Abstract
Obstructive sleep apnea (OSA) is a highly prevalent sleep disorder, characterized by repeated disruptions of breathing during sleep. The sleep fragmentation and the accompanying hypoxemia lead to many negative consequences including cardiovascular diseases, cognitive impairment, daytime sleepiness, fatigue, and depressive symptoms (Parish and Somers 2004; Reimer and Flemons 2003). Originally viewed as an interesting but rare malady, OSA is now recognized as a common disorder that is associated with major morbidity and mortality (Newman et al. 2001).
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References
Bardwell, W.A., Ancoli-Israel S., and Dimsdale J. (2001) Types of coping strategies are associated with increased depressive symptoms in patients with obstructive sleep apnea. Sleep 24, 905–909.
Bardwell, W.A., Moore, P., Ancoli-Israel, S., and Dimsdale J. (2003) Fatigue in obstructive sleep apnea: Driven by depressive symptoms instead of apnea severity? Am J Psychiatry 160, 350–355.
Bernstein, D., Doshi, R., Huang, S., Strandness, E., and Jasper, J. R. (1992) Transcriptional regulation of left ventricular beta-adrenergic receptors during chronic hypoxia. Circ Res 71, 1465–1471.
Borovikova, L.V., Ivanova, S., Ivanova, M., Yang, H., Botchkina, G., Watkins, L.R., Wang, H., Abumrad, N., Eaton, J.W., and Tracey, K.J. (2000) Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin. Nature 405, 458–462.
Brodde, O.E., Michel, M., Gordon, E.P., Sandoval, A., Gilbert, E.M., and Bristow, M.R. (1989) Beta-adrenoceptor regulation in the human heart: Can it be monitored in circulating lymphocytes? Eur Heart J 10, SB2–SB10.
Carlson, J.T., Hedner, J., Elam, M., Ejnell, H., Sellgren, J., and Wallin, B.G. (1993) Augmented resting sympathetic activity in awake patients with obstructive sleep apnea. Chest 103, 1763–1768.
Dimsdale, J., Coy, T., Ziegler, M.G., Ancoli-Israel, S., and Clausen, J. (1995) The effect of sleep apnea on plasma and urinary catecholamines. Sleep 18, 377–381.
Dimsdale, J.E., Coy, T., Ancoli-Israel, S., Mills, P.J., Clausen, J., and Ziegler, M. (1997) Sympathetic nervous system alterations in sleep apnea. The relative importance of respiratory disturbance, hypoxia, and sleep quality. Chest 111, 639–642
Eisensehr, I., Ehrenberg, B., Noachtar, S., Korbett, K., Byrne, A., McAuley, A., and Palabrica, T. (1998) Platelet activation, epinephrine, and blood pressure in obstructive sleep apnea syndrome. Neurology 51, 188–195.
Entzian, P., Linnemann, K., Schlaak, M., and Zabel, P. (1996) Obstructive sleep apnea syndrome and circadian rhythms of hormones and cytokines. Am J Respir Crit Care Med 153, 1080–1086.
Fletcher, E.C. (2003) Sympathetic over activity in the etiology of hypertension of obstructive sleep apnea. Sleep 26, 15–19.
Hartmann, G., Tschop, M., Fischer, R., Bidlingmaier, C., Riepl, R., Tschop, K., Hautmann, H., Endres, S., and Toepfer, M. (2000) High altitude increases circulating interleukin-6, interleukin-1 receptor antagonist and C-reactive protein. Cytokine 12, 246–252.
Irwin, M. (2001) Neuroimmunology of disordered sleep in depression and alcoholism. Neuropsychopharmacology 5, S45–S49.
Kelley, K.W., Bluthe, R.M., Dantzer, R., Zhou, J.H., Shen, W.H., Johnson, R.W., and Broussard, S.R. (2003) Cytokine-induced sickness behavior. Brain Behav Immun S1, S112–S118.
Kennedy, B., and Ziegler, M.G. (1990) A more sensitive and specific radioenzymatic assay for catecholamines. Life Sci 47, 2143–2153.
Kobayashi, K., Nishimura, Y., Shimada, T., Yoshimura, S., Funada, Y., Satouchi, M., and Yokohama, M. (2006) Effect of continuous positive airway pressure on soluble CD40 ligand in patients with obstructive sleep apnea syndrome. Chest 129, 632–637.
Krueger, J.M., Obal, F.J., Fang, J., Kubota, T., and Taishi, P. (2001) The role of cytokines in physiological sleep regulation. Ann N Y Acad Sci 933, 211–221.
Landsberg, R., Friedman, M., and Ascher-Landsberg, J. (2001) Treatment of hypoxemia in obstructive sleep apnea. Am J Rhinol 15, 311–313.
Leuenberger, U.A., Brubaker, D., Quraishi, S., Hogeman, C., Imadojemu, V.A., and Gray, K.S. (2005) Effects of intermittent hypoxia on sympathetic activity and blood pressure in humans. Auton Neurosci 121, 87–93.
Marsh, J.D., and Sweeney, K.A. (1989) Beta-adrenergic receptor regulation during hypoxia in intact cultured heart cells. Am J Physiol 256, H275–H281.
Mills, P.J., Dimsdale, J., Coy, T., Ancoli-Israel, S., and Clausen, J. (1995) β2-Adrenergic receptor characteristics in sleep apnea patients. Sleep 18, 39–42.
Mills, P.J., Dimsdale, J.E., Ancoli-Israel, S., Clausen, J., and Loredo, J. (1998) The effects of hypoxia and sleep apnea on isoproterenol sensitivity. Sleep 21, 731–735.
Mills, P.J., Kennedy, B.P., Loredo, J., Dimsdale, J.E., and Ziegler, M.G. (2006) Effects of nasal continuous positive airway pressure and oxygen on norepinephrine kinetics and cardiovascular responses in obstructive sleep apnea. J Appl Physiol 100, 343–348.
Minoguchi, K., Tazaki, T., Yokoe, T., Minoguchi, H., Watanabe, Y., Yamamoto, M., and Adachi, M. (2004) Elevated production of tumor necrosis factor-alpha by monocytes in patients with obstructive sleep apnea syndrome. Chest 2004 126, 1473–1479.
Nelesen, R.A., Yu, H., Ziegler, M.G., Mills, P.J., Clausen, J.L., and Dimsdale, J.E (2001). Continuous positive airway pressure normalizes cardiac autonomic and hemodynamic responses to a laboratory stressor in apneic patients. Chest 119, 1092–1101.
Nelesen, R.A., Dimsdale, J., Mills, P.J., Clausen, J., Ziegler, M.G., and Ancoli-Israel, S. (1996) Altered cardiac contractility in sleep apnea. Sleep 19, 139–144.
Newman, A.B., Nieto, F.J., Guidry, U., Lind, B.K., Redline, S., Pickering, T.G., and Quan, S.F. (2001) Sleep Heart Health Study Research Group. Relation of sleep-disordered breathing to cardiovascular disease risk factors: The Sleep Heart Health Study. Am J Epidemiol 154, 50–59.
Norman, D., Loredo, J., Nelesen, R., Ancoli-Israel, S., Mills, P.J., Ziegler, M.G., and Dimsdale, J.E. (2006). Effects of continuous positive airway pressure versus supplemental oxygen on 24-hour ambulatory blood pressure. Hypertension 47, 840–845.
Opp, M.R. (1995) Corticotropin-releasing hormone involvement in stressor-induced alterations in sleep and in the regulation of waking. Adv Neuroimmunol 5, 127–143.
Opp, M.R. (2002) Cytokines and sleep promotion: A potential mechanism for disorders of excessive daytime sleepiness. In: A. Pack (Ed.), Pathogenesis, Diagnosis and Treatment of Sleep Apnea. Marcel Dekker, New York, pp. 327–351.
Parish, J.M., and Somers, V.K. (2004) Obstructive sleep apnea and cardiovascular disease. Mayo Clin Proc 79, 1036–1046.
Phillips, B.A., Schmitt, F., Berry, D.T., Lamb, D.G., Amin, M., and Cook, Y.R. (1990) Treatment of obstructive sleep apnea. A preliminary report comparing nasal CPAP to nasal oxygen in patients with mild OSA. Chest 98, 325–330.
Reimer, M.A., and Flemons, W.W. (2003) Quality of life in sleep disorders. Sleep Med Rev 7, 335–349.
Ridker, P.M., Hennekens, C.H., Roitman-Johnson, B., Stampfer, M.J., and Allen, J. (1998) Plasma concentration of soluble intercellular adhesion molecule 1 and risks of future myocardial infarction in apparently healthy men. Lancet 351, 88–92.
Robinson, G.V., Stradling, J.R., and Davies, R. (2004) Obstructive sleep apnoea/hypopnoea syndrome and hypertension. Thorax 59, 1089–1094.
Vgontzas, A.N., Papanicolaou, D.A., Bixler, E.O., Kales, A., Tyson, K., and Chrousos, G.P. (1997) Elevation of plasma cytokines in disorders of excessive daytime sleepiness: Role of sleep disturbance and obesity. J Clin Endocrinol Metab 82, 1313–1316.
Vgontzas, A.N., Papanicolaou, D.A., Bixler, E.O., Hopper, K., Lotsikas, A., Lin, H.M., Kales, A., and Chrousos, G.P. (2000) Sleep apnea and daytime sleepiness and fatigue: Relation to visceral obesity, insulin resistance, and hypercytokinemia. J Clin Endocrinol Metab 85, 1151–1158.
Vgontzas, A.N., Zoumakis, M., Bixler, E.O., Lin, H.M., Prolo, P., Vela-Bueno, A., Kales, A., and Chrousos, G.P. (2003) Impaired nighttime sleep in healthy old versus young adults is associated with elevated plasma interleukin-6 and cortisol levels: Physiologic and therapeutic implications. J Clin Endocrinol Metab 88, 2087–2095.
Vgontzas, A.N., Bixler, E., and Chrousos, G.P. (2005) Sleep apnea is a manifestation of the metabolic syndrome. Sleep Med Rev 9, 211–224.
Yokoe, T., Minoguchi, K., Matsuo, H., Oda, N., Minoguchi, H., Yoshino, G., Hirano, T., and Adachi, M. (2003) Elevated levels of C-reactive protein and interleukin-6 in patients with obstructive sleep apnea syndrome are decreased by nasal continuous positive airway pressure. Circulation 107, 1129–1134.
Yoon, I.Y., and Jeong, D.U. (2001) Degree of arousal is most correlated with blood pressure reactivity during sleep in obstructive sleep apnea. J Korean Med Sci 16, 707–711.
Ziegler, M., Kennedy, B, Morrissey, E., and O'Connor, D. (1990) Norepinephrine clearance, chromogranin A and dopamine beta hydroxylase in renal failure. Kidney Int 37, 1357–1362.
Ziegler, M.G., Nelesen, R., Mills, P.J., Ancoli-Israel, S., Kennedy, B., and Dimsdale, J. (1997) Sleep apnea, norepinephrine-release rate, and daytime hypertension. Sleep 20, 224–231.
Ziegler, M.G., Mills, P.J., Loredo, J., Ancoli-Israel, S., and Dimsdale, J. (2001) Effect of continuous positive airway pressure and placebo treatment on sympathetic nervous activity in patients with obstructive sleep apnea. Chest 120, 887–893.
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Mills, P.J., Ziegler, M.G., Dimsdale, J.E. (2007). Neuroimmune Activation in Sleep Apnea. In: Pandi-Perumal, S., Cardinali, D.P., Chrousos, G.P. (eds) Neuroimmunology of Sleep. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-69146-6_15
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DOI: https://doi.org/10.1007/978-0-387-69146-6_15
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