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Coregulators and the Regulation of Androgen Receptor Action in Prostate Cancer

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Androgen Action in Prostate Cancer

Abstract

The importance of androgen receptors in primary prostate cancer is well established and some form of androgen blockade is the primary treatment for metastatic prostate cancer. There is increasing evidence that the androgen receptor (AR) continues to play a role in castration resistant disease despite the decrease in serum androgens. Thus, factors that modulate AR activity are potential therapeutic targets. AR is a transcription factor that regulates its target genes by recruiting a complex of coregulators with multiple enzymatic activities. These coregulators remodel chromatin, modify receptor, other coregulators, and general transcription factors, as well as affect splicing decisions. Here we summarize current evidence for changes in expression of coregulators in prostate cancer and their function in prostate cancer cell lines. Many of these coregulators have pleiotropic functions and modulate transcription factors other then AR. Thus, they may have both AR dependent and AR independent roles in prostate cancer.

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  1. Baylor College of Medicine, Houston, TX, USA

    Nancy L. Weigel

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  1. Irina U. Agoulnik
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Correspondence to Nancy L. Weigel .

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James Mohler Donald Tindall

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Agoulnik, I.U., Weigel, N.L. (2009). Coregulators and the Regulation of Androgen Receptor Action in Prostate Cancer. In: Mohler, J., Tindall, D. (eds) Androgen Action in Prostate Cancer. Springer, New York, NY. https://doi.org/10.1007/978-0-387-69179-4_14

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