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Traumatic Optic Neuropathies

  • Chapter
Optic Nerve Disorders

Abstract

Traumatic optic neuropathy may be a result of severe head trauma or may be associated with little or no evidence of head injury. Traumatic optic neuropathy occurs in approximately 0.5% to 5% of closed head injuries1 and in 2.5% of patients with maxillofacial trauma and midface fractures.2 Loss of consciousness is associated with traumatic optic neuropathy in 40% to 70% of cases.3,4 In closed head injuries, the site of injury causing blindness is often the forehead or supraorbital ridge, less commonly the temporal region. Patients from 20 to 40 years of age represent the major trauma population who experience traumatic optic neuropathy.5

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References

  1. Steinsapir KD, Goldberg RA. Traumatic optic neuropathy. Surv Ophthalmol 1994;38(6):487–518.

    PubMed  CAS  Google Scholar 

  2. Al-Qurainy IA, Stassen LF, Dutton GN, Moos KF, el-Attar A. The characteristics of midfacial fractures and the association with ocular injury: a prospective study. Br J Oral Maxillofac Surg 1991;29(5):291–301.

    PubMed  CAS  Google Scholar 

  3. Edmund J, Godfretsen E. Unilateral optic atrophy following head injury. Acta Ophthalmol (Copenh) 1963;41:693–697.

    CAS  Google Scholar 

  4. Seiff SR. High dose corticosteroids for treatment of vision loss due to indirect injury to the optic nerve. Ophthalmic Surg 1990;21(6):389–395.

    PubMed  CAS  Google Scholar 

  5. Levin LA, Joseph MP, Rizzo JF III, Lessell S. Optic canal decompression in indirect optic nerve trauma. Ophthalmology 1994;101(3):566–569.

    PubMed  CAS  Google Scholar 

  6. Lessell S. Indirect optic nerve trauma. Arch Ophthalmol 1989;107(3):382–386.

    PubMed  CAS  Google Scholar 

  7. Spoor TC. Treatment of optic neuropathy with megadose corticosteroids. Arch Ophthalmol 1986;104(11):1585.

    PubMed  CAS  Google Scholar 

  8. Mauriello JA, DeLuca J, Krieger A, Schulder M, Frohman L. Management of traumatic optic neuropathy: a study of 23 patients. Br J Ophthalmol 1992;76(6):349–342.

    PubMed  CAS  Google Scholar 

  9. Steinsapir KD, Goldberg RA. Traumatic optic neuropathies. In: Miller NR, Newman NJ, editors. Walsh and Hoyt’s clinical neuroophthalmology, 5th ed. Baltimore: Williams & Wilkins; 1998. p. 715–740.

    Google Scholar 

  10. Sadun AA. Anatomy and physiology of the optic nerve. In: Miller NR, Newman NJ, editors. Walsh and Hoyt’s clinical neuroophthalmology, 5th ed. Baltimore: Williams & Wilkins; 1998. p. 57–83.

    Google Scholar 

  11. Lang J. Clinical anatomy of the nose, nasal cavity, and paranasal sinuses. Stuttgart: Thieme Verlag; 1989. p. 85–98, 125–128.

    Google Scholar 

  12. Bilyk JR, Joseph MP. Traumatic optic neuropathy. Semin Ophthalmol. 1994;9(3):200–211.

    PubMed  CAS  Google Scholar 

  13. Hupp SL, Buckley EG, Byrne SF, Tenzel RR, Glaser JS, Schatz NS. Posttraumatic venous obstructive retinopathy associated withenlarged optic nerve sheath. Arch Ophthalmol 1984;102(2):254–256.

    PubMed  CAS  Google Scholar 

  14. Guy J, Sherwood M, Day AL. Surgical treatment of progressive visual loss in traumatic optic neuropathy. Report of two cases. J Neurosurg 1989;70(5):799–801.

    CAS  Google Scholar 

  15. Lessell S. Traumatic optic neuropathy and visual system injury. In: Shingleton BJ, Hersh PS, Kenyon KR, editors. Eye trauma. St. Louis: Mosby; 1991. p. 371–379.

    Google Scholar 

  16. Gross CE, DeKock JR, Panje WR, Hershkowitz N, Newman J. Evidence for orbital deformation that may contribute to monocular blindness following minor frontal head trauma. J Neurosurg 1981;55(6):963–966.

    PubMed  CAS  Google Scholar 

  17. Anderson RL, Panje WR, Gross CE. Optic nerve blindness following blunt forehead trauma. Ophthalmology 1982;89(5):445–455.

    PubMed  CAS  Google Scholar 

  18. Crompton MR. Visual lesions in closed head injury. Brain 1970;93(4):785–792.

    PubMed  CAS  Google Scholar 

  19. Frenkel RE, Spoor TC. Diagnosis and management of traumatic optic neuropathies. Adv Ophthalmic Plast Reconstr Surg. 1987;6:71–90.

    PubMed  CAS  Google Scholar 

  20. Krauss HR, Yee RD, Foos RY. Autoenucleation. Surv Ophthalmol 1984;29(3):179–187.

    PubMed  CAS  Google Scholar 

  21. Goodhart SP. Avulsion of both eyeballs and extraction of teeth: self-mutilation in chronic encephalitis. Am J Med Sci 1933;185:674–684.

    Google Scholar 

  22. Coppez H, Surle S. Pseudo-corps estrangers de l’oeil. Arch Ophthalmol 1929;46:449–457.

    Google Scholar 

  23. Park JH, Frenkel M, Dobbie JG, Choromokos E. Evulsion of the optic nerve. Am J Ophthalmol 1971;72(5):969–971.

    PubMed  CAS  Google Scholar 

  24. Hedges TR III, Gragoudas ES. Traumatic anterior ischemic optic neuropathy. Ann Ophthalmol 1981;13(5):625–628.

    PubMed  Google Scholar 

  25. Crowe NW, Nickles TP, Troost BT, Elster AD. Intrachiasmal hemorrhage: a cause of delayed post-traumatic blindness. Neurology 1989;39(6):863–865.

    PubMed  CAS  Google Scholar 

  26. Manor RS, Cohen S, Svetliza E, Ben Sira I. Papilledema in traumatic lesion of optic nerve with amaurosis. J Clin Neuro Ophthalmol 1986;6(2):100–105.

    CAS  Google Scholar 

  27. Holmes MD, Sires BS. Flash visual evoked potentials predict visual outcome in traumatic optic neuropathy. Ophthalmic Plast Reconstr Surg 2004;20(5):342–346.

    Google Scholar 

  28. Cornelius CP, Altenmuller E, Ehrenfeld M. The use of flash visual evoked potentials in the early diagnosis of suspected optic nerve lesions due to craniofacial trauma. J Craniomaxillofac Surg 1996;24(1):1–11.

    PubMed  CAS  Google Scholar 

  29. Jayle GE, Tassy AF. Prognostic value of the electroretinogram in severe recent ocular trauma. Br J Ophthalmol 1970;54(1):51–58.

    PubMed  CAS  Google Scholar 

  30. Hooper RS. Orbital complications of head injury. Br J Surg 1951;39(154):126–138.

    PubMed  CAS  Google Scholar 

  31. Hughes B. Indirect injury of the optic nerves and chiasma. Bull Johns Hopkins Hosp 1962;111:98–126.

    PubMed  CAS  Google Scholar 

  32. Turner JWA. Indirect injury of the optic nerves. Brain 1943;66:140–151.

    Google Scholar 

  33. Medeiros FA, Sample PA, Zangwill LM, Bowd C, Aihara M, Weinreb RN. Corneal thickness as a risk factor for visual field loss in patients with preperimetric glaucomatous optic neuropathy. Am J Ophthalmol 2003;136(5):805–813.

    PubMed  Google Scholar 

  34. Lundstrom M, Frisen L. Evolution of descending optic atrophy. A case report. Acta Ophthalmol (Copenh) 1975;53(5):738–746.

    CAS  Google Scholar 

  35. Miyahara T, Kurimoto Y, Kurokawa T, Kuroda T, Yoshimura N. Alterations in retinal nerve fiber layer thickness following indirect traumatic optic neuropathy detected by nerve fiber analyzer, GDx-N. Am J Ophthalmol 2003;136(2):361–364.

    PubMed  Google Scholar 

  36. Keane JR, Baloh RW. Posttraumatic cranial neuropathies. Neurol Clin 1992;10(4):849–867.

    PubMed  CAS  Google Scholar 

  37. Wang ML, Seiff SR, Drasner K. A comparison of visual outcome in open-globe repair: succinylcholine with d-tubocurarine vs nondepolarizing agents. Ophthalmic Surg 1992;23(11):746–751.

    PubMed  CAS  Google Scholar 

  38. Seiff SR, Berger MS, Guyon J, Pitts LH. Computed tomographic evaluation of the optic canal in sudden traumatic blindness. Am J Ophthalmol 1984;98(6):751–755.

    PubMed  CAS  Google Scholar 

  39. Tang RA, Kramer LA, Schiffman J, Woon C, Hayman LA, Pardo G. Chiasmal trauma: clinical and imaging considerations. Surv Ophthalmol 1994;38(4):381–383.

    PubMed  CAS  Google Scholar 

  40. Moffit B, Duffy K, Lufkin R, Frazee J, Vinuela F, Bentson J. MR imaging of intrachiasmatic hemorrhage. J Comput Assist Tomogr 1988;12(3):535–536.

    PubMed  CAS  Google Scholar 

  41. Levin LA, Rubin PA. Advances in orbital imaging. Int Ophthalmol Clin 1992;32(3):1–25.

    PubMed  CAS  Google Scholar 

  42. Kline LB, McCluskey MM, Skalka HW. Imaging techniques in optic nerve evulsion. J Clin Neuro-Ophthalmol 1988;8(4):281–282.

    CAS  Google Scholar 

  43. Talwar D, Kumar A, Verma L, Tewari HK, Khosla PK. Ultrasonography in optic nerve head avulsion. Acta Ophthalmol (Copenh) 1991;69(1):121–123.

    CAS  Google Scholar 

  44. Guthoff RF, Berger RW, Winkler P, Helmke K, Chumbley LC. Doppler ultrasonography of the ophthalmic and central retinal vessels. Arch Ophthalmol 1991;109(4):532–536.

    PubMed  CAS  Google Scholar 

  45. Erickson SJ, Hendrix LE, Massaro BM, et al. Color Doppler flow imaging of the normal and abnormal orbit. Radiology 1989;173(2):511–516.

    PubMed  CAS  Google Scholar 

  46. Millesi W, Hollmann K, Funder J. Traumatic lesion of the optic nerve. Acta Neurochir (Wien) 1988;93(1–2):50–54.

    CAS  Google Scholar 

  47. Tang R, Li H, Regner V. Traumatic optic neuropathy: analysis of 37 cases. Philadelphia: Lippincott; 1986.

    Google Scholar 

  48. Carta A, Ferrigno L, Salvo M, Bianchi-Marzoli S, Boschi A, Carta F. Visual prognosis after indirect traumatic optic neuropathy. J Neurol Neurosurg Psychiatry 2003;74(2):246–248.

    PubMed  CAS  Google Scholar 

  49. Brodsky MC, Wald KJ, Chen S, Weiter JJ. Protracted posttraumatic optic disc swelling. Ophthalmology 1995;102(11):1628–1631.

    PubMed  CAS  Google Scholar 

  50. Povlishock JT, Becker DP, Cheng CL, Vaughan GW. Axonal change in minor head injury. J Neuropathol Exp Neurol 1983;42(3):225–242.

    PubMed  CAS  Google Scholar 

  51. Buchi ER. Cell death in the rat retina after a pressure-induced ischaemia-reperfusion insult: an electron microscopic study. I. Ganglion cell layer and inner nuclear layer. Exp Eye Res 1992;55(4):605–613.

    PubMed  CAS  Google Scholar 

  52. Garcia-Valenzuela E, Gorczyca W, Darzynkiewicz Z, Sharma SC. Apoptosis in adult retinal ganglion cells after axotomy. J Neurobiol 1994;25(4):431–438.

    PubMed  CAS  Google Scholar 

  53. Levin LA, Louhab A. Apoptosis of retinal ganglion cells in anterior ischemic optic neuropathy. Arch Ophthalmol 1996;114(4):488–491.

    PubMed  CAS  Google Scholar 

  54. Vorwerk CK, Zurakowski D, McDermott LM, Mawrin C, Dreyer EB. Effects of axonal injury on ganglion cell survival and glutamate homeostasis. Brain Res Bull 2004;62(6):485–490.

    PubMed  CAS  Google Scholar 

  55. Solary E, Eymin B, Droin N, Haugg M. Proteases, proteolysis, and apoptosis. Cell Biol Toxicol 1998;14(2):121–132.

    PubMed  CAS  Google Scholar 

  56. Dugan LL, Sensi SL, Canzoniero LM, et al. Mitochondrial production of reactive oxygen species in cortical neurons following exposure to N-methyl-d-aspartate. J Neurosci 1995;15(10):6377–6388.

    PubMed  CAS  Google Scholar 

  57. Fehsel K, Kroncke KD, Meyer KL, Huber H, Wahn V, Kolb-Bachofen V. Nitric oxide induces apoptosis in mouse thymocytes. J Immunol 1995;155(6):2858–2865.

    PubMed  CAS  Google Scholar 

  58. Greenlund LJ, Korsmeyer SJ, Johnson EM Jr. Role of BCL-2 in the survival and function of developing and mature sympathetic neurons. Neuron 1995;15(3):649–661.

    PubMed  CAS  Google Scholar 

  59. Messmer UK, Ankarcrona M, Nicotera P, Brune B. p53 expression in nitric oxide-induced apoptosis. FEBS Lett 1994;355(1):23–26.

    PubMed  CAS  Google Scholar 

  60. Lau KC, So KF, Tay D, Leung MC. NADPH-diaphorase neurons in the retina of the hamster. J Comp Neurol 1994;350(4):550–558.

    PubMed  CAS  Google Scholar 

  61. Kuehn MH, Fingert JH, Kwon YH. Retinal ganglion cell death in glaucoma: mechanisms and neuroprotective strategies. Ophthalmol Clin N Am 2005;18(3):383–395, vi.

    Google Scholar 

  62. Kanellopoulos GK, Xu XM, Hsu CY, Lu X, Sundt TM, Kouchoukos NT. White matter injury in spinal cord ischemia: protection by AMPA/ kainite glutamate receptor antagonism. Stroke 2000;31(8):1945–1952.

    PubMed  CAS  Google Scholar 

  63. Schuettauf F, Naskar R, Vorwerk CK, Zurakowski D, Dreyer EB. Ganglion cell loss after optic nerve crush mediated through AMPA-kainate and NMDA receptors. Invest Ophthalmol Vis Sci 2000;41(13):4313–4316.

    PubMed  CAS  Google Scholar 

  64. Bracken MB, Shepard MJ, Collins WF, et al. A randomized, controlled trial of methylprednisolone or naloxone in the treatment of acute spinal-cord injury. Results of the Second National Acute Spinal Cord Injury Study. N Engl J Med 1990;322(20):1405–1411.

    PubMed  CAS  Google Scholar 

  65. Levin LA, Beck RW, Joseph MP, Seiff S, Kraker R. The treatment of traumatic optic neuropathy: the International Optic Nerve Trauma Study. Ophthalmology 1999;106(7):1268–1277.

    PubMed  CAS  Google Scholar 

  66. Steinsapir KD, Goldberg RA, Sinha S, Hovda DA. Methylprednisolone exacerbates axonal loss following optic nerve trauma in rats. Restor Neurol Neurosci 2000;17(4):157–163.

    PubMed  CAS  Google Scholar 

  67. Steinsapir KD, Seiff SR, Goldberg RA. Traumatic optic neuropathy: where do we stand? Ophthalmic Plast Reconstr Surg 2002;18(3):232–234.

    Google Scholar 

  68. Ohlsson M, Westerlund U, Langmoen IA, Svensson M. Methylprednisolone treatment does not influence axonal regeneration or degeneration following optic nerve injury in the adult rat. J Neuro-Ophthalmol 2004;24(1):11–18.

    Google Scholar 

  69. Kayan A, Earl CJ. Compressive lesions of the optic nerves and chiasm. Pattern of recovery of vision following surgical treatment. Brain 1975;98(1):13–28.

    CAS  Google Scholar 

  70. McDonald WI. The symptomatology of tumours of the anterior visual pathways. Can J Neurol Sci 1982;9(4):381–390.

    PubMed  CAS  Google Scholar 

  71. McCann JD, Seiff S. Traumatic neuropathies of the optic nerve, optic chiasm, and ocular motor nerves. Curr Opin Ophthalmol 1994;5(6):3–10.

    PubMed  CAS  Google Scholar 

  72. Fujitani T, Inoue K, Takahashi T, Ikushima K, Asai T. Indirect traumatic optic neuropathy: visual outcome of operative and nonoperative cases. Jpn J Ophthalmol 1986;30(1):125–134.

    PubMed  CAS  Google Scholar 

  73. Mahapatra AK, Tandon DA. Traumatic optic neuropathy in children: a prospective study. Pediatr Neurosurg 1993;19(1):34–39.

    PubMed  CAS  Google Scholar 

  74. Girard BC, Bouzas EA, Lamas G, Soudant J. Visual improvement after transethmoidsphenoid decompression in optic nerve injuries. J Clin Neuro-Ophthalmol 1992;12(3):142–148.

    CAS  Google Scholar 

  75. Bracken MB, Holford TR. Effects of timing of methylprednisolone or naloxone administration on recovery of segmental and long-tract neurological function in NASCIS 2. J Neurosurg 1993;79(4):500–507.

    PubMed  CAS  Google Scholar 

  76. Joseph MP, Lessell S, Rizzo J, Momose KJ. Extracranial optic nerve decompression for traumatic optic neuropathy. Arch Ophthalmol 1990;108(8):1091–1093.

    PubMed  CAS  Google Scholar 

  77. Miller NR. The management of traumatic opticneuropathy. Arch Ophthalmol 1990;108(8):1086.

    PubMed  CAS  Google Scholar 

  78. Sofferman RA. An extracranial microsurgical approach to the optic nerve. J Microsurg 1979;1(3):195–202.

    PubMed  CAS  Google Scholar 

  79. Goldberg RA, Steinsapir KD. Extracranial optic canal decompression: indications and technique. Ophthalmic Plast Reconstr Surg 1996;12(3):163–170.

    CAS  Google Scholar 

  80. Kountakis SE, Maillard AA, Urso R, Stiernberg CM. Endoscopic approach to traumatic visual loss. Otolaryngol Head Neck Surg 1997;116(6pt 1):652–655.

    PubMed  CAS  Google Scholar 

  81. Rajiniganth MG, Gupta AK, Gupta A, Bapuraj JR. Traumatic optic neuropathy: visual outcome following combined therapy protocol. Arch Otolaryngol Head Neck Surg 2003;129(11):1203–1206.

    PubMed  CAS  Google Scholar 

  82. Goldenberg-Cohen N, Miller NR, Repka MX. Traumatic optic neuropathy in children and adolescents. J AAPOS 2004;8(1):20–27.

    PubMed  Google Scholar 

  83. Shoulson I. Experimental therapeutics of neurodegenerative disorders: unmet needs. Science 1998;282(5391):1072–1074.

    PubMed  CAS  Google Scholar 

  84. Kipnis J, Yoles E, Porat Z, et al. T cell immunity to copolymer 1 confers neuroprotection on the damaged optic nerve: possible therapy for optic neuropathies. Proc Natl Acad Sci U S A 2000;97(13):7446–7451.

    PubMed  CAS  Google Scholar 

  85. Kipnis J, Yoles E, Schori H, Hauben E, Shaked I, Schwartz M. Neuronal survival after CNS insult is determined by a genetically encoded autoimmune response. J Neurosci 2001;21(13):4564–4571.

    PubMed  CAS  Google Scholar 

  86. Schwartz M, Cohen IR. Autoimmunity can benefit self-maintenance. Immunol Today 2000;21(6):265–268.

    PubMed  CAS  Google Scholar 

  87. Hirschberg DL, Moalem G, He J, Mor F, Cohen IR, Schwartz M. Accumulation of passively transferred primed T cells independently of their antigen specificity following central nervous system trauma. J Neuroimmunol 1998;89(1–2):88–96.

    PubMed  CAS  Google Scholar 

  88. Schori H, Kipnis J, Yoles E, et al. Vaccination for protection of retinal ganglion cells against death from glutamate cytotoxicity and ocular hypertension: implications for glaucoma. Proc Natl Acad Sci U S A 2001;98(6):3398–3403.

    PubMed  CAS  Google Scholar 

  89. Schwartz M. Physiological approaches to neuroprotection: boosting of protective autoimmunity. Surv Ophthalmol 2001;45(suppl 3):S256–260.

    PubMed  Google Scholar 

  90. Moalem G, Gdalyahu A, Shani Y, et al. Production of neurotrophins by activated T cells: implications for neuroprotective autoimmunity. J Autoimmun 2000;15(3):331–345.

    PubMed  CAS  Google Scholar 

  91. Moalem G, Leibowitz-Amit R, Yoles E, Mor F, Cohen IR, Schwartz M. Autoimmune T cells protect neurons from secondary degeneration after central nervous system axotomy. Nat Med 1999;5(1):49–55.

    PubMed  CAS  Google Scholar 

  92. Moalem G, Yoles E, Leibowitz-Amit R, et al. Autoimmune T cells retard the loss of function in injured rat optic nerves. J Neuroimmunol 2000;106(1–2):189–197.

    PubMed  CAS  Google Scholar 

  93. Hare W, WoldeMussie E, Lai R, et al. Efficacy and safety of memantine, an NMDA-type openchannel blocker, for reduction of retinal injury associated with experimental glaucoma in rat and monkey. Surv Ophthalmol 2001;45(suppl 3):S284–289.

    PubMed  Google Scholar 

  94. Kikuchi M, Tenneti L, Lipton SA. Role of p38 mitogen-activated protein kinase in axotomyinduced apoptosis of rat retinal ganglion cells. J Neurosci 2000;20(13):5037–5044.

    PubMed  CAS  Google Scholar 

  95. Lam TT, Tso MO. Nitric oxide synthase (NOS) inhibitors ameliorate retinal damage induced by ischemia in rats. Res Commun Mol Pathol Pharmacol 1996;92(3):329–340.

    PubMed  CAS  Google Scholar 

  96. Levkovitch-Verbin H, Harris-Cerruti C, Groner Y, Wheeler LA, Schwartz M, Yoles E. RGC death in mice after optic nerve crush injury: oxidative stress and neuroprotection. Invest Ophthalmol Vis Sci 2000;41(13):4169–4174.

    PubMed  CAS  Google Scholar 

  97. Yoles E, Wheeler LA, Schwartz M. Alpha2-adrenoreceptor agonists are neuroprotective in a rat model of optic nerve degeneration. Invest Ophthalmol Vis Sci 1999;40(1):65–73. Erratum in Invest Ophthalmol Vis Sci 1999;40(11):2470.

    PubMed  CAS  Google Scholar 

  98. Green DR. Apoptotic pathways: the roads to ruin. Cell 1998;94(6):695–698.

    PubMed  CAS  Google Scholar 

  99. Kermer P, Klocker N, Labes M, Bahr M. Inhibition of CPP32-like proteases rescues axotomized retinal ganglion cells from secondary cell death in vivo. J Neurosci 1998;18(12):4656–4662.

    PubMed  CAS  Google Scholar 

  100. Teng YD, Mocchetti I, Taveira-DaSilva AM, Gillis RA, Wrathall JR. Basic fibroblast growth factor increases long-term survival of spinal motor neurons and improves respiratory function after experimental spinal cord injury. J Neurosci 1999;19(16):7037–7047.

    PubMed  CAS  Google Scholar 

  101. Chen H, Weber AJ. BDNF enhances retinal ganglion cell survival in cats with optic nerve damage. Invest Ophthalmol Vis Sci 2001;42(5):966–974.

    PubMed  CAS  Google Scholar 

  102. Fan D, Ogawa M, Ikeguchi K, et al. Prevention of dopaminergic neuron death by adeno-associated virus vector-mediated GDNF gene transfer in rat mesencephalic cells in vitro. Neurosci Lett 1998;248(1):61–64.

    PubMed  CAS  Google Scholar 

  103. Gimenez Y, Ribotta M, Revah F, et al. Prevention of motoneuron death by adenovirus-mediated neurotrophic factors. J Neurosci Res 1997;48(3):281–285.

    Google Scholar 

  104. Cui Q, Cho KS, So KF, Yip HK. Synergistic effect of Nogo-neutralizing antibody IN-1 and ciliary neurotrophic factor on axonal regeneration in adult rodent visual systems. J Neurotrauma 2004;21(5):617–625.

    PubMed  Google Scholar 

  105. Chierzi S, Strettoi E, Cenni MC, Maffei L. Optic nerve crush: axonal responses in wild-type and bcl-2 transgenic mice. J Neurosci 1999;19(19):8367–8376.

    PubMed  CAS  Google Scholar 

  106. Lehmann M, Fournier A, Selles-Navarro I, et al. Inactivation of Rho signaling pathway promotes CNS axon regeneration. J Neurosci 1999;19(17):7537–7547.

    PubMed  CAS  Google Scholar 

  107. von Bartheld CS. Neurotrophins in the developing and regenerating visual system. Histol Histopathol 1998;13(2):437–459.

    Google Scholar 

  108. Lindqvist N, Peinado-Ramonn P, Vidal-Sanz M, Hallbook F. GDNF, Ret, GFRalpha1 and 2 in the adult rat retino-tectal system after optic nerve transection. Exp Neurol. 2004 Jun;187(2):487–499.

    PubMed  CAS  Google Scholar 

  109. Munoz DG, Ha T, Uitti RJ. Neurite extension on dibutyryl cyclic AMP-stimulated astrocytes. Exp Neurol 1988;101(3):374–384.

    PubMed  CAS  Google Scholar 

  110. Martin KR, Quigley HA. Gene therapy for optic nerve disease. Eye 2004;18(11):1049–1055.

    PubMed  CAS  Google Scholar 

  111. Li S, Hu B, Tay D, So KF, Yip HK. Intravitreal transplants of Schwann cells and fibroblasts promote the survival of axotomized retinal ganglion cells in rats. Brain Res 2004;1029(1):56–64.

    PubMed  CAS  Google Scholar 

  112. Vidal-Sanz M, Bray GM, Aguayo AJ. Regenerated synapses persist in the superior colliculus after the regrowth of retinal ganglion cell axons. J Neurocytol 1991;20(11):940–952. Erratum in J Neurocytol 1992;21 (3):234.

    PubMed  CAS  Google Scholar 

  113. Aviles-Trigueros M, Sauve Y, Lund RD, VidalSanz M. Selective innervation of retinorecipient brainstem nuclei by retinal ganglion cell axons regenerating through peripheral nerve grafts in adult rats. J Neurosci 2000;20(1):361–374.

    PubMed  CAS  Google Scholar 

  114. Sauve Y, Sawai H, Rasminsky M. Topological specificity in reinnervation of the superior colliculus by regenerated retinal ganglion cell axons in adult hamsters. J Neurosci 2001;21(3):951–960.

    PubMed  CAS  Google Scholar 

  115. Thanos S, Naskar R, Heiduschka P. Regenerating ganglion cell axons in the adult rat establish retinofugal topography and restore visual function. Exp Brain Res 1997;114(3):483–491.

    PubMed  CAS  Google Scholar 

  116. Ahmad I, Tang L, Pham H. Identification of neural progenitors in the adult mammalian eye. Biochem Biophys Res Commun 2000;270(2):517–521.

    PubMed  CAS  Google Scholar 

  117. Tropepe V, Coles BL, Chiasson BJ, et al. Retinal stem cells in the adult mammalian eye. Science 2000;287(5460):2032–2036.

    PubMed  CAS  Google Scholar 

  118. Song HJ, Stevens CF, Gage FH. Neural stem cells from adult hippocampus develop essential properties of functional CNS neurons. Nat Neurosci 2002;5(5):438–445.

    PubMed  CAS  Google Scholar 

  119. Hallas BH, Lowe HF, Jacobsen G, LaCorte M, Lee SP, Zanakis MF. Developing retina and PNS segments for transplantation into the adult host eye: reconstruction of the mammalian visual system. 2. Results. J Neural Transplant 1989;1(3–4):87–93.

    PubMed  CAS  Google Scholar 

  120. Cheng L, Sapieha P, Kittlerova P, Hauswirth WW, Di Polo A. TrkB gene transfer protects retinal ganglion cells from axotomy-induced death in vivo. J Neurosci 2002;22(10):3977–3986.

    PubMed  CAS  Google Scholar 

  121. Straten G, Schmeer C, Kretz A, et al. Potential synergistic protection of retinal ganglion cells from axotomy-induced apoptosis by adenoviral administration of glial cell line-derived neurotrophic factor and X-chromosome-linked inhibitor of apoptosis. Neurobiol Dis 2002;11(1):123–133.

    PubMed  CAS  Google Scholar 

  122. Devoto MH, Kersten RC, Zalta AH, Kulwin DR. Optic nerve injury after retrobulbar anesthesia. Arch Ophthalmol 1997;115(5):687–688.

    PubMed  CAS  Google Scholar 

  123. Dorey SE, Gillespie IH, Barton F, MacSweeney E. Magnetic resonance image changes following optic nerve trauma from peribulbar anaesthetic. Br J Ophthalmol 1998;82(5):586–587.

    PubMed  CAS  Google Scholar 

  124. Horton JC, Hoyt WF, Foreman DS, Cohen JA. Confirmation by magnetic resonance imaging of optic nerve injury after retrobulbar anesthesia. Arch Ophthalmol 1996;114(3):351–353.

    PubMed  CAS  Google Scholar 

  125. Kim SK, Golden MA, Bradbury MJ, Rizzo JF. First description of optic neuropathy secondary to sub-Tenon’s anesthesia in cataract surgery. Invest Ophthalmol Vis Sci 2000;41(4):S314.

    Google Scholar 

  126. Katsev DA, Drews RC, Rose BT. An anatomic study of retrobulbar needle path length. Ophthalmology 1989;96(8):1221–1224.

    PubMed  CAS  Google Scholar 

  127. Carroll FD. Optic nerve complications of cataract extraction. Trans Am Acad Ophthalmol Otolaryngol 1973;77(5):OP623–629.

    PubMed  CAS  Google Scholar 

  128. Hayreh SS. Anterior ischemic optic neuropathy. IV. Occurrence after cataract extraction. Arch Ophthalmol 1980;98(8):1410–1416.

    PubMed  CAS  Google Scholar 

  129. Luscavage LE, Volpe NJ, Liss R. Posterior ischemic optic neuropathy after uncomplicated cataract extraction. Am J Ophthalmol 2001;132(3):408–409.

    PubMed  CAS  Google Scholar 

  130. Michaels DD, Zugsmith GS. Optic neuropathy following cataract extraction. Ann Ophthalmol 1973;5(3):303–306.

    PubMed  CAS  Google Scholar 

  131. Serrano LA, Behrens MM, Carroll FD. Postcataract extraction ischemic optic neuropathy. Arch Ophthalmol 1982;100(7):1177–1178.

    PubMed  CAS  Google Scholar 

  132. McCulley TJ, Lam BL, Feuer WJ. Incidence of nonarteritic anterior ischemic optic neuropathy associated with cataract extraction. Ophthalmology 2001;108(7):1275–1278.

    PubMed  CAS  Google Scholar 

  133. McCulley TJ, Lam BL, Feuer WJ. Nonarteritic anterior ischemic optic neuropathy and surgery of the anterior segment: temporal relationship analysis. Am J Ophthalmol 2003;136(6):1171–1172.

    PubMed  Google Scholar 

  134. Hattenhauer MG, Leavitt JA, Hodge DO, Grill R, Gray DT. Incidence of nonarteritic anterior ischemic optic neuropathy. Am J Ophthalmol 1997;123(1):103–107.

    PubMed  CAS  Google Scholar 

  135. Boldt HC, Munden PM, Folk JC, Mehaffey MG. Visual field defects after macular hole surgery. Am J Ophthalmol 1996;122(3):371–381.

    PubMed  CAS  Google Scholar 

  136. Ezra E, Arden GB, Riordan-Eva P, Aylward GW, Gregor ZJ. Visual field loss following vitrectomy for stage 2 and 3 macular holes. Br J Ophthalmol 1996;80(6):519–525.

    PubMed  CAS  Google Scholar 

  137. Hutton WL, Fuller DG, Snyder WB, Fellman RL, Swanson WH. Visual field defects after macular hole surgery. A new finding. Ophthalmology 1996;103(12):2152–2158.

    CAS  Google Scholar 

  138. Kerrison JB, Haller JA, Elman M, Miller NR. Visual field loss following vitreous surgery. Arch Ophthalmol 1996;114(5):564–569.

    PubMed  CAS  Google Scholar 

  139. Melberg NS, Thomas MA. Visual field loss after pars plana vitrectomy with air/fluid exchange. Am J Ophthalmol 1995;120(3):386–388.

    PubMed  CAS  Google Scholar 

  140. Paques M, Massin P, Santiago PY, Spielmann AC, Gaudric A. Visual field loss after vitrectomy for full-thickness macular holes. Am J Ophthalmol 1997;124(1):88–94.

    PubMed  CAS  Google Scholar 

  141. Costa VP, Smith M, Spaeth GL, Gandham S, Markovitz B. Loss of visual acuity after trabeculectomy. Ophthalmology 1993;100(5):599–612.

    PubMed  CAS  Google Scholar 

  142. Kolker AE. Visual prognosis in advanced glaucoma: a comparison of medical and surgical therapy for retention of vision in 101 eyes with advanced glaucoma. Trans Am Ophthalmol Soc 1977;75:539–555.

    PubMed  CAS  Google Scholar 

  143. Kawasaki A, Purvin V. Unilateral optic disc edema following trabeculectomy. J Neuro-Ophthalmol 1998;18(2):121–123.

    CAS  Google Scholar 

  144. DeMere M, Wood T, Austin W. Eye complications with blepharoplasty or other eyelid surgery. A national survey. Plast Reconstr Surg 1974;53(6):634–637.

    CAS  Google Scholar 

  145. Kelly PW, May DR. Central retinal artery occlusion following cosmetic blepharoplasty. Br J Ophthalmol 1980;64(12):918–922.

    PubMed  CAS  Google Scholar 

  146. Anderson RL. Bilateral visual loss after blepharoplasty. Arch Ophthalmol 1981;99(12):2205.

    PubMed  CAS  Google Scholar 

  147. Goldberg RA, Marmor MF, Shorr N, Christenbury JD. Blindness following blepharoplasty: two case reports, and a discussion of management. Ophthalmic Surg 1990;21(2):85–89.

    PubMed  CAS  Google Scholar 

  148. Savino PJ, Burde RM, Mills RP. Visual loss following intranasal anesthetic injection. J Clin Neuro-Ophthalmol 1990;10(2):140–144.

    CAS  Google Scholar 

  149. Bolger WE, Keyes AS, Lanza DC. Use of the superior meatus and superior turbinate in the endoscopic approach to the sphenoid sinus. Otolaryngol Head Neck Surg 1999;120(3):308–313.

    PubMed  CAS  Google Scholar 

  150. Driben JS, Bolger WE, Robles HA, Cable B, Zinreich SJ. The reliability of computerized tomographic detection of the Onodi (sphenoethmoid) cell. Am J Rhinol 1998;12(2):105–111.

    PubMed  CAS  Google Scholar 

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  1. Ophthalmology and Neurology, University of Kentucky College of Medicine, Lexington, KY, USA

    Jane W. Chan MD (Assciate Professor)

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Chan, J.W. (2007). Traumatic Optic Neuropathies. In: Optic Nerve Disorders. Springer, New York, NY. https://doi.org/10.1007/978-0-387-68979-1_5

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