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Dysnatremias: Diagnosis and Treatment

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References

  • Dunn, F.L., Brennan, T.J., Nelson, A.E., Robertson, G.L. The role of blood osmolality and volume in regulating vasopressin secretion in the rat. J. Clin. Invest. 1973; 52(12):3212–3219.

    PubMed  CAS  Google Scholar 

  • Heilig, C.W., Stromski, M.E., Blumenfeld, J.D., Lee, J.P., Gullans, S.R. Characterization of the major brain osmolytes that accumulate in salt-loaded rats. Am. J. Physiol. 1989; 257(6 Pt 2):F1108–1116.

    PubMed  CAS  Google Scholar 

  • Lien, Y.H., Shapiro, J.I., Chan, L. Effects of hypernatremia on organic brain osmoles. J. Clin. Invest. 1990; 85(5):1427–1435.

    PubMed  CAS  Google Scholar 

  • Ayus, J.C., Armstrong, D.L., Arieff, A.I. Effects of hypernatraemia in the central nervous system and its therapy in rats and rabbits. J. Physiol. 1996; 492 (Pt 1):243–255.

    PubMed  CAS  Google Scholar 

  • Moritz, M.L., Ayus, J.C. The changing pattern of hypernatremia in hospitalized children. Pediatrics 1999; 104(3 Pt 1):435–439.

    Article  PubMed  CAS  Google Scholar 

  • Achinger, S.G., Moritz, M.L., Ayus, J.C. Dysnatremias: Why are patients still dying? South Med. J. 2006; 99(4):1–12.

    Article  Google Scholar 

  • Ayus, J.C., Krothapalli, R.K. Hyperglycemia (HG) associated with non-diabetic hypernatremia (NDH) patients. J. Am. Soc. Nephrol. 1990; 1:317A.

    Google Scholar 

  • Renneboog, B., Sattar, L., Decaux, G. Determination of thresholds for the attention and gait deficits encountered in chronic hyponatremia. J. Am. Soc. Nephrol. 2006; 17:37A (Abstract).

    Article  CAS  Google Scholar 

  • Ayus, J.C., Arieff, A.I. Chronic hyponatremic encephalopathy in postmenopausal women: Association of therapies with morbidity and mortality. JAMA 1999; 281(24):2299–2304.

    Article  PubMed  CAS  Google Scholar 

  • Arieff, A.I., Ayus, J.C. Endometrial ablation complicated by fatal hyponatremic encephalopathy. JAMA 1993; 270(10):1230–1232.

    Article  PubMed  CAS  Google Scholar 

  • Arieff, A.I., Ayus, J.C. Pathogenesis of hyponatremic encephalopathy. Current concepts. Chest 1993; 103(2):607–610.

    PubMed  CAS  Google Scholar 

  • Ayus, J.C., Levine, R., Arieff, A.I. Fatal dysnatraemia caused by elective colonoscopy. BMJ 2003; 326(7385):382–384.

    Article  PubMed  Google Scholar 

  • Arieff, A.I., Ayus, J.C., Fraser, C.L. Hyponatraemia and death or permanent brain damage in healthy children. BMJ 1992; 304(6836):1218–1222.

    PubMed  CAS  Google Scholar 

  • Ayus, J.C., Krothapalli, R.K., Arieff, A.I. Treatment of symptomatic hyponatremia and its relation to brain damage. A prospective study. N. Engl. J. Med. 1987; 317(19):1190–1195.

    Article  PubMed  CAS  Google Scholar 

  • Nielsen, S., Nagelhus, E.A., Amiry-Moghaddam, M., Bourque, C., Agre, P., Ottersen, O.P. Specialized membrane domains for water transport in glial cells: High-resolution immunogold cytochemistry of aquaporin-4 in rat brain. J. Neurosci. 1997; 17(1):171–180.

    PubMed  CAS  Google Scholar 

  • Agre, P., Preston, G.M., Smith, B.L., et al. Aquaporin CHIP: The archetypal molecular water channel. Am. J. Physiol. 1993; 265(4 Pt 2):F463–476.

    PubMed  CAS  Google Scholar 

  • Nielsen, S., Smith, B.L., Christensen, E.I., Agre, P. Distribution of the aquaporin CHIP in secretory and resorptive epithelia and capillary endothelia. Proc. Natl. Acad. Sci. USA 1993; 90(15):7275–7279.

    Article  PubMed  CAS  Google Scholar 

  • Simard, M., Arcuino, G., Takano, T., Liu, Q.S., Nedergaard, M. Signaling at the gliovascular interface. J. Neurosci. 2003; 23(27):9254–9262.

    PubMed  CAS  Google Scholar 

  • Amiry-Moghaddam, M., Ottersen, O.P. The molecular basis of water transport in the brain. Nat. Rev. Neurosci. 2003; 4(12):991–1001.

    PubMed  CAS  Google Scholar 

  • Dolman, D., Drndarski, S., Abbott, N.J., Rattray, M. Induction of aquaporin 1 but not aquaporin 4 messenger RNA in rat primary brain microvessel endothelial cells in culture. J. Neurochem. 2005; 93(4):825–833.

    Article  PubMed  CAS  Google Scholar 

  • Abbott, N.J., Ronnback, L., Hansson, E. Astrocyte-endothelial interactions at the blood-brain barrier. Nat. Rev. Neurosci. 2006; 7(1):41–53.

    Article  PubMed  CAS  Google Scholar 

  • Simard, M., Nedergaard, M. The neurobiology of glia in the context of water and ion homeostasis. Neuroscience 2004; 129(4):877–896.

    Article  PubMed  CAS  Google Scholar 

  • Paulson, O.B., Newman, E.A. Does the release of potassium from astrocyte endfeet regulate cerebral blood flow? Science 1987; 237(4817):896–868.

    Article  PubMed  CAS  Google Scholar 

  • Manley, G.T., Fujimura, M., Ma, T., et al. Aquaporin-4 deletion in mice reduces brain edema after acute water intoxication and ischemic stroke. Nat. Med. 2000; 6(2):159–163.

    Article  PubMed  CAS  Google Scholar 

  • Reulen, H.J., Tsuyumu, M., Tack, A., Fenske, A.R., Prioleau, G.R. Clearance of edema fluid into cerebrospinal fluid. A mechanism for resolution of vasogenic brain edema. J. Neurosurg. 1978; 48(5):754–764.

    PubMed  CAS  Google Scholar 

  • Olson, J.E., Sankar, R., Holtzman, D., James, A., Fleischhacker, D. Energy-dependent volume regulation in primary cultured cerebral astrocytes. J. Cell Physiol. 1986; 128(2):209–215.

    Article  PubMed  CAS  Google Scholar 

  • Melton, J.E., Patlak, C.S., Pettigrew, K.D., Cserr, H.F. Volume regulatory loss of Na, Cl, and K from rat brain during acute hyponatremia. Am. J. Physiol. 1987; 252(4 Pt 2):F661–669.

    PubMed  CAS  Google Scholar 

  • Ayus, J.C., Wheeler, J.M., Arieff, A.I. Postoperative hyponatremic encephalopathy in menstruant women. Ann. Intern. Med. 1992; 117(11):891–897.

    PubMed  CAS  Google Scholar 

  • Moritz, M.L., Ayus, J.C. The pathophysiology and treatment of hyponatraemic encephalopathy: An update. Nephrol. Dial. Transplant 2003; 18(12):2486–2491.

    Article  PubMed  Google Scholar 

  • Xenos, C., Sgouros, S., Natarajan, K. Ventricular volume change in childhood. J. Neurosurg. 2002; 97(3):584–590.

    PubMed  Google Scholar 

  • Sgouros, S., Goldin, J.H., Hockley, A.D., Wake, M.J., Natarajan, K. Intracranial volume change in childhood. J. Neurosurg. 1999; 91(4):610–616.

    PubMed  CAS  Google Scholar 

  • Chen, J.Q., Contreras, R.G., Wang, R., et al. Sodium/potasium ATPase (Na(+), K (+)-ATPase) and ouabain/related cardiac glycosides: A new paradigm for development of anti-breast cancer drugs? Breast Can. Res. Treat. 2006; 96(1):1–15.

    Article  CAS  Google Scholar 

  • Davis, R.A., Kern, F., Jr., Showalter, R., Sutherland, E., Sinensky, M., Simon, F.R. Alterations of hepatic Na+,K+-atpase and bile flow by estrogen: Effects on liver surface membrane lipid structure and function. Proc. Natl. Acad. Sci. USA 1978; 75(9):4130–4134.

    Article  PubMed  CAS  Google Scholar 

  • Fraser, C.L., Kucharczyk, J., Arieff, A.I., Rollin, C., Sarnacki, P., Norman, D. Sex differences result in increased morbidity from hyponatremia in female rats. Am. J. Physiol. 1989; 256(4 Pt 2):R880–885.

    PubMed  CAS  Google Scholar 

  • Arieff, A.I., Kozniewska, E., Roberts, T.P., Vexler, Z.S., Ayus, J.C., Kucharczyk, J. Age, gender, and vasopressin affect survival and brain adaptation in rats with metabolic encephalopathy. Am. J. Physiol. 1995; 268(5 Pt 2):R1143–1152.

    PubMed  CAS  Google Scholar 

  • Fraser, C.L., Sarnacki, P. Na+-K+-ATPase pump function in rat brain synaptosomes is different in males and females. Am. J. Physiol. 1989; 257(2 Pt 1):E284–289.

    PubMed  CAS  Google Scholar 

  • Fraser, C.L., Swanson, R.A. Female sex hormones inhibit volume regulation in rat brain astrocyte culture. Am. J. Physiol. 1994; 267(4 Pt 1):C909–914.

    PubMed  CAS  Google Scholar 

  • Nzerue, C.M., Baffoe-Bonnie, H., You, W., Falana, B., Dai, S. Predictors of outcome in hospitalized patients with severe hyponatremia. J. Natl. Med. Assoc. 2003; 95(5):335–343.

    PubMed  Google Scholar 

  • Vexler, Z.S., Ayus, J.C., Roberts, T.P., Fraser, C.L., Kucharczyk, J., Arieff, A.I. Hypoxic and ischemic hypoxia exacerbate brain injury associated with metabolic encephalopathy in laboratory animals. J. Clin. Invest. 1994; 93(1):256–264.

    Article  PubMed  CAS  Google Scholar 

  • Hochachka, P.W., Buck, L.T., Doll, C.J., Land, S.C. Unifying theory of hypoxia tolerance: Molecular/metabolic defense and rescue mechanisms for surviving oxygen lack. Proc. Natl. Acad. Sci. USA 1996; 93(18):9493–9498.

    Article  PubMed  CAS  Google Scholar 

  • Ayus, J.C., Armstrong, D., Arieff, A.I. Hyponatremia with hypoxia: Effects on brain adaptation, perfusion, and histology in rodents. Kidney Int. 2006; 69(8):1319–1325.

    PubMed  CAS  Google Scholar 

  • Ayus, J.C., Arieff, A.I. Pulmonary complications of hyponatremic encephalopathy. Noncardiogenic pulmonary edema and hypercapnic respiratory failure. Chest 1995; 107(2):517–521.

    PubMed  CAS  Google Scholar 

  • Ayus, J.C., Varon, J., Arieff, A.I. Hyponatremia, cerebral edema, and noncardiogenic pulmonary edema in marathon runners. Ann. Intern. Med. 2000; 132(9): 711–714.

    PubMed  CAS  Google Scholar 

  • McClellan, M.D., Dauber, I.M., Weil, J.V. Elevated intracranial pressure increases pulmonary vascular permeability to protein. J. Appl. Physiol. 1989; 67(3):1185–1191.

    PubMed  CAS  Google Scholar 

  • Schrier, R.W., Gross, P., Gheorghiade, M., et al. Tolvaptan, a selective oral vasopressin V2-receptor antagonist, for hyponatremia. N. Engl. J. Med. 2006; 355(20):2099–2112.

    Article  PubMed  CAS  Google Scholar 

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Achinger, S., Ayus, J.C. (2008). Dysnatremias: Diagnosis and Treatment. In: MachasNúñez, J.F., Cameron, J.S., Oreopoulos, D.G. (eds) The Aging Kidney in Health and Disease. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-72659-5_10

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  • DOI: https://doi.org/10.1007/978-0-387-72659-5_10

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