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Src Family Tyrosine Kinases: Implications for Mammary Tumor Progression

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Genetically Engineered Mice for Cancer Research

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Abstract

This chapter reviews the role of c-Src tyrosine kinase in mammary tumor progression. In addition to highlighting the molecular mechanism by which c-Src is activated, we explore the evidence of supporting a role for c-Src in both murine and human breast cancers. In particular, this review highlights the use of mouse models to resect the role of c-Src in mammary tumor progression. These genetic analyses provide important insight into the role of c-Src signaling pathway in oncogene-induced mammary tumor progression.

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Authors and Affiliations

  1. Ontario Cancer Institute, University of Toronto, Toronto, ON, M5G 1L7, Canada

    Richard Marcotte

  2. Goodman Cancer Center, 1160 Pine Ave., Montreal, QC, H3A 1A3, Canada

    William J. Muller

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Correspondence to William J. Muller .

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  1. , Laboratory Of Cancer Biology and Genetic, National Cancer Institute, Convent Dr. 37, Bethesda, 20892, Maryland, USA

    Jeffrey E. Green

  2. National Cancer Institute, Center for Cancer Research, National Institutes of Health, South Drive 50, Bethesda, 20892, Maryland, USA

    Thomas Ried

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Marcotte, R., Muller, W.J. (2012). Src Family Tyrosine Kinases: Implications for Mammary Tumor Progression. In: Green, J., Ried, T. (eds) Genetically Engineered Mice for Cancer Research. Springer, New York, NY. https://doi.org/10.1007/978-0-387-69805-2_16

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