Skip to main content

Role of the Golgi Apparatus During Axon Formation

  • Chapter
Intracellular Mechanisms for Neuritogenesis

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 89.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 119.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Abo, A., Qu, J., Cammarano, M., Dan, C., Fritsch, A., Baud, A., et al., 1998, PAK4, a novel effector for Cdc42Hs, is implicated in the reorganization of the actin cytoskeleton and in the formation of filopodia, EMBO J. 22: 6527–6540.

    Google Scholar 

  • Ayala, J., Touchot, N., Zahraoui, A., Tavitian, A., and Prochiantz, A., 1990, The product of rab2, a small GTP binding protein, increases neuronal adhesion, and neurite growth in vitro, Neuron 4: 797–805.

    PubMed  CAS  Google Scholar 

  • Baron, C., and Malhotra, V., 2000, Role of dyacylglycerol in PKD recruitment to the TGN and protein transport to the plasma membrane, Science 295: 325–328.

    Google Scholar 

  • Barr, F.A., and Short, B., 2003, Golgins in the structure and dynamics of the Golgi apparatus, Curr. Opin. Cell Biol. 15: 405–413.

    PubMed  CAS  Google Scholar 

  • Barr, F., Puype. M., Vandekerckhove, J., and Warren, G., 1997, GRASP65, a protein involved in the stacking of Golgi cisternae, Cell 91: 253–262.

    PubMed  CAS  Google Scholar 

  • Bradke, F., and Dotti, C.G., 1997, Neuronal polarity: Vectorial cytoplasmic flow precedes axon formation, Neuron 19: 1175–1186.

    PubMed  CAS  Google Scholar 

  • Cabrera-Poch, N., Sanchez-Ruiloba, L., Rodriguez-Martinez, M., and Iglesias, T., 2004, Lipid raft disruption triggers protein kinase C and Src-dependent protein kinase D activation and Kidins220 phosphorylation in neuronal cells, J. Biol. Chem. 279: 28592–28602.

    PubMed  CAS  Google Scholar 

  • Camera, P., Santos Da Silva, J., Griffiths, G., Giuffrida, M., Ferrara, L., Schubert, V., et al., 2003, Citron-N is a neuronal Rho-associated protein involved in Golgi organization through actin cytoskeletal organization, Nat. Cell Biol. 5: 1071–1078.

    PubMed  CAS  Google Scholar 

  • Cao, H., Weller, S., Orth, J.D., Chen, J., Huang, B., Chen, J.L., et al., 2005, Actin and Arf1-dependent recruitment of a cortactin-dynamin complex to the Golgi regulates post-Golgi transport, Nat. Cell Biol. 7: 483–492.

    PubMed  CAS  Google Scholar 

  • Cau, J., and Hall, A., 2005, Cdc42 controls the polarity of the actin and microtubule cytoskeletons through two distinct signal transduction pathways, J. Cell Sci. 118: 2579–2587.

    PubMed  CAS  Google Scholar 

  • Cerione, R., 2004, Cdc42: new roads to travel, Trends Cell Biol. 14: 127–132.

    PubMed  CAS  Google Scholar 

  • Chen, J., Lacomis, L., Erdjument-Bromage, H., Tempst, P., and Stamnes, M., 2004, Cytosol-derived proteins are sufficient for Arp2/3 recruitment and ARF/coatomer-dependent actin polymerization on Golgi membranes, FEBS Lett. 566: 281–286.

    PubMed  CAS  Google Scholar 

  • Chen, J., Fucini, R., Lacomis, L., Erdjument-Bromage, H., Tempst, P., and Stamnes, M., 2005, Coatomer-bound Cdc42 regulates dynein recruitment to COPI vesicles, J. Cell Biol. 169: 383–389.

    PubMed  CAS  Google Scholar 

  • Chieregatti, E., and Meldolesi, J., 2005, Regulated exocytosis: new organelles for non-secretory purposes, Nat. Rev. Mol. Cell Biol. 6: 181–187.

    PubMed  CAS  Google Scholar 

  • Chuang, J., Yen, T., Bollati, F., Conde, C., Canavosio, F., Cáceres, A., et al., 2005, The dynein light chain Tctex-1 has a dynein-independent role in actin remodeling during neurite outgrowth, Dev. Cell 9: 75–86.

    PubMed  CAS  Google Scholar 

  • Cohen, D., Musch, A., and Rodriguez-Boulan, E., 2001, Selective control of basolateral membrane protein polarity by Cdc42, Traffic 2: 556–564.

    PubMed  CAS  Google Scholar 

  • Craig, A., and Banker, G., 1994, Neuronal polarity, Ann. Rev. Neurosci. 17: 267–310.

    PubMed  CAS  Google Scholar 

  • Craig, A., Wyborski, R, and Banker, G., 1995, Preferential addition of newly synthesized membrane protein at axonal growth cones, Nature 375: 592–594.

    PubMed  CAS  Google Scholar 

  • Cruz, J., Tsai, L.-H., 2004, A Jekyll and Hyde kinase: Roles for Cdk5 in brain development and disease, Curr. Opin. Neurobiol. 14: 390–394.

    PubMed  CAS  Google Scholar 

  • Dan, C., Kelly, A., Bernard, O., and Minden, A., 2001, Cytoskeletal changes regulated by the PAK4 serine-threonine kinase are mediated by LIMK1 and cofilin, J. Biol. Chem. 276: 32115–32121.

    PubMed  CAS  Google Scholar 

  • de Anda, F., Pollarolo, G., Da Silva, J., Camoletto, P., Feiguin, F., and Dotti, C., 2005, Centrosome localization determines neuronal polarity, Nature 436: 704–708.

    PubMed  Google Scholar 

  • Dent, E., and Gertler, F., 2003, Cytoskeletal dynamics and transport in growth cone motility and axon guidance, Neuron 40: 209–227.

    PubMed  CAS  Google Scholar 

  • De Hoop, M.J., Huber, L., Stenmark, H., Williamson, E., Zerial, M., Parton, R., et al., 1994, Rab5 involvement in axonal and dendritic endocytosis, Neuron 13: 11–22.

    PubMed  Google Scholar 

  • Dhavan, R., and Tsai, L-H., 2001, A decade of Cdk5, Nature Rev. 2: 749–759.

    CAS  Google Scholar 

  • Dotti, C.G., and Banker, G., 1991, Intracellular organization of hippocampal neurons during the development of neuronal polarity, J. Cell Sci. Suppl. 15: 75–84.

    PubMed  CAS  Google Scholar 

  • Dubois, T., Paleotti, O., Mironov, A., Fraisier, V., Stradal, T., De Matteis, M., et al., 2005, Golgi-localized GAP for Cdc42 functions downstream of ARF1 to control Arp2/3 complex and F-actin dynamics, Nat. Cell Biol. 7: 353–364.

    PubMed  CAS  Google Scholar 

  • Duran, J., Valderrama, F., Castel, S., Magdalena, J., Tomas, M., Hosoya, H., et al., 2003, Myosin motors and not actin comets are mediators of the actin-based Golgi-to-endoplasmic reticulum protein transport, Mol. Biol. Cell. 14: 445–459.

    PubMed  CAS  Google Scholar 

  • Etienne-Manneville, S., and Hall, A., 2001, Integrin-mediated activation of Cdc42 controls cell polarity in migrating astrocytes through PKCzeta, Cell 106: 489–498.

    PubMed  CAS  Google Scholar 

  • Ferreira, A., Niclas, J., Vale, R., Banker, G., and Kosik, K., 1992, Suppression of kinesin expression in cultured hippocampal neurons using antisense oligonucleotides, J. Cell Biol. 117: 595–606.

    PubMed  CAS  Google Scholar 

  • Ferreira, A., Cáceres, A., and Kosik, K., 1993, Intraneuronal compartments of the amyloid precursor protein, J. Neurosci. 13: 3112–3123.

    PubMed  CAS  Google Scholar 

  • Fischer von Mollard, G., Sudhof, T., and Jahn, R., 1991, A small GTP-binding protein dissociates from synaptic vesicles during exocytosis, Nature 349: 79–81.

    PubMed  CAS  Google Scholar 

  • Fucini, R., Navarrete, A., Vadakkan, C., Lacomis, L., Erdjument-Bromage, H., Tempts, P., et al., 2000, Activated ADP-ribosylation factor assembles distinct pools of actin in Golgi membranes, J. Biol. Chem. 275: 18824–18829.

    PubMed  CAS  Google Scholar 

  • Fucini, R., Chen, J., Sharma, C., Kessels, M., and Stamnes, M., 2002, Golgi vesicle proteins are linked to the assembly of an actin complex defined by mAbp1, Mol. Biol. Cell 13: 621–631.

    PubMed  CAS  Google Scholar 

  • Fukata, Y., Itoh, T., Kimura, T., Menager, C., Nishimura, T., Shiromizu, T., et al., 2002, CRMP2 binds to tubulin heterodimers to promote microtubule assembly, Nat. Cell Biol. 4: 583–591.

    PubMed  CAS  Google Scholar 

  • Futerman, A., and Banker, G., 1996, The economics of neurite outgrowth-the addition of new membrane to growing axons, Trends Neurosci. 19: 144–149.

    PubMed  CAS  Google Scholar 

  • Goda, Y., and Davis, G., 2003, Mechanisms of synapse assembly and disassembly, Neuron 40: 243–264.

    PubMed  CAS  Google Scholar 

  • Gomes, E.R., Jani S., Gundersen G.G., 2005, Nuclear movement regulated by Cdc42, MRCK, myosin, and actin flow establishes MTOC polarization in migrating cells, Cell 121: 451–463.

    PubMed  CAS  Google Scholar 

  • Goslin, K., and Banker, G., 1990, Rapid changes in the distribution of GAP-43 correlate with the expression of neuronal polarity during normal development and under experimental conditions, J. Cell Biol. 110: 1319–1331.

    PubMed  CAS  Google Scholar 

  • Gotlieb, A.I., May, L.M., Subrahmanyan, L., and Kalnins, V.I., 1981, Distribution of microtubule organizing centers in migrating sheets of endothelial cells, J. Cell Biol. 91: 589–594.

    PubMed  CAS  Google Scholar 

  • Govek, E., Newey, S., and VanAelst, L., 2005, Role of the GTPases in neuronal development, Gene Dev. 19: 1–49.

    PubMed  CAS  Google Scholar 

  • Gregory, W.A., Edmondson, J.C., Hatten, M.E., and Mason, C.A., 1988, Cytology and neuron-glial apposition of migrating cerebellar granule cells in vitro, J. Neurosci. 8: 1728–1738.

    PubMed  CAS  Google Scholar 

  • Grote, E., and Novick, P., 1999, Promiscuity in Rab-SNARE interactions, Mol. Biol. Cell. 10: 4149–4161.

    PubMed  CAS  Google Scholar 

  • Gundersen, G.G., and Bulinski, J.C., 1988, Selective stabilization of microtubules oriented toward the direction of cell migration, Proc. Natl. Acad. Sci. USA 85: 5946–5950.

    PubMed  CAS  Google Scholar 

  • Heimann, K., Percival, J., Weiberger, R., Gunning, P., and Stow, J., 1999, Specific isoforms of actin-binding protein on distinct populations of Golgi-derived vesicles, J. Biol. Chem. 274: 10743–10750.

    PubMed  CAS  Google Scholar 

  • Hirokawa, N., and Takemura, R., 2005, Molecular motors and mechanisms of directional transport in neurons, Nat. Rev. Neurosci. 6: 201–214.

    PubMed  CAS  Google Scholar 

  • Horton, A., and Ehlers, M., 2003a, Dual modes of endoplasmic reticulum-to-Golgi transport in dendrites revealed by live-cell imaging, J. Neurosci. 23: 6188–6199.

    PubMed  CAS  Google Scholar 

  • Horton A., and Ehlers, M., 2003b, Neuronal polarity and trafficking, Neuron 40: 277–295.

    PubMed  CAS  Google Scholar 

  • Horton, A, and Ehlers, M., 2004, Secretory trafficking in neuronal dendrites, Nat. Cell Biol. 6: 585–591.

    PubMed  CAS  Google Scholar 

  • Horton, A., Racz, B., Monson, E., Lin, A., Weinberg, R., and Ehlers, M., 2005, Polarized secretory trafficking directs cargo for asymmetric dendrite growth and morphogenesis, Neuron 48: 757–771.

    PubMed  CAS  Google Scholar 

  • Huber, L., Dupree, P., and Dotti, C., 1995, A deficiency of the small GTPase rab8 inhibits membrane traffic in developing neurons, Mol. Cell. Biol. 15: 918–924.

    PubMed  CAS  Google Scholar 

  • Itoh, K., Cheng, L., Kamei, Y., Fushiki, S., Kamiguchi, H., Gutwein, P., et al., 2004, Brain development in mice lacking L1–L1 homophilic adhesion, J. Cell Biol. 165: 145–154.

    PubMed  CAS  Google Scholar 

  • Jan, J., and Jan, L., 2003, The control of dendritic development, Neuron 40: 229–242.

    PubMed  CAS  Google Scholar 

  • Jareb, M., and Banker, G., 1997, Inhibition of axonal growth by brefeldin A in hippocampal neurons in culture, J. Neurosci. 17: 8955–8963.

    PubMed  CAS  Google Scholar 

  • Kaether, C., Skehel, P., and Dotti, C., 2000, Axonal membrane proteins are transported in distinct carriers: A two-color video microscopy study in cultured hippocampal neurons, Mol. Biol. Cell 11: 1213–1224.

    PubMed  CAS  Google Scholar 

  • Kamal, A., Stokin, G., Yang, Z., Xia, C., and Goldstein, L.S., 2000, Axonal transport of amyloid precursor protein is mediated by direct binding to the kinesin light chain subunit of kinesin-I, Neuron 28: 449–459.

    PubMed  CAS  Google Scholar 

  • Kamiguchi, H., Hlavin, M., Yamasaki, M., and Lemmon, V., 1998, Adhesion molecules and inherited diseases of the human nervous system, Annu. Rev. Neurosci. 21: 97–125.

    PubMed  CAS  Google Scholar 

  • Kesavapany, S., Lau, K., Ackerley, S., Banner, J., Shemilt, J., Cooper, J., et al., 2003, Identification of a novel, membrane-associated neuronal kinase, cyclin-dependent kinase 5/p35-regulated kinase, J. Neurosci. 23: 4975–4983.

    PubMed  CAS  Google Scholar 

  • Krijnse-Locker, J., Parton, R., Fuller, S., Griffiths, G., and Dotti, C., 1995, The organization of the endoplasmic reticulum and the intermediate compartment in cultured rat hippocampal neurons, Mol. Biol. Cell. 6: 1315–1332.

    PubMed  CAS  Google Scholar 

  • Kroschewski, R., Hall, A., and Mellman, I., 1999, Cdc42 controls secretion and endocytic transport to the basolateral plasma membrane of MDCK cells, Nat. Cell Biol. 1: 8–13.

    PubMed  CAS  Google Scholar 

  • Kupfer, A., Louvard, D., and Singer, S.J., 1982, Polarization of the Golgi apparatus and the microtubule-organizing center in cultured fibroblasts at the edge of an experimental wound, Proc. Natl. Acad. Sci. USA 79: 2603–2607.

    PubMed  CAS  Google Scholar 

  • Kupfer, A., Dennert, G., and Singer, S.J., 1983, Polarization of the Golgi apparatus and the microtubule-organizing center within cloned natural killer cells bound to their targets, Proc. Natl. Acad. Sci. USA 80: 7224–7228.

    PubMed  CAS  Google Scholar 

  • Kunda, P., Paglini, G., Kosik, K., Quiroga, S., and Cáceres, A., 2001, Evidence for the involvement of Tiam-1 in axon formation, J. Neurosci. 21: 2361–2372.

    PubMed  CAS  Google Scholar 

  • Laurino, L., Xiaoxin X., de la Houssaye B., Sosa L., Dupras S., Cáceres A., et al., 2005, PI3K activation by IGF-1 is essential for the regulation of membrane expansion at the nerve growth cone, J. Cell Sci. 118: 3653–3662.

    PubMed  CAS  Google Scholar 

  • Lee, K., Hrosales, J., Tang, D., and Wang, J., 1996, Interaction of cyclin-dependent kinase 5 (Cdk5) and neuronal Cdk5 activator in bovine brain, J. Biol. Chem. 271: 423–426.

    Google Scholar 

  • Lijedahl, M., Maeda, Y., Colanzi, A., Ayala, I., Van Lint, J., and Malhotra, V., 2001, Protein kinase D regulates the fission of cell surface destined transport carriers from the trans-Golgi network, Cell 104: 409–420.

    Google Scholar 

  • Lowenstein, P., Morrison, E., Bain, D., Shering, A., Banting, G., Douglas, P., et al., 1994, Polarized distribution of the trans-Golgi network marker TGN38 during the in vitro development of neocortical neurons: Effects of nocodazole and brefeldin A, Eur. J. Neurosci. 6: 1453–65.

    PubMed  CAS  Google Scholar 

  • Luna, A., Matas, O., Martinez-Menarguez, J., Mato, E., Duran, J., Ballesta, J., et al., 2002, Regulation of protein transport from the Golgi complex to the endoplasmic reticulum by CDC42 and N-WASP, Mol. Biol. Cell. 13: 866–879.

    PubMed  CAS  Google Scholar 

  • Mascotti, F., Cáceres, A., Pfenninger, K., and Quiroga, S., 1997, Expression and distribution of IGF-1 receptors containing a beta-subunit variant (betagc) in developing neurons, J. Neurosci. 17: 1447–1459.

    PubMed  CAS  Google Scholar 

  • Matas, O., Martinez-Menarguez, J., and Egea, G., 2004, Association of Cdc42/N-WASP/Arp2/3 signaling pathway with Golgi membranes, Traffic 5: 838–46.

    PubMed  CAS  Google Scholar 

  • Morfini, G., Rosa, A., Quiroga, S., Kosik, K., and Cáceres, A., 1997, Suppression of KIF2 alters the distribution of a growth cone non-synaptic membrane receptor and inhibits neurite outgrowth, J. Cell Biol. 138: 657–669.

    PubMed  CAS  Google Scholar 

  • Morfini, G., Szebenyi, G., Elluru, R., Ratner, N., and Brady, S.T., 2002, Glycogen synthase kinase-3 phosphorylates kinesin light chains and negatively regulates kinesin-based motility, EMBO J. 23: 281–293.

    Google Scholar 

  • Morfini, G., Szebenyi, G., Brown, H., Pant, H., Pigino, G., DeBoer, S., et al., 2004, A novel CDK5-dependent pathway for regulating GSK3 activity and kinesin-driven motility in neurons, EMBO J. 23: 2235–2245.

    PubMed  CAS  Google Scholar 

  • Musch, A., Cohen, D., Kreitzer, G., and Rodriguez-Boulan, E., 2001, Cdc42 regulates the exit of apical and basolateral proteins from the trans-Golgi network, EMBO J. 20: 2171–2179.

    PubMed  CAS  Google Scholar 

  • Orth, J., and McNiven, M., 2003, Dynamin at the actin-membrane interface, Curr. Opin. Cell Biol. 15: 31–39.

    PubMed  CAS  Google Scholar 

  • Nikolic, M., Chou, M., Lu, W., Mayer, B., and Tsai, L-H., 1998, The p35/Cdk5 kinase is a neuron specific Rac effector and inhibits PAK1 activity, Nature 395: 194–198.

    PubMed  CAS  Google Scholar 

  • Nishimura, T., Yamaguchi, T., Katsukiro, K., Yoshizawa, M., Nabeshima, Y., Ohno, S., et al., 2005, Par6-Par3 mediates Cdc42-induced Rac activation through the Rac GEF STEF/Tiam1, Nat. Cell Biol. 7: 270–277.

    PubMed  CAS  Google Scholar 

  • Paglini, G., and Cáceres, A., 2001, The role of cdk5–p35 kinase in neuronal development, Eur. J. Biochem. 268: 1528–1533.

    PubMed  CAS  Google Scholar 

  • Paglini, G., Pigino, G., Morfini, G., Kunda, P., Maccioni, R., Quiroga, S., et al., 1998, Evidence for the participation of the neuron-specific activator p35 during laminin-enhanced axonal growth, J. Neurosci. 18: 9858–9869.

    PubMed  CAS  Google Scholar 

  • Paglini, G., Peris, L., Diez-Guerra, J., Quiroga, S., and Cáceres, A., 2001a, The Cdk5–p35 kinase associates with the Golgi apparatus and regulates membrane traffic, EMBO Rep. 2: 1139–1144.

    PubMed  CAS  Google Scholar 

  • Palazzo, A.F., Joseph, H.L., Chen, Y.J., Dujardin, D.L., Alberts, A.S., Pfister, K.K., et al., 2001, Cdc42, dynein, and dynactin regulate MTOC reorientation independent of Rho-regulated microtubule stabilization, Curr. Biol. 11: 1536–1541.

    PubMed  CAS  Google Scholar 

  • Pfeffer, S., 1996, Transport vesicle docking: SNAREs and associates, Annu. Rev. Cell Dev. Biol. 12: 441–461.

    PubMed  CAS  Google Scholar 

  • Pfenninger, K.H., and Friedman, L.B., 1993, Sites of plasmalemmal expansion in growth cones, Dev. Brain Res. 71: 181–192.

    CAS  Google Scholar 

  • Pfenninger, K.H., Laurino, L., Peretti, D., Wang, X., Rosso, S., Morfini, G., et al., 2003, Regulation of membrane expansion at the nerve growth cone, J. Cell Sci. 16: 1209–1217.

    Google Scholar 

  • Peretti, D., Peris, L., Rosso, S., Quiroga, S., and Cáceres, A., 2000, Evidence for the involvement of KIF4 in the anterograde transport of L1-containing vesicles, J. Cell Biol. 149: 141–152.

    PubMed  CAS  Google Scholar 

  • Prigozhina, N., and Waterman-Storer, C., 2004, Protein kinase D-mediated anterograde membrane trafficking is required for fibroblast motility, Curr. Biol. 14: 88–98.

    PubMed  CAS  Google Scholar 

  • Qu, J., Li, X., Novitch, B., Zheng, Y., Kohn, M., Xie, J., et al., 2003, PAK4 kinase is essential for embryonic viability and for proper neuronal development, Mol. Cell. Biol. 20: 7122–7133.

    Google Scholar 

  • Quiroga, S., Garofalo, R., and Pfenninger, K., 1995, Insulin-like growth factor I receptors of fetal brain are enriched in nerve growth cones and contain a beta-subunit variant, Proc. Natl. Acad. Sci. USA 92: 4309–4312.

    PubMed  CAS  Google Scholar 

  • Ratner, N., Bloom, G., and Brady, S.T., 1998, A role for Cdk5 kinase in fast anterograde axonal transport: novel effects of olomoucine and the APC tumor suppressor protein, J. Neurosci. 18: 7717–7726.

    PubMed  CAS  Google Scholar 

  • Ridley, A., 2001, Rho proteins: Linking signaling with membrane trafficking, Traffic 2: 303–310.

    PubMed  CAS  Google Scholar 

  • Rosso, S., Bollati, F., Bisbal, M., Peretti, D., Sumi, T., Nakamura, T., et al., 2004, LIMK1 regulates Golgi dynamics, traffic of Golgi-derived vesicles, and process extension in primary cultured neurons, Mol. Biol. Cell 15: 3433–3449.

    PubMed  CAS  Google Scholar 

  • Rothman, J.E., and Warren, G., 1994, Implications of the SNARE hypothesis for intracellular membrane topology and dynamics, Curr. Biol. 4: 220–233.

    PubMed  CAS  Google Scholar 

  • Rozelle, A.L., Machesky, L., Yamamoto, Y., Driessens, M., Insall, R., Roth, M., et al., 2000, Phosphatidylinositol 4, 5 bisphosphate induces actin-based movements of raft-enriched vesicles through WASP-Arp2/3, Curr. Biol. 10: 311–320.

    PubMed  CAS  Google Scholar 

  • Sarmiere, P., and Bamburg, J., 2004, Regulation of the neuronal actin cytoskeleton by ADF/cofilin, J. Neurobiol. 58: 103–117.

    PubMed  CAS  Google Scholar 

  • Shi, S., Jan, L.Y., Jan, N.Y., 2003, Hippocampal neuronal polarity specified by spatially localized mPar3.mPar6 and PI30kinase activity, Cell 112: 63–75.

    PubMed  CAS  Google Scholar 

  • Silverman, M., Kaech, S., Jareb, M., Burack, M., Vogt, L., Sonderegger, P., et al., 2001, Sorting and directed transport of membrane proteins during development of hippocampal neurons in culture, Proc. Natl. Acad. Sci. USA 98: 7051–7057.

    PubMed  CAS  Google Scholar 

  • Simons, K., and Zerial, M., 1993, Rab proteins and the road maps for intracellular transport, Neuron 11: 789–799.

    PubMed  CAS  Google Scholar 

  • Stamnes, M., 2002, Regulating the actin cytoskeleton during vesicular transport, Curr. Opin. Cell Biol. 14: 428–433.

    PubMed  CAS  Google Scholar 

  • Takeda, S., Yamazaki, H., Seog, D., Kanai, Y., Terada, S., and Hirokawa, N., 2000, Kinesin superfamily protein 3 (KIF3) motor transports fodrin-associating vesicles important for neurite building, J. Cell Biol. 148: 1255–1265.

    PubMed  CAS  Google Scholar 

  • Tang, B., 2001, Protein trafficking mechanisms associated with neurite outgrowth and polarized sorting in neurons, J. Neurochem. 79: 923–930.

    PubMed  CAS  Google Scholar 

  • Valderrama, F., Luna, A., Babia, T., Martinez-Menarguez, J., Ballesta, J., Barth, H., et al., 2000, The Golgi-associated COPI-coated buds and vesicles contain beta/gamma –actin, Proc. Natl. Acad. Sci. USA 97: 1560–1565.

    PubMed  CAS  Google Scholar 

  • Valderrama, F., Duran, J., Babia, T., Barth, H., Renau-Piqueras, J., and Egea, G., 2001, Actin microfilaments facilitate the retrograde transport from the Golgi complex to the endoplasmic reticulum in mammalian cells, Traffic 2: 717–726.

    PubMed  CAS  Google Scholar 

  • Van Lint, J., Rykx, A., Maeda, Y., Vantus, T., Sturany, S., Malhotra, V., et al., 2002, Protein kinase D: an intracellular traffic regulator on the move, Trends Cell Biol. 12: 193–200.

    PubMed  Google Scholar 

  • Wang, F., Herzmark, P., Weiner, O.D., Srinivasan, S., Servant, G., and Bourne, H.R., 2002, Lipids products of PI(3) Ks maintain persistent cell polarity and directed motility in neutrophils, Nat. Cell Biol. 4: 509–512.

    Google Scholar 

  • Weiner, O.D., Neilsen, P., Prestwich, G., Kirschner, M., Cantley, L., and Bourne, H.R., 2002, A PtdInsP3- and Rho GTPase-mediated positive feedback loop regulates neutrophil polarity, Nat. Cell Biol. 4: 509–512.

    PubMed  CAS  Google Scholar 

  • Wieland, F., Gleason, M., Serafini, T., and Rothman, J., 1987, The rate of bulk flow from the endoplasmic reticulum to the cell surface. Cell 50: 289–300.

    PubMed  CAS  Google Scholar 

  • Wiggin, R., Fawcett, J., and Pawson, T., 2005, Polarity proteins in axon specification and synaptogenesis, Dev. Cell 8: 803–816.

    PubMed  CAS  Google Scholar 

  • Yeaman, C., Ayala, I., Wright, J., Bard, F., Bossard, C., Ang, A., et al., 2004, Protein kinase D regulates basolateral membrane protein exit from the trans-Golgi network, Nat. Cell Biol. 6: 106–112.

    PubMed  CAS  Google Scholar 

  • Young, Jr., W., Lutz, M., and Blackburn, W., 1992, Endogenous glycosphingolipids move to the cell surface at a rate consistent with bulk flow estimates, J. Biol. Chem. 267: 12011–12015.

    PubMed  CAS  Google Scholar 

  • Zmuda, J., and Rivas, R., 1998, The Golgi apparatus and the centrosome are localized to the sites of newly emerging axons in cerebellar granule neurons in vitro, Cell Motil. Cytosk. 41: 18–38.

    CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2007 Springer Science+Business Media, LLC

About this chapter

Cite this chapter

Cáceres, A., Paglini, G., Quiroga, S., Ferreira, A. (2007). Role of the Golgi Apparatus During Axon Formation. In: de Curtis, I. (eds) Intracellular Mechanisms for Neuritogenesis. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-68561-8_6

Download citation

Publish with us

Policies and ethics