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Platelet-Derived Growth Factor

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Angiogenesis

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In the approximately 40 years since the initial report of the existence of PDGF we have learned a great deal regarding this family of five growth factors. We know at least something about how they initiate signaling events leading to cellular responses, and how these events contribute to biological processes essential for development, physiology and pathology. The discoveries to date indicate that we have not learned all there is to know. Additional reagents (to selectively block the action of PDGFs) and approaches (to detect PDGF-specific contributions) will profoundly accelerate future experimentation. This additional information is likely to provide new opportunities to use PDGF-based approaches to correct a wide variety of pathological afflictions including angiogenesis-dependent (solid tumors, age-related macular degeneration, diabetic complications) and proliferation-driven (atherosclerosis, solid tumors) diseases.

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Authors and Affiliations

  1. Harvard Medical School, Schepens Eye Research Institute, 02114, Boston, MA, USA

    Andrius Kazlauskas

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  1. Andrius Kazlauskas
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  1. Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA

    William D. Figg

  2. Department of Surgery Harvard Medical School and Vascular Biology Program, Children's Hospital Boston, Boston, MA, USA

    Judah Folkman

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Kazlauskas, A. (2008). Platelet-Derived Growth Factor. In: Figg, W.D., Folkman, J. (eds) Angiogenesis. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-71518-6_9

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