rat support the importance of the ONH, by describing profound alterations within the prelaminar, laminar, and peripapillary scleral tissues of the ONH at the earliest detectable stage of experimental glaucoma.

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Acknowledgement

Portions of this chapter have appeared previously in two publications.24,69

Supported in part by USPHS grant R01EY011610 (CFB) from the National Eye Institute, National Institutes of Health, Bethesda, Maryland; unrestricted research support from Heidelberg Engineering; a grant from the American Health Assistance Foundation, Rockville, Maryland (CFB); a grant from The Whitaker Foundation, Arlington, Virginia (CFB); a Career Development Award (CFB) from Research to Prevent Blindness, Inc., New York, New York and unrestricted support from The Sears Trust, Mexico MO.

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  1. Optic Nerve Head Research Laboratory, Discoveries in Sight Research Laboratories, Devers Eye Institute, Legacy Health System, Portland, OR, USA

    Claude F. Burgoyne MD

  2. Department of Biomedical Engineering, Tulane University, New Orleans, LA, USA

    Hongli Yang MS

  3. Ocular Biomechanics Laboratory, Discoveries in Sight Research Laboratories, Devers Eye Institute, Legacy Health System, Portland, OR, USA

    J. Crawford Downs PhD

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  1. Claude F. Burgoyne MD
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  2. Hongli Yang MS
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  3. J. Crawford Downs PhD
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  1. 2889 10th Avenue, N., Palm Springs, 33461, USA

    Paul N. Schacknow

  2. Casey Eye Institute, Dept. Ophthalmology, Oregon Health & Sciences University, SW. Terwilliger Blvd. 3375, Portland, 97201-4197, USA

    John R. Samples

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Burgoyne, C.F., Yang, H., Downs, J.C. (2010). Clinical Cupping: Laminar and Prelaminar Components. In: Schacknow, P., Samples, J. (eds) The Glaucoma Book. Springer, New York, NY. https://doi.org/10.1007/978-0-387-76700-0_16

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