This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Ahmad-Nejad, P., Hacker, H., Rutz, M., Bauer, S., Vabulas, R.M. and Wagner, H. (2002) Bacterial CpG-DNA and lipopolysaccharides activate Toll-like receptors at distinct cellular compartments. Eur. J. Immunol. 32, 1958-1968.
Blander, J.M. and Medzhitov, R. (2006) Toll-dependent selection of microbial antigens for presentation by dendritic cells. Nature 440, 808-812.
Bohnhorst, J., Rasmussen, T., Moen, S.H., Flottum, M., Knudsen, L., Borset, M., Espevik, T. and Sundan, A. (2006) Toll-like receptors mediate proliferation and survival of multiple myeloma cells. Leukemia 20, 1138-1144.
Bonifacino, J.S. and Traub, L.M. (2003) Signals for sorting of transmembrane proteins to endosomes and lysosomes. Annu. Rev Biochem. 72, 395-447.
Bright, N.A., Gratian, M.J. and Luzio, J.P. (2005) Endocytic delivery to lysosomes mediated by concurrent fusion and kissing events in living cells. Curr. Biol. 15, 360-365.
Chen, L.Y., Zuraw, B.L., Zhao, M., Liu, F.T., Huang, S. and Pan, Z.K. (2003) Involvement of protein tyrosine kinase in Toll-like receptor 4-mediated NF-kappa B activation in human peripheral blood monocytes. Am J Physiol Lung Cell Mol Physiol 284, L607-L613.
Choe, J., Kelker, M.S. and Wilson, I.A. (2005) Crystal structure of human toll-like receptor 3 (TLR3) ectodomain. Science 309, 581-585.
Chuang, T.H. and Ulevitch, R.J. (2004) Triad3A, an E3 ubiquitin-protein ligase regulating Toll-like receptors. Nat Immunol 5, 495-502.
Di Paolo, G. and De Camilli, P. (2006) Phosphoinositides in cell regulation and membrane dynamics. Nature 443, 651-657.
Edelson, B.T. and Unanue, E.R. (2002) MyD88-dependent but Toll-like receptor 2-independent innate immunity to Listeria: no role for either in macrophage listericidal activity. J. Immunol. 169, 3869-3875.
Feng, C.G., Scanga, C.A., Collazo-Custodio, C.M., Cheever, A.W., Hieny, S., Caspar, P. and Sher, A. (2003) Mice lacking myeloid differentiation factor 88 display profound defects in host resistance and immune responses to Mycobacterium avium infection not exhibited by Toll-like receptor 2 (TLR2)- and TLR4-deficient animals. J. Immunol. 171, 4758-4764.
Funami, K., Matsumoto, M., Oshiumi, H., Akazawa, T., Yamamoto, A. and Seya, T. (2004) The cytoplasmic ‘linker region’ in Toll-like receptor 3 controls receptor localization and signaling. Int. Immunol. 16, 1143-1154.
Gillooly, D.J., Morrow, I.C., Lindsay, M., Gould, R., Bryant, N.J., Gaullier, J.M., Parton, R.G. and Stenmark, H. (2000) Localization of phosphatidylinositol 3-phosphate in yeast and mammalian cells. EMBO J 19, 4577-4588.
Gruenberg, J. and Stenmark, H. (2004) The biogenesis of multivesicular endosomes. Nat Rev Mol Cell Biol 5, 317-323.
Gruenberg, J. and van der Goot, F.G. (2006) Mechanisms of pathogen entry through the endosomal compartments. Nat. Rev. Mol. Cell Biol. 7, 495-504.
Guha, M. and Mackman, N. (2002) The phosphatidylinositol 3-kinase-Akt pathway limits lipopolysaccharide activation of signaling pathways and expression of inflammatory mediators in human monocytic cells. J. Biol. Chem. 277, 32124-32132.
Guillot, L., Medjane, S., Le-Barillec, K., Balloy, V., Danel, C., Chignard, M. and Si-Tahar, M. (2004) Response of human pulmonary epithelial cells to lipopolysaccharide involves Toll-like receptor 4 (TLR4)-dependent signaling pathways: evidence for an intracellular compartmentalization of TLR4. J. Biol. Chem. 279, 2712-2718.
Haglund, K., Sigismund, S., Polo, S., Szymkiewicz, I., Di Fiore, P.P. and Dikic, I. (2003) Multiple monoubiquitination of RTKs is sufficient for their endocytosis and degradation. Nat. Cell Biol. 5, 461-466.
Hornef, M.W., Normark, B.H., Vandewalle, A. and Normark, S. (2003) Intracellular recognition of lipopolysaccharide by toll-like receptor 4 in intestinal epithelial cells. J. Exp. Med. 198, 1225-1235.
Huang, F., Kirkpatrick, D., Jiang, X., Gygi, S. and Sorkin, A. (2006) Differential regulation of EGF receptor internalization and degradation by multiubiquitination within the kinase domain. Mol. Cell 21, 737-748.
Husebye, H., Halaas, O., Stenmark, H., Tunheim, G., Sandanger, O., Bogen, B., Brech, A., Latz, E. and Espevik, T. (2006) Endocytic pathways regulate Toll-like receptor 4 signaling and link innate and adaptive immunity. EMBO J. 25, 683-692.
Johnsen, I.B., Nguyen, T.T., Ringdal, M., Tryggestad, A.M., Bakke, O., Lien, E., Espevik, T. and Anthonsen, M.W. (2006) Toll-like receptor 3 associates with c-Src tyrosine kinase on endosomes to initiate antiviral signaling. EMBO J. 25, 3335-3346.
Kagan, J.C. and Medzhitov, R. (2006) Phosphoinositide-mediated adaptor recruitment controls Toll-like receptor signaling. Cell 125, 943-955.
Lang, K.S., Recher, M., Junt, T., Navarini, A.A., Harris, N.L., Freigang, S., Odermatt, B., Conrad, C., Ittner, L.M., Bauer, S., Luther, S.A., Uematsu, S., Akira, S., Hengartner, H. and Zinkernagel, R.M. (2005) Toll-like receptor engagement converts T-cell autoreactivity into overt autoimmune disease. Nat. Med. 11, 138-145.
Latz, E., Schoenemeyer, A., Visintin, A., Fitzgerald, K.A., Monks, B.G., Knetter, C.F., Lien, E., Nilsen, N.J., Espevik, T. and Golenbock, D.T. (2004) TLR9 signals after translocating from the ER to CpG DNA in the lysosome. Nat. Immunol. 5, 190-198.
Latz, E., Visintin, A., Lien, E., Fitzgerald, K.A., Monks, B.G., Kurt-Jones, E.A., Golenbock, D.T. and Espevik, T. (2002) Lipopolysaccharide rapidly traffics to and from the golgi apparatus with the toll-like receptor 4-MD-2-CD14 complex in a process that is distinct from the initiation of signal transduction. J. Biol. Chem. 277, 47834-47843.
Leifer, C.A., Brooks, J.C., Hoelzer, K., Lopez, J.L., Kennedy, M.N., Mazzoni, A. and Segal, D.M. (2006) Cytoplasmic targeting motifs control localization of toll-like receptor 9. J. Biol. Chem.
Liew, F.Y., Xu, D., Brint, E.K. and O’Neill, L.A. (2005) Negative regulation of toll-like receptor-mediated immune responses. Nat. Rev. Immunol. 5, 446-458.
Marshak-Rothstein, A. (2006) Toll-like receptors in systemic autoimmune disease. Nat. Rev. Immunol. 6, 823-835.
Means, T.K., Latz, E., Hayashi, F., Murali, M.R., Golenbock, D.T. and Luster, A.D. (2005) Human lupus autoantibody-DNA complexes activate DCs through cooperation of CD32 and TLR9. J. Clin. Invest 115, 407-417.
Meusser, B., Hirsch, C., Jarosch, E. and Sommer, T. (2005) ERAD: the long road to destruction. Nat. Cell Biol. 7, 766-772.
Nilsen, N., Nonstad, U., Khan, N., Knetter, C.F., Akira, S., Sundan, A., Espevik, T. and Lien, E. (2004) Lipopolysaccharide and double-stranded RNA up-regulate toll-like receptor 2 independently of myeloid differentiation factor 88. J. Biol. Chem. 279, 39727-39735.
Nishiya, T., Kajita, E., Miwa, S. and Defranco, A.L. (2005) TLR3 and TLR7 are targeted to the same intracellular compartments by distinct regulatory elements. J. Biol. Chem. 280, 37107-37117.
Pasare, C. and Medzhitov, R. (2004) Toll-dependent control mechanisms of CD4 T cell activation. Immunity. 21, 733-741.
Rowe, D.C., McGettrick, A.F., Latz, E., Monks, B.G., Gay, N.J., Yamamoto, M., Akira, S., O’Neill, L.A., Fitzgerald, K.A. and Golenbock, D.T. (2006) The myristoylation of TRIF-related adaptor molecule is essential for Toll-like receptor 4 signal transduction. Proc. Natl. Acad. Sci. U. S. A 103, 6299-6304.
Saitoh, S., Akashi, S., Yamada, T., Tanimura, N., Matsumoto, F., Fukase, K., Kusumoto, S., Kosugi, A. and Miyake, K. (2004) Ligand-dependent Toll-like receptor 4 (TLR4)-oligomerization is directly linked with TLR4-signaling. J. Endotoxin. Res. 10, 257-260.
Sarkar, S.N., Peters, K.L., Elco, C.P., Sakamoto, S., Pal, S. and Sen, G.C. (2004) Novel roles of TLR3 tyrosine phosphorylation and PI3 kinase in double-stranded RNA signaling. Nat. Struct. Mol. Biol. 11, 1060-1067.
Schaible, U.E. and Kaufmann, S.H. (2004) Iron and microbial infection. Nat. Rev. Microbiol. 2, 946-953.
Stenmark, H., Aasland, R. and Driscoll, P.C. (2002) The phosphatidylinositol 3-phosphate-binding FYVE finger. Febs Letters 513, 77-84.
Tabeta, K., Hoebe, K., Janssen, E.M., Du, X., Georgel, P., Crozat, K., Mudd, S., Mann, N., Sovath, S., Goode, J., Shamel, L., Herskovits, A.A., Portnoy, D.A., Cooke, M., Tarantino, L.M., Wiltshire, T., Steinberg, B.E., Grinstein, S. and Beutler, B. (2006) The Unc93b1 mutation 3d disrupts exogenous antigen presentation and signaling via Toll-like receptors 3, 7 and 9. Nat. Immunol. 7, 156-164.
Thieblemont, N. and Wright, S.D. (1999) Transport of bacterial lipopolysaccharide to the golgi apparatus. J. Exp. Med. 190, 523-534.
Uematsu, S. and Akira, S. (2006) Toll-like receptors and innate immunity. J. Mol. Med.
Venkateswarlu, K., Oatey, P.B., Tavare, J.M. and Cullen, P.J. (1998) Insulin-dependent translocation of ARNO to the plasma membrane of adipocytes requires phosphatidylinositol 3-kinase. Curr. Biol. 8, 463-466.
Yarovinsky, F., Zhang, D., Andersen, J.F., Bannenberg, G.L., Serhan, C.N., Hayden, M.S., Hieny, S., Sutterwala, F.S., Flavell, R.A., Ghosh, S. and Sher, A. (2005) TLR11 activation of dendritic cells by a protozoan profilin-like protein. Science 308, 1626-1629.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2007 Springer Science+Business Media, LLC
About this paper
Cite this paper
Halaas, Ø., Husebye, H., Espevik1, T. (2007). The Journey of Toll-like Receptors in the Cell. In: Lambris, J.D. (eds) Current Topics in Innate Immunity. Advances in Experimental Medicine and Biology, vol 598. Springer, New York, NY. https://doi.org/10.1007/978-0-387-71767-8_4
Download citation
DOI: https://doi.org/10.1007/978-0-387-71767-8_4
Publisher Name: Springer, New York, NY
Print ISBN: 978-0-387-71765-4
Online ISBN: 978-0-387-71767-8
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)