Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Curnutte, J.T., Erickson, R.W., Ding, J. and Badwey, J.A. (1994) Reciprocal interactions between protein kinase C and components of the NADPH oxidase complex may regulate superoxide production by neutrophils stimulated with a phorbol ester. J. Biol. Chem. 269, 10813-10819.
Czermak, B.J., Sarma, J.V., Pierson, C.L., Warner, R.L. Huber-Lang, M.S., Bless, N.M., Schmal, H., Friedl H.P. and Ward, P.A. (1999) Protective effects of C5a blockade in sepsis. Nat. Med. 5, 788-792.
Guo, R.F., Riedemann, N.C., Bernacki, K.D., Sarma, J.V., Laudes, I.J., Reuben, J.S., Younkin, E.M., Neff, T.A., Paulauskis, J.D., Zetoune, F.S. and Ward, P.A. (2003) Neutrophil C5a receptor and the outcome in a rat model of sepsis. FASEB J. 17, 1889-1891.
Guo, R.F. and Ward, P.A. (2005) Role of C5a in inflammatory responses. Annu. Rev. Immunol. 23, 821-852.
Hopken, U.E., Lu, B., Gerard, N.P. and Gerard, C. (1997) Impaired inflammatory responses in the reverse arthus reaction through genetic deletion of the C5a receptor. J. Exp. Med. 186, 749-756.
Huber-Lang, M.S., Sarma, J.V., Lu, K.T., McGuire, S.R., Padgaonkar, V.A., Guo, R.F., Younkin, E.M., Kunkel, R.G., Ding, J., Erickson, R.E., Curnutte, J.T. and Ward, P.A. (2001) Role of C5a in multiorgan failure during sepsis. J. Immunol. 166, 1193-1199.
Huber-Lang, M.S., Younkin, E.M., Sarma, J.V., Riedemann, N., McGuire, S.R., Lu, K.T., Kunkel, R.G., Younger, J.G., Zetoune, F.S. and Ward, P.A. (2002) Generation of C5a by phagocytic cells. Am. J. Pathol. 161, 1849-1859.
Huber-Lang, M.S., Younkin, E.M., Sarma, J.V., McGuire, S.R., Lu, K.T., Guo, R.F., Padgaonkar, V.A., Curnutte, J.T., Erickson, R. and Ward, P.A. (2002) Complement induced impairment of innate immunity during sepsis. J. Immunol. 169, 3223-3231.
Huber-Lang, M.S., Sarma, J.V. McGuire, S.R., Lu, K.T., Padgaonkar, V.A., Younkin, E.M., Guo, R.F., Weber, C.H., Zuiderweg, E.R., Zetoune, F.S. and Ward, P.A. (2003) Structure-function relationships of human C5a and C5aR. J. Immunol. 170, 6115-6124.
Huber-Lang, M.S., Sarma, J.V., Rittirsch, D., Schreiber, H, Weiss, M., Flierl, M., Younkin, E, Schneider, M., Suger-Wiedeck, H., Gephard, F., McClintock, S.D., Neff, T., Zetoune, F.S., Bruckner, Guo, R.F., Monk, P.N. and Ward, P.A. (2005) Changes in the novel orphan, C5a receptor (C5L2), during experimental sepsis and sepsis in humans. J. Immunol. 174, 1104-1110.
Huber-Lang, M.S., Sarma, J.V., Zetoune, F.S., Rittirsch, D., Neff, T.A., McGuire, S.R., Lambris, J.D., Warner, R.L., Flierl, M.A., Hoesel, L.M., Gebhard, F., Younger, J.G., Drouin, S.M., Wetsel, R.A. and Ward, P.A. (2006) Generation of C5a in the absence of C3: a new complement activation pathway. Nat. Med. 12, 682-687.
Johswich, K., Martin, M., Thalmann, J., Rheinheimer, C., Monk, P.N, and Klos, A. (2006) Ligand specificity of the anaphylatoxin C5L2 receptor and its regulation on myeloid and epithelial cell-lines. http://www.jbc.org/cgi/doi/10.1074/jbc.M609734200.
Larsen, G.L., Mitchell, B.C. and Henson, P.M. (1981) The pulmonary responses of C5 sufficient and deficient mice to immune complexes. Am. Rev. Respir. Dis. 123, 434-439.
Lukacs, N.W., Glovsky, M.M. and Ward, P.A. (2001) Complement-dependent immune complex-induced bronchial inflammation and hyperreactivity. Am. J. Physiol. Lung Cell Mol. Physiol .280, L512-L518.
Maslowska, M., Legakis, H., Assadi, F.,. and Cianflone, K. (2006) Targeting the signaling pathway of acylation stimulating protein. J. Lipid Res. 47, 643-652.
Mueller-Ortiz, S.L., Drouin, S.M.,. and Wetsel, R.A. (2004) The alternative activation pathway and complement component C3 are critical for a protective immune response against Pseudomonas aeruginosa in a murine model of pneumonia. Infect. Immun. 72, 2899-2906.
Okinaga, S., Slattery, D., Humbles, A., Zsengeller, Z., Morteau, O., Kinrade, M.B., Brodbeck, R.M., Krause, J.E., Choe, H.R., Gerard, N.P. and Gerard, C. (2003) C5L2 a non-signaling C5a binding protein. Biochemistry 42, 9406-9415.
Peng, T., Hao, L., Madri, J.A., Su, X., Elias, J.A., Stahl, G.L., Squinto, S. and Wang, Y. (2005) Role of C5 in the development of airway inflammation, airway hyperresponsiveness and ongoing airway response. J. Clin. Invest. 115, 1590-1600.
Ravetch, J.V. (2002) A full complement of receptors in immune complex diseases. J. Clin. Invest. 110, 1760-1761.
Reis, E.S., Nudelman, V. and Isaac, L. (2004) Nonsense-codon-mediated decay in human hereditary complement C3 deficiency. Immunogenetics 55, 667-6673.
Riedemann, N.C., Guo, R.F., Hollmann, T.J., Gao, H., Neff, T.A., Reuben, J.S., Speyer, C.L., Sarma, J.V., Wetsel, R.A., Zetoune, F.S. and Ward, P.A. (2004) Regulatory role of C5a in LPS-induced IL-6 production by neutrophils during sepsis. FASEB J. 18, 370-372.
Schmidt, R.E. and Gessner, J.E. (2005) Fc receptors and interaction with complement in autoimmunity. Immunol. Lett. 100, 56-67.
Shushakova, N., Skokowa, J., Schulman, J., Baumann, U., Zwirner, J., Schmidt, R.E. and Gessner, J.E. (2002) C5a anaphylatoxin is a major regulator of activating versus inhibitory FcgRs in immune complex-induced lung disease. J. Clin. Invest. 110, 1823-1830.
Skokowa, J., Ali, S.R., Felda, O., Kumar, V., Konrad, S., Shushakova, N., Schmidt, R.E., Piekorz, R.P., Nurnberg, B., Spicher, K., Birnbaumer, L., Zwirner, J., Claassens, J.W.C., Verbeek, J.S., van Rooijen, N., Kohl, J. and Gessner, J.E. (2005) Macrophages induce the inflammatory response in the pulmonary arthus reaction through Gα i2 activation that controls C5aR and Fc receptor cooperation. J. Immunol. 174, 3041-3050.
Sylvestre, D., Clynes, R., Ma, M., Warren, H., Carroll, M.C. and Ravetch, J.V. (1996) Immunoglobulin G-mediated inflammatory responses develop normally in complement-deficient mice. J. Exp. Med. 184, 2385-2392.
Ward, P.A. and Hill. J.H. (1970) C5 chemotactic fragments produced by an enzyme in the lysosomal granules of neutrophils. J. Immunol. 104, 535-543.
Ward, P.A. and Zvaifler, N.J. (1973) Quantitative phagocytosis by neutrophils, II. Release of the C5 cleaving enzyme and inhibition of phagocytosis by rheumatoid factor. J. Immunol. 111, 1777-1782.
Wessels, M.R., Butko, P., Ma, M., Warren, H.B., Lage, A.L. and Carroll, M.C. (1995) Studies of group B streptococcal infection in mice deficient in complement C3 or C4 demonstrate an essential role for complement in both innate and acquired immunity. Proc. Natl. Acad. Sci. USA 92, 11490-11494.
Wetsel, R.A.,. and Kolb, W.P. (1983) Expression of C5a-like biological activities by the fifth component of human complement (C5) upon limited digestion with non complement enzymes without release of polypeptide fragments. J. Exp. Med. 157, 2029-2048.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2007 Springer Science+Business Media, LLC
About this paper
Cite this paper
Sarma, J.V., Ward, P.A. (2007). In Vivo Biological Responses in the Presence or Absence of C3. In: Lambris, J.D. (eds) Current Topics in Innate Immunity. Advances in Experimental Medicine and Biology, vol 598. Springer, New York, NY. https://doi.org/10.1007/978-0-387-71767-8_17
Download citation
DOI: https://doi.org/10.1007/978-0-387-71767-8_17
Publisher Name: Springer, New York, NY
Print ISBN: 978-0-387-71765-4
Online ISBN: 978-0-387-71767-8
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)