Abstract
Prodrugs are pharmacologically inactive compounds that undergo an in vivo chemical or enzymatic conversion to an active drug molecule to produce a therapeutic effect. An emerging application for prodrug technologies is their use for targeting drugs to specific tissues or cell types. The focus of this chapter is to review the potential use of prodrug technologies in achieving site-specific targeted delivery of drugs and to use computational models to illustrate conditions under which the targeted delivery can be achieved.
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© 2007 American Association of Pharmaceutical Scientists
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Rajewski, R.A., McIntosh, M.P. (2007). Targeting - Theoretical and Computational Models. In: Stella, V.J., Borchardt, R.T., Hageman, M.J., Oliyai, R., Maag, H., Tilley, J.W. (eds) Prodrugs. Biotechnology: Pharmaceutical Aspects, vol V. Springer, New York, NY. https://doi.org/10.1007/978-0-387-49785-3_12
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DOI: https://doi.org/10.1007/978-0-387-49785-3_12
Publisher Name: Springer, New York, NY
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