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Prostaglandin and Transforming Growth Factor β Signaling in Gastric Cancer

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The Biology of Gastric Cancers

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References

  • Akre, K., Ekstrom, A. M., Signorello, L. B., Hansson, L. E., and Nyren, O. (2001). Aspirin and risk for gastric cancer: a population-based case-control study in Sweden. Br. J. Cancer 84:965–968.

    CAS  PubMed  Google Scholar 

  • Al-Marhoon, M. S., Nunn, S., and Soames, R. W. (2004). CagA+ Helicobacter pylori induces greater levels of prostaglandin E2 than cagA–strains. Prostaglandins Other Lipid Mediat. 73:181–189.

    Google Scholar 

  • Boivin, G. P., Molina, J. R., Ormsby, I., Stemmermann, G., and Doetschman, T. (1996). Gastric lesions in transforming growth factor beta-1 heterozygous mice. Lab. Invest. 74:513–518.

    CAS  PubMed  Google Scholar 

  • Chang, J., Park, K., Bang, Y.-J., Kim, W. S., Kim, D., and Kim, S.-J. (1997). Expression of transforming growth factor β type II receptor reduced tumorigenicity in human gastric cancer cells. Cancer Res. 57:2856–2859.

    CAS  PubMed  Google Scholar 

  • Chang, Y.-J., Wu, M.-S., Lin, J.-T., and Chen, C.-C. (2005). Helicobacter pylori-induced invasion and angiogenesis of gastric cells is mediated by cyclooxygenase-2 induction through TLR2/ TLR9 and promoter regulation. J. Immunol. 175:8242–8252.

    CAS  PubMed  Google Scholar 

  • Chang, Y. J., Wu, M. S., Lin, J. T., Sheu, B. S., Muta, T., Inoue, H., and Chen,C.-C. (2004). Induction of cyclooxygenase-2 overexpression in human gastric epithelial cells by Helicobacter pylori involves TLR2/TLR9 and c-Src-dependent nuclear factor-κB activation. Mol. Pharmacol. 66:1465–1477.

    CAS  PubMed  Google Scholar 

  • Chen, C.-N., Sung, C.-T., Lin, M.-T., Lee, P.-H., and Chang, K.-J. (2001). Clinicopathologic association of cyclooxygenase 1 and cyclooxygenase 2 expression in gastric adenocarcinoma. Ann. Surg. 233:183–188.

    CAS  PubMed  Google Scholar 

  • Cheng, X.-X., Wang, Z.-C., Chen, X.-Y., Sun, Y., Kong, Q.-Y., Liu, J., and Li, H. (2005). Correlation of Wnt-2 expression and β-catenin intracellular accumulation in Chinese gastric cancers: relevance with tumour dissemination. Cancer Lett. 223:339–347.

    CAS  PubMed  Google Scholar 

  • Chi, X.-Z., Yang, J.-O., Lee, K.-Y., Ito, K., Sakakura, C., Li, Q.-L., Kim, H.-R., Cha, E.-J., Lee, Y.-H., Kaneda, A., Ushijima, T., Kim, W.-J., Ito, Y., and Bae, S.-C. (2005). RUNX3 suppresses gastric epithelial cell growth by inducing p21WAF1/CIP1 expression in cooperation with transforming growth factor β-activated SMAD. Mol. Cell. Biol. 25:8097–8107.

    CAS  PubMed  Google Scholar 

  • Chulada, P. C., Thompson, M. B., Mahler, J. F., Doyle, C. M., Gaul, B. W., Lee, C., Tiano, H. F., Morham, S. G., Smithies, O., and Langenbach, R. (2000). Genetic disruption of Ptgs-1, as well as Ptgs-2, reduces intestinal tumorigenesis in Min mice. Cancer Res. 60:4705–4708.

    CAS  PubMed  Google Scholar 

  • Clements, W. M., Wang, J., Sarnaik, A., Kim, O. J., MacDonald, J., Fenoglio-Preiser, C., Groden, J., and Lowy, A. M. (2002). β-Catenin mutation is a frequent cause of Wnt pathway activation in gastric cancer. Cancer Res. 62:3503–3506.

    CAS  PubMed  Google Scholar 

  • Correa, P. (2003). Helicobacter pylori infection and gastric cancer. Cancer Epidemiol. Biomarkers Prev. 12:238s–241s.

    PubMed  Google Scholar 

  • Derynck, R., Akhurst, R. J., and Balmain, A. (2001). TGF-β signaling in tumor suppression and cancer progression. Nat. Genet. 29:117–129.

    CAS  PubMed  Google Scholar 

  • Dewitt, D. L., and Smith, W. L. (1998). Primary structure of prostaglandin G/H synthase from sheep vesicular gland determined from the complementary DNA sequence. Proc. Natl. Acad. Sci. USA 85:1412–1416.

    Google Scholar 

  • Ebert, M. P. A., Fei, G., Kahmann, S., Müller, O., Yu, J., Sung, J. J. Y., and Malfertheiner, P. (2002). Increased β-catenin mRNA levels and mutational alterations of the APC and β-catenin gene are present in intestinal-type gastric cancer. Carcinogenesis 23:87–91.

    CAS  PubMed  Google Scholar 

  • Engle, S. J., Ormsby, I., Pawlowski, S., Boivin, G. P., Croft, J., Balish, E., and Doetschman, T. (2002). Elimination of colon cancer in germ-free transforming growth factor beta 1-deficient mice. Cancer Res. 62:6362–6366.

    CAS  PubMed  Google Scholar 

  • Fletcher, B. S., Kujubu, D. A., Perrin, D. M., and Herschman, H. R. (1992). Structure of the mitogen-inducible TIS10 gene and demonstration that the TIS10-encoded protein is a functional prostaglandin G/H synthase. J. Biol. Chem. 267:4338–4344.

    Google Scholar 

  • Fu, Y.-G., Sung, J. J. Y., Wu, K.-C., Wu, H.-P., Yu, J., Chan, M., Chan, V. Y. W., Chan, K.-K., Fan, D.-M., and Leung, W. K. (2005). Inhibition of gastric cancer-associated angiogenesis by antisense COX-2 transfectants. Cancer Lett. 224:243–252.

    CAS  PubMed  Google Scholar 

  • Futagami, S., Suzuki, K., Hiratsuka, T., Shindo,T., Hamamoto, T., Tatsuguchi, A., Ueki, N., Shinji, Y., Kusunoki, M., Wada, K., Miyake, K., Gudis, K., Tsukui,T., and Sakamoto, C. (2006). Celecoxib inhibits Cdx2 expression and prevents gastric cancer in Helicobacter pylori-infected mongolian gerbils. Digestion 74:187–198.

    CAS  PubMed  Google Scholar 

  • Gregorieff, A., and Clevers, H. (2005). Wnt signaling in the intestinal epithelium: from endoderm to cancer. Genes Dev. 19:877–890.

    CAS  PubMed  Google Scholar 

  • Gupta, R. A., and DuBois, R. N. (2001). Colorectal cancer prevention and treatment by inhibition of cyclooxygenase-2. Nat Rev. Cancer 1:11–21.

    CAS  PubMed  Google Scholar 

  • Hahm, K.-B., Lee, K. M., Kim. Y. B., Hong, W. S., Lee, W. H., Han, S. U., Kim, M. W., Ahn, B. O., Oh, T. Y., Lee, M. H., Green, J., and Kim, S. J. (2002). Conditional loss of TGF-β signaling leads to increased susceptibility to gastrointestinal carcinogenesis in mice. Aliment. Pharmacol. Ther. 16:115–127.

    CAS  PubMed  Google Scholar 

  • Han, S.-U., Kim, H.-T., Seong, D. H., Kim, Y.-S., Park, Y.-S., Bang, Y.-J., Yang, H.-K., and Kim, S.-J. (2004). Loss of the Smad3 expression increases susceptibility to tumorigenicity in human gastric cancer. Oncogene 23:1333–1341.

    CAS  PubMed  Google Scholar 

  • Hanai, J., Chen, L. F., Kanno, T., Ohtani-Fujita, N., Kim, W. Y., Guo, W.-H., Imamura, T., Ishidou, Y., Fukuchi, M., Shi, M.-J., Stavnezer, J., Kawabata, M., Miyazono, K., and Ito, Y. (1999). Interaction and functional cooperation of PEBP2/CBF with Smads. J. Biol. Chem. 44:31577–31582.

    Google Scholar 

  • Haramis, A.-P. G., Begthel, H., van den Born, M., van Es, J., Jonkheer, S., Offerhaus, G. J. A., and Clevers, H. (2004). De novo crypt formation and juvenile polyposis on BMP inhibition in mouse intestine. Science 303:1684–1686.

    CAS  PubMed  Google Scholar 

  • Hla, T., and Neilson, K. (1992). Human cylooxygenase-2 cDNA. Proc. Natl. Acad. Sci. USA 89:7384–7388.

    CAS  PubMed  Google Scholar 

  • Hohenstein, P., Molenaar, L., Elsinga, J., Morreau, H., van der Klift, H., Struijk, A., Jagmohan- Changur, S., Smits, R., van Kranen, H., van Ommen, G.-J. B., Cornelisse, C., Devilee, P., and Fodde, R. (2003). Serrated adenomas and mixed polyposis caused by a splice acceptor deletion in the mouse Smad4 gene. Genes Chromosomes Cancer 36:273–282.

    CAS  PubMed  Google Scholar 

  • Houghton, J., Stoicov, C., Nomura, S., Rogers, A. B., Carlson, J., Li, H., Cai, X., Fox, J. G., Goldenring, J. R., and Wang, T. C. (2004). Gastric cancer originating from bone marrow- derived cells. Science 306:1568–1571.

    CAS  PubMed  Google Scholar 

  • Howe, J. R., Bair, J. L., Sayed, M. G., Anderson, M. E., Mitros, F. A., Petersen, G. M., Velculescu, V. E., Traverso, G., and Vogelstein, B. (2001). Germline mutations of the gene encoding bone morphogenetic protein receptor 1A in juvenile polyposis. Nat. Genet. 28:184–187.

    CAS  PubMed  Google Scholar 

  • Hu, P. J., Yu, J., Zeng, Z. R., Leung, W. K., Lin, H. L., Tang, B. D., Bai, A. H. C., and Sung, J. J. Y. (2004). Chemoprevention of gastric cancer by celecoxib in rats. Gut 53:195–200.

    CAS  PubMed  Google Scholar 

  • Ito, Y., and Miyazono, K. (2003). RUNX transcription factors as key targets of TGF-β super- family signaling. Curr. Opin. Genet. Dev. 13:43–47.

    CAS  PubMed  Google Scholar 

  • Jang, T. J. (2004). Expression of proteins related to prostaglandin E2 biosynthesis is increased in human gastric cancer and during gastric carcinogenesis. Virchows Arch. 445:564–571.

    CAS  PubMed  Google Scholar 

  • Jenkins, B. J., Graio, D., Nheu, T., Najdovska, M., Wang, B., Waring, P., Inglese, M., McLoughlin, R. M., Jones, S. A., Topley, N., Baumann, H., Judd, L. M., Giraud, A. S., Boussioutas, A., Zhu, H.-J., and Ernst, M. (2005). Hyperactivation of Stat3 in gp130 mutant mice promotes gastric hyperproliferation and desensitizes TGF-β signaling. Nat. Med. 11:845–852.

    CAS  PubMed  Google Scholar 

  • Jin, G., Wang, L., Chen, W., Hu, Z., Zhou, Y., Tan, Y., Wang, J., Hua, Z., Ding, W., Shen, J., Zhang, Z., Wang, X., Xu, Y., and Shen, H. (2007). Variant alleles of TGFB1 and TGFBR2 are associated with a decreased risk of gastric cancer in a Chinese population. Int. J. Cancer 120:1330–1335.

    CAS  PubMed  Google Scholar 

  • Joo, Y.-E., Rew, J.-S., Seo, Y.-H., Choi, S.-K., Kim, Y.-J., Park, C.-S., and Kim, S.-J. (2003). Cyclooxygenase-2 overexpression correlates with vascular endothelial growth factor expression and tumor angiogenesis in gastric cancer. J. Clin. Gastroenterol. 37:28–33.

    CAS  PubMed  Google Scholar 

  • Kang, S. H., Bang, Y.-J., Im, Y.-H., Yang, H.-K., Lee, D. A., Lee, H. Y., Lee, H. S., Kim, N. K., and Kim, S.-J. (1999). Transcriptional repression of the transforming growth factor-β type I receptor gene by DNA methylation results in the development of TGF-β resistance in human gastric cancer. Oncogene 18:7280–7286.

    CAS  PubMed  Google Scholar 

  • Kawada, M., Seno, H., Wada, M., Suzuki, K., Kanda, N., Kayahara, T., Fukui, H., Sawada, M., Kajiyama, T., Sakai, M., and Chiba, T. (2003). Cyclooxygenase-2 expression and angiogen-esis in gastric hyperplastic polyp-association with polyp size. Digestion 67:20–24.

    CAS  PubMed  Google Scholar 

  • Kim, Y. H., Lee, H. S., Lee, H.-J., Hur, K., Kim, W. H., Bang, Y.-J., Kim, S.-J., Lee, K. U., Choe, K. J., and Yang, H.-K. (2004). Prognostic significance of the expression of Smad4 and Smad7 in human gastric carcinomas. Ann. Oncol. 15:574–580.

    CAS  PubMed  Google Scholar 

  • Kim, J. Y., Park, D. Y., Kim, G. H., Choi, K. U., Lee, C. H., Huh, G. Y., Sol, M. Y., Song, G. A., Jeon, T. Y., Kim, D. H., and Sim, M. S. (2005). Smad4 expression in gastric adenoma and adenocarcinoma: frequent loss of expression in diffuse type of gastric adenocarcinoma. Histol. Histopathol. 20:543–549.

    CAS  PubMed  Google Scholar 

  • Kim, C. J., Song, J. H., Cho, Y. G., Kim, Y. S., Kim, S. Y., Nam, S. W., Yoo, N. J., Lee, J. Y., and Park, W. S. (2007). Somatic mutations of the β-TrCP gene in gastric cancer. APMIS 115:127–133.

    CAS  PubMed  Google Scholar 

  • Kitamura, T., Kometani, K., Hashida, H., Matsunaga, A., Miyoshi, H., Hosogi, H., Aoki, M., Oshima, M., Hattori, M., Takabayashi, A., Minato, N., and Taketo, M. M. (2007). Smad4-deficient intestinal tumors recruit CCR1+ myeloid cells that promote invasion. Nat. Genet. 39:467–475.

    CAS  PubMed  Google Scholar 

  • Langman, M. J., Cheng, K. K., Gilman, E. A., and Lancashire, R. J. (2000). Effect of anti- inflammatory drugs on overall risk of common cancer: case-control study in general practice research database. BMJ 320:1642–1646.

    CAS  PubMed  Google Scholar 

  • Leung, W. K., To, K. F., Go, M. Y., Chan, K. K., Chan, F. K., Ng, E. K., Chung, S. C., and Sung, J. J. (2003). Cyclooxygenase-2 upregulates vascular endothelial growth factor expression and angiogenesis in human gastric carcinoma. Int. J. Oncol. 23:1317–1322.

    CAS  PubMed  Google Scholar 

  • Li, Q.-L., Ito, K., Sakakura, C., Fukamachi, H., Inoue, K., Chi, X.-Z., Lee, K.-Y., Nomura, S., Lee, C.-W., Han, S.-B., Kim, H.-M., Kim, W.-J., Yamamoto, H., Yamashita, N., Yano, T., Ikeda, T., Itohara, S., Inazawa, J., Abe, T., Hagiwara, T., Yamagishi, H., Ooe, A., Kaneda, A., Sugimura, T., Ushijima, T., Bae, S.-C., and Ito, Y. (2002). Causal relationship between the loss of RUNX3 expression and gastric cancer. Cell 109:113–124.

    CAS  PubMed  Google Scholar 

  • Lim, H.Y., Joo, H. J., Choi, J. H., Yi, J. W., Yang, M. S., Cho, D. Y., Kim, H. S., Nam, D. K., Lee, K. B., and Kim, H. C. (2000). Increased expression of cyclooxygenase-2 protein in human gastric carcinoma. Clin. Cancer Res. 6:519–525.

    CAS  PubMed  Google Scholar 

  • Lim, J. W., Kim, H., and Kim, K. H. (2001). Nuclear factor-kappaB regulates cyclooxygenase-2 expression and cell proliferation in human gastric cancer cells. Lab. Invest. 81:349–360.

    CAS  PubMed  Google Scholar 

  • Lin, Y., Kikuchi, S., Obata, Y., Yagyu, K., and The Tokyo Research Group on Prevention of Gastric Cancer. (2006). Serum levels of transforming growth factor β1 are significantly correlated with venous invasion in patients with gastric cancer. J. Gastroenterol. Hepatol. 21:432–437.

    CAS  PubMed  Google Scholar 

  • Liu, F., Pan, K., Zhang, X., Zhang, Y., Zhang, L., Ma, J., Dong, C., Shen, L., Li, J., Deng, D., Lin, D., and You, W. (2006). Genetic variants in cyclooxygenase-2: expression and risk of gastric cancer and its precursors in a Chinese population. Gastroenterology 130:1975–1984.

    CAS  PubMed  Google Scholar 

  • Lowy, A. M., Clements, W. M., Bishop, J., Kong, L., Bonney, T., Sisco, K., Aronow, B., Fenoglio- Preiser, C., and Groden, J. (2006). β-Catenin/Wnt signaling regulates expression of the membrane type3 matrix metalloproteinase in gastric cancer. Cancer Res. 66:4734–4741.

    CAS  PubMed  Google Scholar 

  • Magari, H., Shimizu, Y., Inada, K., Enomoto, S., Tomeki, T., Yanaoka, K., Tamai, H., Arii, K., Nakata, H., Oka, M., Utsunomiya, H., Tsutsumi, Y., Tsukamoto,T., Tatematsu, M., and Ichinose, M. (2005). Inhibitory effects of etodolac, a selective cyclooxygenase-2 inhibitor, on stomach carcinogenesis in Helicobacter pylori-infected mongolian gerbils. Biochem. Biophys. Res. Commun. 334:606–612.

    CAS  PubMed  Google Scholar 

  • Markowitz, S., Wang, J., Myeroff, L., Parsons, R., Sun, L., Lutterbaugh, J., Fan, R. S., Zborowska, E., Kinzler, K. W., Vogelstein, B., Brattain, M., and Willson, J. K. V. (1995). Inactivation of the type II TGF-beta receptor in colon cancer cells with microsatellite instability. Science 268:1336–1338.

    CAS  PubMed  Google Scholar 

  • Matsumoto,Y., Marusawa, H., Kinoshita, K., Endo, Y., Kou, T., Morisawa, T., Azuma, T., Okazaki, I.-M., Honjo, T., and Chiba, T. (2007). Helicobacter pylori infection triggers aberrant expression of activation-induced cytidine deaminase in gastric epithelium. Nat. Med. 13:470–476.

    CAS  PubMed  Google Scholar 

  • McCarthy, C. J., Crofford, L. J., Greenson, J., and Scheiman, J. M. (1999). Cyclooxygenase-2 expression in gastric antral mucosa before and after eradication of Helicobacter pylori infection. Am. J. Gastroenterol. 94:1218–1223.

    CAS  PubMed  Google Scholar 

  • Miyazawa, K., Iwaya, K., Kuroda, M., Harada, M., Serizawa, H., Koyanagi, Y., Sato, Y., Mizokami, Y., Matsuoka, T., and Mukai, K. (2000). Nuclear accumulation of beta-catenin in intestinal-type gastric carcinoma: correlation with early tumor invasion. Virchows Arch. 437:508–513.

    CAS  PubMed  Google Scholar 

  • Miyazono, K., Maeda, S., and Imamura, T. (2005). BMP receptor signaling: transcriptional targets, regulation of signals, and signaling cross-talk. Cytokine Growth Factor Rev. 16:251–263.

    CAS  PubMed  Google Scholar 

  • Mrena, J., Wiksten, J.-P., Thiel, A., Kokkola, A., Pohjola, L., Lundin, J., Nordling, S., Ristimäki, A., and Haglund, C. (2005). Cyclooxygenase-2 is an independent prognostic factor in gastric cancer and its expression is regulated by the messenger RNA stability factor HuR. Clin. Cancer Res. 11:7362–7368.

    CAS  PubMed  Google Scholar 

  • Murakami, M., Naraba, H., Tanioka, T., Semmyo, N., Nakatani, Y., Kojima, F., Ikeda, T., Fueki, M., Ueno, A., Oh-ishi, S., and Kudo, I. (2000). Regulation of prostaglandin E2 biosynthesis by induc-ible membrane-associated prostaglandin E2 synthase that acts in concert with cyclooxygenase-2. J. Biol. Chem. 275:32783–32792.

    CAS  PubMed  Google Scholar 

  • Murata, H., Kawano, S., Tsuji, S., Tsuji, M., Sawaoka, H., Kimura, Y., Shiozaki, H., and Hori, M. (1999). Cyclooxygenase-2 overexpression enhances lymphatic invasion and metastasis in human gastric carcinoma. Am. J. Gastroenterol. 94:451–455.

    CAS  PubMed  Google Scholar 

  • Myeroff, L. L., Parsons, R., Kim, S.-J., Hedrick, L., Cho, K. R., Orth, K., Mathis, M., Kinzler, K. W., Lutterbaugh, J., Park, K., Bang, Y.-J., Lee, H. Y., Park, J.-G., Lynch, H. T., Roberts, A. B., Vogelstein, B., and Markowitz, S. D. (1995). A transforming growth factor β receptor type II gene mutation common in colon and gastric but rare in endometrial cancers with microsatel- lite instability. Cancer Res. 55:5545–5547.

    CAS  PubMed  Google Scholar 

  • Nakajima, T., Maekita, T., Oda, I., Gotoda, T., Yamamoto, S., Umemura, S., Ichinose, M., Sugimura, T., Ushijima, T., and Saito, D. (2006). Higher methylation levels in gastric mucosae significantly correlate with higher risk of gastric cancers. Cancer Epidemiol. Biomarkers Prev. 15:2317–2321.

    CAS  PubMed  Google Scholar 

  • Nam, K. T., Hahm, K.-B., Oh, S.-Y., Yeo, M., Han, S.-U., Ahn, B., Kim, Y.-B., Kang, J. S., Jang, D. D., Yang, K.-H., and Kim, D.-Y. (2004). The selective cyclooxygenase-2 inhibitor nimesulide prevents Helicobacter pylori-associated gastric cancer development in a mouse model. Clin. Cancer Res. 10:8105–8113.

    CAS  PubMed  Google Scholar 

  • Nardone, G., Rocco, A., Vaira, D., Staibano, S., Budillon, A., Tatangelo, F., Sciulli, M. G., Perna, F., Salvatore, G., Di Benedetto, M., De Rosa, G., and Patrignani, P. (2004). Expression of COX-2, mPGE-synthase1, MDR-1(P-gp), and Bcl-XL: a molecular pathway of H. pylori-related gastric carcinogenesis. J. Pathol. 202:305–312.

    CAS  Google Scholar 

  • Narita, T., Saitoh, K., Kameda, T., Kuroiwa, A., Mizutani, M., Koike, C., Iba, H., and Yasugi, S. (2000). BMPs are necessary for stomach gland formation in the chicken embryo: a study using virally induced BMP-2 and Noggin expression. Development 127:981–988.

    CAS  PubMed  Google Scholar 

  • Nojima, M., Suzuki, H., Toyota, M., Watanabe, Y., Maruyama, R., Sasaki, S., Sasaki, Y., Mita, H., Nishikawa, N., Yamaguchi, K., Hirata, K., Itoh, F., Tokino, T., Mori, M., Imai, K., and Shinomura, Y. (2007). Frequent epigenetic inactivation of SFRP genes and constitutive activation of Wnt signaling in gastric cancer. Oncogene 26(32):4699–4713.

    CAS  PubMed  Google Scholar 

  • Nomura, S., Baxter, T., Yamaguchi, H., Leys, C., Vartapetian, A. B., Fox, J. G., Lee, J. R., Wang, T. C., and Goldenring, J. R. (2004). Spasmolytic polypeptide expressing metaplasia to preneo-plasia in H. felis-infected mice. Gastroenterology 127:582–594.

    CAS  Google Scholar 

  • Offerhaus, G. J., Giardiello, F. M., Krush, A. J., Booker, S. V., Tersmette, A. C., Kelley, N. C., and Hamilton, S. R. (1992). The risk of upper gastrointestinal cancer in familial adenomatous polyposis. Gastroenterology 102:1980–1982.

    CAS  PubMed  Google Scholar 

  • Ohno, R., Yoshinaga, K., Fujita, T., Hasegawa, K., Iseki, H., Tsunozaki, H., Ichikawa, W., Nihei, Z., and Sugihara, K. (2001). Depth of invasion parallels increased cyclooxygenase-2 levels in patients with gastric carcinoma. Cancer 91:1876–1881.

    CAS  PubMed  Google Scholar 

  • Oshima, M., Dinchuk, J. E., Kargman, S. L., Oshima, H., Hancock, B., Kwong, E., Trzaskos, J. M., Evans, J. F., and Taketo, M. M. (1996). Suppression of intestinal polyposis in ApcΔ716 knockout mice by inhibition of cyclooxygenase 2 (COX-2). Cell 87:803–809.

    CAS  PubMed  Google Scholar 

  • Oshima, H., Matsunaga, A., Fujimura, T., Tsukamoto, T., Taketo, M. M. and Oshima, M. (2006). Carcinogenesis in mouse stomach by simultaneous activation of the Wnt signaling and pros-taglandin E2 pathway. Gastroenterology 131:1086–1095.

    CAS  PubMed  Google Scholar 

  • Oshima, H., Oshima, M., Inaba, K., and Taketo, M. M. (2004). Hyperplastic gastric tumors induced by activated macrophages in COX-2 /mPGES-1 transgenic mice. EMBO J. 23:1669–1678.

    CAS  PubMed  Google Scholar 

  • Oshima, M., Oshima, H., Kitagawa, K., Kobayashi, M., Itakura, C., and Taketo M. (1995). Loss of Apc heterozygosity and abnormal tissue building in nascent intestinal polyps in mice carrying a truncated Apc gene. Proc. Natl. Acad. Sci. USA 92:4482–4486.

    CAS  PubMed  Google Scholar 

  • Oshima, H., Oshima, M., Kobayashi, M., Tsutsumi, M., and Taketo, M. M. (1997). Morphological and molecular processes of polyp formation in ApcΔ716 knockout mice. Cancer Res. 57:1644–1649.

    CAS  PubMed  Google Scholar 

  • Oshima, M., Oshima, H., Matsunaga, A., and Taketo, M. M. (2005). Hyperplastic gastric tumors with spasmolytic polypeptide-expressing metaplasia caused by tumor necrosis factor-α-dependent inflammation in cyclooxygenase-2/microsomal prostaglandin E synthase-1 trans- genic mice. Cancer Res. 65:9147–9151.

    CAS  PubMed  Google Scholar 

  • Oshima, M., and Taketo, M. M. (2002). COX selectivity and animal models for colon cancer. Curr. Pharm. Des. 8:1021–1034.

    CAS  PubMed  Google Scholar 

  • Pai, R., Soreghan, B., Szabo, I. L., Pavelka, M., Baatar, D., and Tarnawski, A. S. (2002). Prostaglandin E2 transactivates EGF receptor: a novel mechanism for promoting colon cancer growth and gastrointestinal hypertrophy. Nat. Med. 8:289–293.

    CAS  PubMed  Google Scholar 

  • Park, K., Kim, S.-J., Bang, Y.-J., Park, J.-G., Kim, N. K., Roberts, A, B., and Sporn, M. B. (1994). Genetic changes in the transforming growth factor β (TGF-β) type II receptor gene in human gastric cancer cells: correlation with sensitivity to growth inhibition by TGF-β. Proc. Natl. Acad. Sci. USA 91:8772–8776.

    CAS  PubMed  Google Scholar 

  • Park, W. S., Oh, R. R., Park, J. Y., Lee, S. H., Shin, M. S., Kim, Y. S., Kim, S. Y., Lee, H. K., Kim, P. J., Oh, S. T., Yoo, N, J., and Lee, J. Y. (1999). Frequent somatic mutations of the β-catenin gene in intestinal-type gastric cancer. Cancer Res. 59:4257–4260.

    CAS  PubMed  Google Scholar 

  • Parsons, R., Myeroff, L. L., Liu, B., Willson, J. K. V., Markowitz, S. D., and Kinzler, K. W. (1995). Microsatellite instability and mutations of the transforming growth factor β type II receptor gene in colorectal cancer. Cancer Res. 55:5548–5550.

    CAS  PubMed  Google Scholar 

  • Pinto, M., Oliveira, C., Cirnes, L., Machado, J. C., Ramires, M., Nogueira, A., Carneiro, F., and Seruca, R. (2003). Promoter methylation of TGFβ receptor I and mutation of TGFβ receptor II are frequent events in MSI sporadic gastric carcinomas. J. Pathol. 200:32–38.

    CAS  PubMed  Google Scholar 

  • Ristimäki, A., Honkanen, N., Jänkälä, H., Sipponen, P., and Härkönen, M. (1997). Expression of cyclooxygenase-2 in human gastric carcinoma. Cancer Res. 57:1276–1280.

    PubMed  Google Scholar 

  • Saito, H., Tsujitani, S., Oka, S., Kondo, A., Ikeguchi, M., Maeta, M., and Kaibara, N. (1999). The expression of transforming growth factor-β1 is significantly correlated with the expression of vascular endothelial growth factor and poor prognosis of patients with advanced gastric carcinoma. Cancer 86:1455–1462.

    CAS  PubMed  Google Scholar 

  • Sakakura, C., Hasegawa, K., Miyagawa, K., Nakashima, S., Yoshikawa, T., Kin, S., Nakase, Y., Yazumi, S., Yamagishi, H., Okanoue, T., Chiba, T., and Hagiwara, A. (2005). Possible involvement of RUNX3 silencing in the peritoneal metastases of gastric cancers. Clin. Cancer Res. 11:6479–6488.

    CAS  PubMed  Google Scholar 

  • Saukkonen, K., Nieminen, O., van Rees, B., Vilkki, S., Härkönen, M., Juhola, M., Mecklin, J.-P., Sipponen, P., and Ristimäki, A. (2001). Expression of cyclooxygenase-2 in dysplasia of the stomach and in intestinal-type gastric adenocarcinoma. Clin. Cancer Res. 7:1923–1931.

    CAS  PubMed  Google Scholar 

  • Saukkonen, K., Rintahaka, J., Sivula, A., Buskens, C. J., van Rees, B. P., Rio, M.-C., Haglund, C., van Lanschot, J. J. B., Offerhaus, G. J. A., and Ristimäki, A. (2003). Cyclooxygenase-2 and gastric carcinogenesis. APMIS 111:915–925.

    Google Scholar 

  • Sawaoka, H., Kawano, S., Tsuji, S., Tsujii, M., Gunawan, E. S., Takei, Y., Nagano, K., and Hori, M. (1998). Cyclooxygenase-2 inhibitors suppress the growth of gastric cancer xenografts via induction of apoptosis in nude mice. Am. J. Physiol. 274:G1061–1067.

    CAS  PubMed  Google Scholar 

  • Schreinemachers, D. M., and Everson, R. B. (1994). Aspirin use and lung, colon, and breast cancer incidence in a prospective study. Epidemiology 5:138–146.

    CAS  Google Scholar 

  • Seno, H., Oshima, M., Ishikawa, T., Oshima, H., Takaku, K., Chiba, T., Narumiya, S., and Taketo, M. M. (2002). Cyclooxygeanse-2 and prostaglandin E2 receptor EP2-dependent angiogenesis in ApcΔ716 mouse intestinal polyps. Cancer Res. 62:506–511.

    CAS  PubMed  Google Scholar 

  • Shao, J., Sheng, H., Aramandla, R., Pereira, M. A., Lubet, R. A., Hawk, E., Grogan, L., Kirsch, I. R., Washington, M. K., Beauchamp, R. D., and DuBois, R. N. (1999). Coordinate regulation of cyclooxygenase-2 and TGF-β1 in replication error-positive colon cancer and azoxymethane-induced rat colonic tumors. Carcinogenesis 20:185–191.

    CAS  PubMed  Google Scholar 

  • Shen, H., Sun, W.-H., Xue, Q.-P., Wu, J., Cheng, Y.-L., Ding, G.-X., Fu, H.-Y., Tsuji, S., and Kawano, S. (2006). Influences of Helicobacter pylori on cyclooxygenase-2 expression and prostaglandinE2 synthesis in rat gastric epithelial cells in vitro. J. Gastroenterol. Hepatol. 21:754–758.

    PubMed  Google Scholar 

  • Sheng, H., Shao, J., Dixon, D. A., Williams, C. S., Prescott, S. M., DuBois, R. N., and Beauchamp, R. D. (2000). Transforming growth factor-β1 enhances Ha-ras-induced expression of cycloox-ygenase-2 in intestinal epithelial cells via stabilization of mRNA. J. Biol. Chem. 275:6628–6635.

    CAS  PubMed  Google Scholar 

  • Shi, Y., and Massagué, J. (2003). Mechanisms of TGF-β signaling from cell membrane to the nucleus. Cell 113:685–700.

    CAS  PubMed  Google Scholar 

  • Shi, H., Xu, J.-M., Hu, N.-Z., and Xie, H.-J. (2003). Prognostic significance of expression of cyclooxygenase-2 and vascular endothelial growth factor in human gastric carcinoma. World J. Gastroenterol. 9:1421–1426.

    CAS  PubMed  Google Scholar 

  • Shull, M. M., Ormsby, I., Kier, A. B., Pawlowski, S., Diebold, R. J., Yin, M., Allen, R., Sidman, C, Proetzel, G., Calvin, D., Annunziata, N., and Doetschman, T. (1992). Targeted disruption of the mouse transforming growth factor-β1 gene results in multifocal inflammatory disease. Nature 359:693–699.

    CAS  PubMed  Google Scholar 

  • Smith, M. F., Jr., Mitchell, A., Li, G., Ding, S., Fitzmaurice, A. M., Ryan, K., Crowe, S., and Goldberg, J. B. (2003). Toll-like receptor (TLR) 2 and TLR5, but not TLR4, are required for Helicobacter pylori-induced NF-kB activation and chemokine expression by epithelial cells. J. Biol. Chem. 278:32552–32560.

    CAS  PubMed  Google Scholar 

  • Sonoshita, M., Takaku, K., Sasaki, N., Sugimoto, Y., Ushikubi, F, Narumiya, S., Oshima, M., and Taketo, M. M. (2001). Acceleration of intestinal polyposis through prostaglandin receptor EP2 in ApcΔ716 knockout mice. Nat. Med. 7:1048–1051.

    CAS  PubMed  Google Scholar 

  • Stichtenoth, D. O., Thorén, S., Bian, H., Peters-Golden, M., Jakobsson, P.-J., and Crofford, L. J. (2001). Microsomal prostaglandin E synthase is regulated by proinflammatory cytokines and glucocorticoids in primary rheumatoid synovial cells. J. Immunol. 167:469–474.

    CAS  PubMed  Google Scholar 

  • Sun, W.-H., Yu, Q., Shen, H., Ou, X.-L., Cao, D.-Z., Yu, T, Qian, C, Zhu, F, Sun, Y.-L., Fu, X.-L., and Su, H. (2004). Roles of Helicobacter pylori infection and cyclooxygenase-2 expression in gastric carcinogenesis. World J. Gastroenterol. 10:2809–2813.

    CAS  PubMed  Google Scholar 

  • Sung, J. J. Y, Leung, W. K., Go, M. Y Y, To, K. F, Cheng, A. S. L., Ng, E. K. W., and Chan, F K. L. (2000). Cyclooxygenase-2 expression in Helicobacter pylori-associated premalignant and malignant gastric lesions. Am. J. Pathol. 157:729–735.

    CAS  PubMed  Google Scholar 

  • Takaku, K., Miyoshi, H., Matsunaga, A., Oshima, M., Sasaki, N., and Taketo, M. M. (1999). Gastric and duodenal polyps in Smad4 (Dpc4) knockout mice. Cancer Res. 59:6113–6117.

    CAS  PubMed  Google Scholar 

  • Taketo, M. M. (2006). Wnt signaling and gastrointestinal tumorigenesis in mouse models. Oncogene 25:7522–7530.

    CAS  PubMed  Google Scholar 

  • Takeda, H., Miyoshi, H., Tamai, Y, Oshima, M., and Taketo, M. M. (2004). Simultaneous expression of COX-2 and mPGES-1 in mouse gastrointestinal hamartomas. Br. J. Cancer 90:701–704.

    CAS  PubMed  Google Scholar 

  • Tang, C, Liu, C, Zhou, X., and Wang, C. (2004). Enhanced inhibitive effects of combination of rofecoxib and octreotide on the growth of human gastric cancer. Int. J. Cancer 112:470–474.

    CAS  PubMed  Google Scholar 

  • Tatsuguchi, A., Matsui, K., Shinji, Y, Gudis, K., Tsukui, T, Kishida, T, Fukuda, Y, Sugisaki, Y, Tokunaga, A., Tajiri, T, and Sakamoto, C. (2004). Cyclooxygenase-2 expression correlates with angiogenesis and apoptosis in gastric cancer tissue. Hum. Pathol. 35:488–495.

    CAS  PubMed  Google Scholar 

  • Tebbutt, N. C, Giraud, A. S., Inglese, M., Jenkins, B., Waring, P., Clay, F J., Malki, S., Alderman, B. M., Grail, D., Hollande, F, Heath, J. K., and Ernst, M. (2002). Reciprocal regulation of gastrointestinal homeostasis by SHP2 and STAT-mediated trefoil gene activation in gp130 mutant mice. Nat. Med. 8:1089–1097.

    CAS  PubMed  Google Scholar 

  • Thiel, A., Heinonen, M., Rintahaka, J., Hallikainen, T, Hemmes, A., Dixon, D. A., Haglund, C, and Ristimäki, A. (2006). Expression of cyclooxygenase-2 is regulated by glycogen synthase kinase-3|3 in gastric cancer cells. J. Biol. Chem. 281:4564–4569.

    CAS  PubMed  Google Scholar 

  • Thun, M. J., Namboodiri, M. M., Calle, E. E., Flanders, W D., and Heath, C. W, Jr. (1993). Aspirin use and risk of fatal cancer. Cancer Res. 53:1322–1327.

    CAS  PubMed  Google Scholar 

  • Thun, M. J., Namboodiri, M. M., and Heath, C. W, Jr. (1991). Aspirin use and reduced risk of fatal colon cancer. N. Engl. J. Med. 325:1593–1596.

    CAS  PubMed  Google Scholar 

  • Tsujii, M., and DuBois, R. N. (1995). Alterations in cellular adhesion and apoptosis in epithelial cells overexpressing prostaglandin endoperoxide synthase 2. Cell 83:493–501.

    CAS  PubMed  Google Scholar 

  • Tsujii, M., Kawano, S., Tsuji, S., Sawaoka, H., Hori, M., and DuBois, R. N. (1998). Cyclooxygenase regulates angiogenesis induced colon cancer cells. Cell 93:705–716.

    CAS  PubMed  Google Scholar 

  • Uefuji, K., Ichikura, T, and Mochizuki, H. (2000). Cyclooxygenase-2 expression is related to prostaglandin biosynthesis and angiogenesis in human gastric cancer. Clin. Cancer Res. 6:135–138.

    CAS  PubMed  Google Scholar 

  • van Rees, B. P., Saukkonen, K., Ristimäki, A., Polkowski, W, Tytgat, G. N. J., Drillenburg, P., and Offerhaus, G. J. A. (2002). Cyclooxygenase-2 expression during carcinogenesis in the human stomach. J. Pathol. 196:171–179.

    PubMed  Google Scholar 

  • van Rees, B. P., Sivula, A., Thorén, S., Yokozaki, H., Jakobsson, P.-J., Offerhaus, J. A., and Ristimäki, A. (2003). Expression of microsomal prostaglandin E synthase-1 in intestinal type gastric adenocarcinoma and in gastric cancer cell lines. Int. J. Cancer 107:551–556.

    CAS  Google Scholar 

  • Wen, X.-Z., Akiyama, Y., Baylin, S., and Yuasa, Y. (2006). Frequent epigenetic silencing of the bone morphogenetic protein 2 gene through methylation in gastric carcinomas. Oncogene 25:2666–2673.

    CAS  PubMed  Google Scholar 

  • Wen, X.-Z., Miyake, S., Akiyama, Y., and Yuasa, Y. (2004). BMP-2 modulates the proliferation and differentiation of normal and cancerous gastric cells. Biochem. Biophys. Res. Commun. 316:100–106.

    CAS  PubMed  Google Scholar 

  • Woo, D. K., Kim, H. S., Lee, H. S., Kang, Y. H., Yang, H. K., and Kim, W. H. (2001). Altered expression and mutation of β-catenin gene in gastric carcinomas and cell lines. Int. J. Cancer 95:108–113.

    CAS  PubMed  Google Scholar 

  • Wu, Y.-L., Fu, S.-L., Zhang, Y.-P., Qiao, M.-M., and Chen, Y. (2005). Cyclooxygenase-2 inhibitors suppress angiogenesis and growth of gastric cancer xenografts. Biomed. Pharmacother. 59:S289–S292.

    CAS  PubMed  Google Scholar 

  • Xiangming, C., Natsugoe, S., Takao, S., Hokita, S., Ishigami, S., Tanabe, G., Baba, M., Kuroshima, K., and Aikou, T. (2001). Preserved Smad4 expression in the transforming growth factor β signaling pathway is a favorable prognostic factor in patients with advanced gastric cancer. Clin. Cancer Res. 7:277–282.

    CAS  PubMed  Google Scholar 

  • Xiao, F., Furuta, T., Takashima, M., Shirai, N., and Hanai, H. (2001). Involvement of cyclooxy-genase-2 in hyperplastic gastritis induced by Helicobacter pylori infection in C57BL/6 mice. Aliment. Pharmacol. Ther. 15:875–886.

    CAS  PubMed  Google Scholar 

  • Xie, W. L., Chipman, J. G., Robertson, D. L., Erikson, R. L., and Simmons, D. L. (1991). Expression of a mitogen-responsive gene encoding prostaglandin synthase is regulated by mRNA splicing. Proc. Natl. Acad. Sci. USA 88:2692–2696.

    CAS  PubMed  Google Scholar 

  • Xu, X., Brodie, S. G., Yang, X., Im, Y.-H., Parks, W. T., Chen, L., Zhou, Y.-X., Weinstein, M., Kim, S.-J., and Deng, C.-X. (2000). Haploid loss of the tumor suppressor Smad4/Dpc4 initiates gastric polyposis and cancer in mice. Oncogene 19:1868–1874.

    CAS  PubMed  Google Scholar 

  • Yamagata, R., Shimoyama, T., Fukuda, S., Yoshimura, T., Tanaka, M., and Munakata, A. (2002). Cyclooxygenase-2 expression is increased in early intestinal-type gastric cancer and gastric mucosa with intestinal metaplasia. Eur. J. Gastroenterol. Hepatol. 14:359–363.

    CAS  PubMed  Google Scholar 

  • Yang, H.-K., Kang, S. H., Kim, Y.-S., Won, K., Bang, Y.-J., and Kim. S.-J. (1999). Truncation of the TGF-β type II receptor gene results in insensitivity to TGF-β in human gastric cancer cells. Oncogene 18:2213–2219.

    CAS  PubMed  Google Scholar 

  • Yano, T., Ito, K., Fukamachi, H., Chi, X.-Z., Wee, H.-J., Inoue, K., Ida, H., Bouillet, P., Strasser, A., Bae, S.-C., and Ito, Y. (2006). The RUNX3 tumor suppressor upregulates Bim in gastric epithelial cells undergoing transforming growth factor β-induced apoptosis. Mol. Cell. Biol. 26:4474–4488.

    CAS  PubMed  Google Scholar 

  • Yoshimatsu, K., Golijanin, D., Paty, P. B., Soslow, R. A., Jakobsson, P.-J., DeLellis, R. A., Subbaramaiah, K., and Dannenberg, A. J. (2001). Inducible microsomal prostaglandin E syn-thase is overexpressed in colorectal adenomas and cancer. Clin. Cancer Res. 7:3971–3976.

    CAS  PubMed  Google Scholar 

  • Yu, H.-G., Li, J.-Y., Yang, Y.-N., Luo, H.-S., Yu, J.-P., Meier, J. J., Schrader, H., Bastian, A., Schmidt, W. E., and Schmitz, F. (2003). Increased abundance of cyclooxygenase-2 correlates with vascular endothelial growth factor-A abundance and tumor angiogenesis in gastric cancer. Cancer Lett. 195:43–51.

    CAS  PubMed  Google Scholar 

  • Zaridze, D., Borisova, E., Maximovitch, D., and Chkhikvadze, V. (1999). Aspirin protects against gastric cancer: results of a case-control study from Moscow, Russia. Int. J. Cancer 82:473–476.

    CAS  PubMed  Google Scholar 

  • Zhou, Y., Ran, J., Tang, C., Wu, J., Honghua, L., Xingwen, L., Ning, C., and Qiao, L. (2007). Effect of celecoxib on E-cadherin, VEGF, microvessel density and apoptosis in gastric cancer. Cancer Biol. Ther. 6:269–275.

    PubMed  Google Scholar 

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Authors and Affiliations

  1. Division of Genetics, Cancer Research Institute, Kanazawa University, Japan

    Masanobu Oshima & Hiroko Oshima

  2. Department of Pharmacology, Kyoto University Graduate School of Medicine, Japan

    Makoto Mark Taketo

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  1. Masanobu Oshima
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  1. Division of Digestive and Liver Diseases, Columbia University, New York, NY, USA

    Timothy C. Wang (Silberberg Professor of Medicine Chair) (Silberberg Professor of Medicine Chair)

  2. Division of Comparative Medicine, Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA

    James G. Fox (Director, Professor) (Director, Professor)

  3. Immunity and Environment Murdoch Childrens Research Institute, Royal Melbourne Hospital Footscray, Melbourne, Australia

    Andrew S. Giraud (Professor and Research Theme Director Infection) (Professor and Research Theme Director Infection)

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Oshima, M., Oshima, H., Taketo, M.M. (2009). Prostaglandin and Transforming Growth Factor β Signaling in Gastric Cancer. In: Wang, T.C., Fox, J.G., Giraud, A.S. (eds) The Biology of Gastric Cancers. Springer, New York, NY. https://doi.org/10.1007/978-0-387-69182-4_20

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