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Immunotherapy of AML

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Acute Myelogenous Leukemia

Part of the book series: Cancer Treatment and Research ((CTAR,volume 145))

Abstract

The applications of chemotherapy for the treatment of AML have been unchanged over the past three decades, with only 30% of patients demonstrating disease-free survival (DFS) [118]. Despite achieving CR following induction chemotherapy, the majority of patients relapse and succumb to their disease [6]. In view of the limitations encountered by cytarabine/anthracycline based regimes, attention has shifted to immunotherapy as a means to treat AML and provide significant long-term DFS. This chapter will discuss the role of the immune system and recent advances in immunotherapy for the treatment of AML, focusing on cellular and non-cellular approaches.

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Authors and Affiliations

  1. Division of Cancer Medicine, University of Texas MD, Anderson Cancer Center, Houston, TX, USA

    Gheath Alatrash DO, PhD

  2. Division of Cancer Medicine, University of Texas MD Anderson Cancer Center, 77030, Houston, TX, USA

    Jeffrey J. Molldrem

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  1. Gheath Alatrash DO, PhD
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  1. Dept. of Genetics, MD Anderson Cancer Center, Holcombe Blvd. 1515, Houston, 77030, USA

    Lalitha Nagarajan

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Alatrash, G., Molldrem, J.J. (2009). Immunotherapy of AML. In: Nagarajan, L. (eds) Acute Myelogenous Leukemia. Cancer Treatment and Research, vol 145. Springer, New York, NY. https://doi.org/10.1007/978-0-387-69259-3_14

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