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The Impact of Psychological Stress on the Immune Response to and Pathogenesis of Herpes Simplex Virus Infection

  • Chapter
Neural and Neuroendocrine Mechanisms in Host Defense and Autoimmunity

Abstract

There is extensive anecdotal evidence supporting an association between psychological stress and one’s susceptibility to a variety of infectious pathogens. These pathogens include a number of viruses with significant short- and long-term health consequences. Infections with one such virus, herpes simplex virus (HSV), have long been recognized to be linked to a variety of life stressors. These HSV infections, both primary and recurrent, have been thought to be, in part, a function of a decreased immune surveillance and a suppression of antiviral immune defense mechanisms. Such stress-induced alterations in immune capacity may be mediated by one or more products of the nervous and endocrine systems.A number of human and animal studies have provided data to support this hypothesis and represent a subset of a larger group of studies that have established a solid link among psychological stress, immune function, and diseases caused by pathogenic microorganisms (reviewed in Moynihan and Ader, 1996; Sheridan et al., 1998; Bonneau et al., 2001; Bailey et al., 2003; Moynihan and Stevens, 2004). Recent advances in experimental immunology have broadened our knowledge of immunological processes that, in turn, have facilitated the design of studies to better examine the interactions among the nervous, endocrine, and immune systems at both the cellular and molecular levels. The information provided in this chapter will review some of the studies that have established a link between stress and HSV, and the impact of this link on human health will be discussed.

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References

  • Ahmed, R. (1994). Viral persistence and immune memory. Semin. Virol. 5:319–324.

    Google Scholar 

  • Anglen, C.S., Truckenmiller, M.E., Schell, T.D., and Bonneau, R.H. (2003). The dual role of CD8+T lymphocytes in the development of stress-induced herpes simplex virus encephalitis. J. Neuroimmunol. 140:13–27.

    PubMed  CAS  Google Scholar 

  • Ashley, R., Wald, A., and Corey, L. (1994). Cervical antibodies in patients with oral herpes simplex virus type-1 (HSV-1) infection: Local anamnestic responses after genital HSV-2 infection. J. Virol. 68:5284–5286.

    PubMed  CAS  Google Scholar 

  • Bailey, M., Engler, H., Hunzeker, J., and Sheridan, J.F. (2003). The hypothalamic-pituitary-adrenal axis and viral infection. Viral Immunol. 16:141–157.

    PubMed  CAS  Google Scholar 

  • Bierman, S.M. (1983). A proposed biologic cure for recurrent genital herpes simplex through injection of neurolytic agents into cutaneous sensory nerves. Med. Hypotheses. 10:97–103.

    PubMed  CAS  Google Scholar 

  • Biron, C.A., Byron, K.S., and Sullivan, J.L. (1989). Severe herpesvirus infections in an adolescent without natural killer cells. N. Engl. J. Med. 320:1731–1735.

    PubMed  CAS  Google Scholar 

  • Block, T.M., and Hill, J.M. (1997). The latency associated transcripts (LAT) of herpes simplex virus: still no end in sight. J. Neurovirol. 3:313–321.

    PubMed  CAS  Google Scholar 

  • Blyth, W.A., and Hill, T.J. (1984). Establishment, maintenance, and control of herpes simplex virus (HSV). Latency. In B.T. Rouse, and C. Lopez (eds.), Immunobiology of Herpes Simplex Virus Infection. Boca Raton, FL: CRC Press, pp. 9–32.

    Google Scholar 

  • Bonneau, R.H. (1996). Stress-induced effects on integral immune components involved in herpes simplex virus (HSV)-specific memory cytotoxic T lymphocyte activation. Brain Behav. Immun. 10:139–163.

    PubMed  CAS  Google Scholar 

  • Bonneau, R.H., and Jennings, S.R. (1989). Modulation of acute and latent herpes simplex virus infection in C57BL/6 mice by adoptive transfer of immune lymphocytes with cytolytic activity. J. Virol. 63:1480–1484.

    PubMed  CAS  Google Scholar 

  • Bonneau, R.H., Sheridan, J.F., Feng, N., and Glaser, R. (1991a). Stress-induced suppression of herpes simplex virus (HSV)-specific cytotoxic T lymphocyte and natural killer cell activity and enhancement of acute pathogenesis following local HSV infection. Brain Behav. Immun. 5:170–192.

    PubMed  CAS  Google Scholar 

  • Bonneau, R.H., Sheridan, J.F., Feng, N., and Glaser, R. (1991b). Stress-induced effects on cell-mediated innate and adaptive memory components of the murine immune response to local and systemic herpes simplex virus (HSV) infection. Brain Behav. Immun. 5:274–295.

    PubMed  CAS  Google Scholar 

  • Bonneau, R.H., Sheridan, J.F., Feng, N., and Glaser, R. (1993). Stress-induced modulation of the primary cellular immune response to herpes simplex virus infection is mediated by both adrenal-dependent and adrenal-independent mechanisms. J. Neuroimmunol. 42:167–176.

    PubMed  CAS  Google Scholar 

  • Bonneau, R.H., Brehm, M.A., and Kern, A.M. (1997). The impact of psychological stress on the efficacy of anti-viral adoptive immunotherapy in an immunocompromised host J. Neuroimmunol. 78:19–33.

    PubMed  CAS  Google Scholar 

  • Bonneau, R.H., Zimmerman, K.M., Ikeda, S.C., and Jones, B.C. (1998), Differential effects of stress-induced adrenal function on components of the herpes simplex virus-specific memory cytotoxic T lymphocyte response. J. Neuroimmunol. 82: 199–207.

    Google Scholar 

  • Bonneau, R.H., Padgett, D.A., and Sheridan, J.F. (2001). Psychoneuroimmune interactions in infectious disease: Studies in animals. In R. Ader, D.L. Felten, and N. Cohen (eds.), Psychoneuroimmunology, 3rd ed. San Diego: Academic Press, pp. 483–497.

    Google Scholar 

  • Brenner, G.J., and Moynihan, J.A. (1997). Stressor-induced alterations in immune response and viral clearance following infection with herpes simplex virus-type 1 in BALB/c and C57BL/6 mice. Brain Behav. Immun. 11:9–23.

    PubMed  CAS  Google Scholar 

  • Brown, Z.A., Benedetti, J., Ashley, R., Burchett, S., Selke, S., Berry, S., Vontver, L.A., and Corey, L. (1991). Neonatal herpes simplex virus infection in relation to asymptomatic maternal infection at the time of labor. N. Engl. J. Med. 324: 1247–1252.

    PubMed  CAS  Google Scholar 

  • Bukowski, J.F., and Welsh, R.M. (1986). The role of natural killer cells and interferon in resistance to acute infection of mice with herpes simplex virus type 1. J. Immunol. 136:3481–3485.

    PubMed  CAS  Google Scholar 

  • Burns, V.E., Drayson, M., Ring, C., and Carroll, D. (2002). Perceived stress and psychological well-being are associated with antibody status after meningitis C conjugate vaccination. Psychosom. Med. 64:963–970.

    PubMed  CAS  Google Scholar 

  • Buske-Kirschbaum, A., Geiben, A., Wermke, C., Pirke, K.M., and Hellhammer, D. (2001). Preliminary evidence for Herpes labialis recurrence following experimentally induced disgust. Psychother. Psychosom. 70:86–91.

    PubMed  CAS  Google Scholar 

  • Carr, D.J., Noisakran, S., Halford, W.P., Lukacs, N., Asensio. V., and Campbell, I.L. (1998). Cytokine and chemokine production in HSV-1 latently infected trigeminal ganglion cell cultures: effects of hyperthermic stress J. Neuroimmunol. 85: 111–121.

    PubMed  CAS  Google Scholar 

  • Cohen, S., Line, S., Manuck, S.B., Rabin, B.S., Heise, E.R., and Kaplan, J.R. (1997). Chronic social stress, social status, and susceptibility to upper respiratory infections in nonhuman primates. Psychosom. Med. 59:213–221.

    PubMed  CAS  Google Scholar 

  • Cohen, S., Doyle, W.J., and Skoner, D.P. (1999). Psychological stress, cytokine production, and severity of upper respiratory illness. Psychosom. Med. 61:175–180.

    PubMed  CAS  Google Scholar 

  • Cruess, S., Antoni, M., Cruess, M., Fletcher, D., Ironson, M.A., Kumar, G., Lutgendorf, M., Hayes, S., Klimas, A., and Schneidermann, N. (2000). Reductions in herpes simplex virus type 2 antibody titers after cognitive behavioral stress management and relationships with neuroendocrine function, relaxation skills, and social support in HIV-positive men. Psychosom. Med. 62:828–837.

    PubMed  CAS  Google Scholar 

  • Daigle, J., and Carr, D.J. (1998). Androstenediol antagonizes herpes simplex virus type 1-induced encephalitis through the augmentation of type I IFN production. J. Immunol. 160:3060–3066.

    PubMed  CAS  Google Scholar 

  • Davis, J.M., Murphy, E.A., Brown, A.S., Carmichael, M.D., Ghaffar, A., and Mayer, E.P. (2004). Effects of oat beta-glucan on innate immunity and infection after exercise stress. Med. Sci. Sports Exerc. 36:1321–1327.

    PubMed  CAS  Google Scholar 

  • de Groot, J., Moonen-Leusen, H.W., Thomas, G., Bianchi, A.T., Koolhaas, J.M., and van Milligen, F.J. (1999a). Effects of mild stress on the immune response against pseudorabies virus in mice. Vet. Immunol. Immunopathol. 67:153–160.

    PubMed  Google Scholar 

  • de Groot, J., van Milligen, F.J., Moonen-Leusen, B.W., Thomas, G., and Koolhaas, J.M. (1999b). A single social defeat transiently suppresses the anti-viral immune response in mice. J. Neuroimmunol. 95:143–151.

    PubMed  Google Scholar 

  • DeLano, R.M., and Mallery, S.R. (1998). Stress-related modulation of central nervous system immunity in a murine model of herpes simplex encephalitis. J. Neuroimmunol. 89:51–58.

    PubMed  CAS  Google Scholar 

  • Dhabhar, F.S., and McEwen, B.S. (1997). Acute stress enhances while chronic stress suppresses cell-mediated immunity in vivo: A potential role for leukocyte trafficking. Brain Behav. Immun. 4:286–306.

    Google Scholar 

  • Dhabhar, F.S., and McEwen, B.S. (1999). Enhancing versus suppressive effects of stress hormones on skin immune function Proc. Natl. Acad. Sci. U.S.A. 96:1059–1064.

    PubMed  CAS  Google Scholar 

  • Dobbs, C.M., Vasquez, M., Glaser, R., and Sheridan, J.F. (1993). Mechanisms of stress-induced modulation of viral pathogenesis and immunity. J. Neuroimmunol. 48:151–160.

    PubMed  CAS  Google Scholar 

  • Dobbs, C.M., Feng, N., Beck, F.M., and Sheridan, J.F. (1996). Neuroendocrine regulation of cytokine production during experimental influenza viral infection: Effects of restraint stress-induced elevation in endogenous corticosterone. J. Immunol. 157:1870–1877.

    PubMed  CAS  Google Scholar 

  • Doherty, P.C., Allan, W., Eichelberger, M., and Carding, S.R. (1992). Roles of α, Β, and γ/δ T cell subsets in viral immunity. Ann. Rev. Immunol. 10:123–151.

    CAS  Google Scholar 

  • Feng, N., Pagniano, R., Tovar, C.A., Bonneau, R.H., Glaser, R., and Sheridan, J.F. (1991). The effect of restraint stress on the kinetics, magnitude, and isotype of the humoral immune response to influenza virus infection. Brain Behav. Immun. 5: 370–382.

    PubMed  CAS  Google Scholar 

  • Friedman, E., Katcher, A.H., and Brightman, V.J. (1977). Incidence of recurrent herpes labialis and upper respiratory infection: A prospective study of the influence of biological, social and psychological predictors. Oral Surg. Oral Med. Oral Pathol. 43:873–878.

    PubMed  CAS  Google Scholar 

  • Glaser, R., and Kiecolt-Glaser, J.K. (1997). Chronic stress modulates the virus-specific immune response to latent herpes simplex virus type 1. Annal. Behav. Med. 19:78–82.

    CAS  Google Scholar 

  • Glaser, R., Kiecolt-Glaser, J.K., Speicher, C.E., and Holliday, J.E. (1985). Stress, loneliness, and changes in herpesvirus latency. J. Behav. Med. 8:249–260.

    PubMed  CAS  Google Scholar 

  • Glaser, R., Rice, J., Sheridan, J., Fertel, R., Stout, J., Speicher, C., Pinsky, D., Kotur, M., Post, A., Beck, M., and Kiecolt-Glaser, J.K. (1987). Stress-related immune suppression: health implications. Brain Behav. Immun. 1:7–20.

    PubMed  CAS  Google Scholar 

  • Glaser, R., Kiecolt-Glaser, J.K., Bonneau, R.H., Malarkey, W., and Hughes, J. (1992). Stress-induced modulation of the immune response to recombinant hepatitis B vaccine. Psychosom. Med. 54:22–29.

    PubMed  CAS  Google Scholar 

  • Glaser, R., Sheridan, J.F., Malarkey, W.B., MacCallum, R.C., and Kiecolt-Glaser, J.K. (2000). Chronic stress modulates the immune response to a pneumococcal pneumonia vaccine. Psychosom. Med. 62:804–807.

    PubMed  CAS  Google Scholar 

  • Gray, D. (1993). Immunological memory. Ann. Rev. Immunol. 11:49–77.

    CAS  Google Scholar 

  • Harbour, D.A., Hill, T.J., and Blyth, W.A. (1983). Recurrent herpes simplex in the mouse: Inflammation in the skin and activation of virus in the ganglia following peripheral stimulation. J. Gen. Virol. 64:1491–1498.

    PubMed  Google Scholar 

  • Hermann, G., Tovar, C.A., Beck, F.M., Allen, C., and Sheridan, J.F. (1993). Restraint stress differentially affects the pathogenesis of an experimental influenza viral infection in three inbred strains of mice. J. Neuroimmunol. 47:83–94.

    PubMed  CAS  Google Scholar 

  • Hermann, G., Tovar, C.A., Beck, F.M., and Sheridan, J.F. (1994a). Kinetics of glucocorticoid response to restraint stress and/or experimental influenza viral infection in two inbred strains of mice. J. Neuroimmunol. 49:25–33.

    PubMed  CAS  Google Scholar 

  • Hermann, G., Beck, F.M., Tovar, C.A., Malarkey, W.B., Allen, C., and Sheridan, J.F. (1994b). Stress-induced changes attributable to the sympathetic nervous system during experimental influenza viral infection in DBA/2 inbred mouse strain. J. Neuroimmunol. 53:173–180.

    PubMed  CAS  Google Scholar 

  • Hermann, G., Beck, F.M., and Sheridan, J.F. (1995). Stress-induced glucocorticoid response modulates mononuclear cell trafficking during an experimental influenza viral infection. J. Neuroimmunol. 56:179–186.

    PubMed  CAS  Google Scholar 

  • Hill, T.J. (1985). Herpes simplex virus latentcy. In B. Roizman (ed.), The Herpesviruses. New York: Plenum, pp. 175–240.

    Google Scholar 

  • Hill, T.J., Blyth, W.A., and Harbour, D.A. (1978). Trauma to the skin causes recurrence of herpes simplex in the mouse. J. Gen. Virol. 39:21–28.

    PubMed  CAS  Google Scholar 

  • Holland, D.J., Miranda-Saksena, M., Boadle, R.A., Armati, P., and Cunningham, A.L. (1999). Anterograde transport of herpes simplex virus proteins in axons of peripheral human fetal neurons: an immunoelectron microscopy study. J. Virol. 73:8503–8511.

    PubMed  CAS  Google Scholar 

  • Hunzeker, J., Padgett, D.A., Sheridan, P.A., Dhabhar, F.S., and Sheridan, J.F. (2004). Modulation of natural killer cell activity by restraint stress during an influenza A/PR8 infection in mice. Brain Behav. Immun. 18:526–535.

    PubMed  CAS  Google Scholar 

  • Hurd, J., and Robinson, T.W. (1977). Herpes virus reactivation in a mouse model. J. Antimicrob. Chemother. 3:99–106.

    PubMed  Google Scholar 

  • Johnson, R.R., Storts, R., Welsh, T.H., Jr., Welsh, C.J., and Meagher, M.W. (2004). Social stress alters the severity of acute Theiler’s virus infection. J. Neuroimmunol. 148:74–85.

    PubMed  CAS  Google Scholar 

  • Jones, C. (2003). Herpes simplex virus type 1 and bovine herpesvirus 1 latency. Clin. Microbiol. Rev. 6:79–95.

    Google Scholar 

  • Karp, J.D., Moynihan, J.A., and Ader, R. (1997). Psychosocial influences on immune responses to HSV-1 infection in BALB/c mice. Brain Behav. Immun. 11:47–62.

    PubMed  CAS  Google Scholar 

  • Katcher, A.H., Brightman, V., Luborsky, L., and Ship, I. (1973). Prediction of the incidence of recurrent herpes labialis and systemic illness from psychological measurements. J. Dent. Res. 52:49–58.

    PubMed  CAS  Google Scholar 

  • Khanna, K.M., Bonneau, R.H., Kinchington, P.R., and Hendricks, R.L. (2003). Herpes simplex virus-specific memory CD8+ T cells are selectively activated and retained in latently infected sensory ganglia. Immunity 18:593–603.

    PubMed  CAS  Google Scholar 

  • Khanna, K.M., Lepisto, A.J., Decman, V., and Hendricks, R.L. (2004). Immune control of herpes simplex virus during latency. Curr. Opin. Immunol. 16:463–469.

    PubMed  CAS  Google Scholar 

  • Kiecolt-Glaser, J.K., Glaser, R., Gravenstein, S., Malarkey, W.B., and Sheridan, J. (1996). Chronic stress alters the immune response to influenza virus vaccine in older adults. Proc. Nat. Acad. Sci. U.S.A. 93:3043–3047.

    CAS  Google Scholar 

  • Koelle, D.M., and Corey, L. (2003). Recent progress in herpes simplex virus immunobiology and vaccine research. Clin. Microbiol. Rev. 16:96–113.

    PubMed  CAS  Google Scholar 

  • Koelle, D.M., Posavad, C.M., Barnum, G.R., Johnson, M.L., Frank, J.M., and Corey, L. (1998). Clearance of HSV-2 from recurrent genital lesions correlates with infiltration of HSV-specific cytotoxic T lymphocytes. J. Clin. Invest. 101:1500–1508.

    PubMed  CAS  Google Scholar 

  • Koff, W.C., and Dunegan, M.A. (1986). Neuroendocrine hormones suppress macrophage-mediated lysis of herpes simplex virus-infected cells. J. Immun. 136: 705–709.

    PubMed  CAS  Google Scholar 

  • Konstantinos, A.P., and Sheridan, J.F. (2001). Stress and influenza viral infection: Modulation of proinflammatory cytokine responses in the lung. Respir. Physiol. 128:71–77.

    PubMed  CAS  Google Scholar 

  • Kriesel, J.D., Gebhardt, B.M., Hill, J.M., Maulden, S.A., Hwang, I.P., Clinch, T.E., Cao, X., Spruance, S.L., and Araneo, B.A. (1997). Anti-interleukin-6 antibodies inhibit herpes simplex virus reactivation. J. Infect. Dis. 175:821–827.

    PubMed  CAS  Google Scholar 

  • Kusnecov, A.V., Grota, L.J., Schmidt, S.G., Bonneau, R.H., Sheridan, J.F., Glaser, R., and Moynihan, J.A. (1992) Decreased herpes simplex virus immunity and enhanced pathogenesis following stressor administration in mice. J. Neuroimmunol. 38:129–138.

    PubMed  CAS  Google Scholar 

  • Leo, N.A., and Bonneau, R.H. (2000a). Chemical sympathectomy alters cytotoxic T lymphocyte responses to herpes simplex virus infection. Ann. N.Y. Acad. Sci. 840: 803–808.

    Google Scholar 

  • Leo, N.A., and Bonneau, R.H. (2000b). Mechanisms underlying chemical sympathectomy-induced suppression of herpes simplex virus-specific cytotoxic T lymphocyte activation and function. J. Neuroimmunol. 110:45–56.

    PubMed  CAS  Google Scholar 

  • Leo, N.A., Callahan, T.A., and Bonneau, R.H. (1998). Peripheral sympathetic denervation alters both the primary and memory cellular immune response to herpes simplex virus infection. Neuroimmunomodulation 5:22–35.

    PubMed  CAS  Google Scholar 

  • Liu, T., Khanna, K.M., Chen, X., Fink, D.J., and Hendricks, R.L. (2000). CD8(+) T cells can block herpes simplex virus type 1 (HSV-1) reactivation from latency in sensory neurons. J. Exp. Med. 191:1459–1466.

    PubMed  CAS  Google Scholar 

  • Longo, D.J., and Clum, G.A. (1989). Psychosocial factors affecting genital herpes recurrences: Linear vs mediating models. J. Psychosom. Res. 33:161–166.

    PubMed  CAS  Google Scholar 

  • Mackay, C.R. (1993). Immunological memory. Adv. Immunol. 53:217–265.

    PubMed  CAS  Google Scholar 

  • Mi, W., Belyavskyi, M., Johnson, R.R., Sieve, A.N., Storts, R., Meagher, M.W., and Welsh, C.J. (2004). Alterations in chemokine expression following Theiler’s virus infection and restraint stress. J. Neuroimmunol. 151:103–115.

    PubMed  CAS  Google Scholar 

  • Miller, G.E., Cohen, S., Pressman, S., Barkin, A., Rabin, B.S., and Treanor J.J. (2004). Psychological stress and antibody response to influenza vaccination:When is the critical period for stress, and how does it get inside the body? Psychosom. Med. 66:215–223.

    PubMed  Google Scholar 

  • Morahan, P.S., and Morse, S. (1979). Macrophage-virus interactions. In M. Proffitt (ed.), Virus-Lymphocyte Interactions: Implications for Disease. New York: Elsevier, pp. 17–35.

    Google Scholar 

  • Moynihan, J.A., and Ader, R. (1996). Psychoneuroimmunology: Animal models of disease. Psychosom. Med. 58:546–558.

    PubMed  CAS  Google Scholar 

  • Moynihan, J.A., and Stevens, S.Y. (2001). Mechanisms of stress-induced modulation in animals In R. Ader, D.L. Felten, and N. Cohen (eds.), Psychoneuroimmunology, 3rd ed., San Diego: Academic Press, pp. 227–250.

    Google Scholar 

  • Nair, A., and Bonneau, R.H. (2006). Stress-induced elevation of glucocorticoids increases microglia proliferation through NMDA receptor activation. J. Neuroimmunol, 171:72–85.

    PubMed  CAS  Google Scholar 

  • Noisakran, S., Halford, W.P., and Carr, D.J. (1998). Role of the hypothalamic pituitary adrenal axis and IL-6 in stress-induced reactivation of latent herpes simplex virus type 1. J. Immunol. 160:5441–5447.

    PubMed  CAS  Google Scholar 

  • Ortiz, G.C., Sheridan, J.F., and Marucha, P.T. (2003). Stress-induced changes in pathophysiology and interferon gene expression during primary HSV-1 infection. Brain Behav. Immun. 17:329–338.

    PubMed  CAS  Google Scholar 

  • Padgett, D.A., Sheridan, J.F., Dorne, J., Berntson, G.G., Candelora, J., and Glaser, R. (1998a). Social stress and the reactivation of latent herpes simplex virus type 1. Proc. Natl. Acad. Sci. U. S. A. 95:7231–7235.

    PubMed  CAS  Google Scholar 

  • Padgett, D.A., MacCallum, R.C., and Sheridan, J.F. (1998b). Stress exacerbates agerelated decrements in the immune response to an experimental influenza viral infection. J. Gerontol. A. Biol. Sci. Med. Sci. 53:B347–353.

    PubMed  CAS  Google Scholar 

  • Pamer, E.G. (1993). Cellular immunity to intracellular bacteria. Curr. Opin. Immunol. 5:492–496.

    PubMed  CAS  Google Scholar 

  • Pariante, C.M., Carpiniello, B., Orru, M.G., Sitzia, R., Piras, A., Farci, A.M., DelGiacco, G.S., Piludu, G., and Miller, A. H. (1997). Chronic caregiving stress alters peripheral blood immune parameters:The role of age and severity of stress. Psychother. Psychosom. 66:199–207.

    PubMed  CAS  Google Scholar 

  • Pereira, D.B., Antoni, M.H., Danielson, A., Simon, T., Efantis-Potter, J., Carver, C.S., Duran, R.E., Ironson, G., Klimas, N., Fletcher, M.A., and O’Sullivan, M.J. (2003). Stress as a predictor of symptomatic genital herpes virus recurrence in women with human immunodeficiency virus. J. Psychosom. Res. 54:237–244.

    PubMed  Google Scholar 

  • Pinto, A.J., Stewart, D., van Rooijen, N., and Morahan, P.S. (1991). Selective depletion of liver and splenic macrophages using liposomes encapsulating the drug dichloromethylene diphosphonate: Effects on antimicrobial resistance. J. Leukoc. Biol. 49:579–586.

    PubMed  CAS  Google Scholar 

  • Ramsey, J.M. (1982). Basic Pathophysiology: Modern Stress and the Disease Process. Menlo Park, CA; Addison-Wesley, pp. 30–73.

    Google Scholar 

  • Rasmussen, A.F., Marsh, J.T., and Brill, N.O. (1957). Increased susceptibility to herpes simplex in mice subjected to avoidance-learning stress or restraint. Proc. Soc. Exp. Biol. Med. 96:183–189.

    PubMed  Google Scholar 

  • Rinaldo, C.R., and Torpey, D.J. (1993). Cell-mediated immunity and immunosuppression in herpes simplex virus infection. Immunodeficiency. 5:33–90.

    PubMed  Google Scholar 

  • Sawtell, N.M., and Thompson, R.L. (1992). Rapid in vivo reactivation of herpes simplex virus type 1 in latently infected murine ganglionic neurons after transient hyperthermia. J. Virol. 66:2150–2156.

    PubMed  CAS  Google Scholar 

  • Sawtell, N.M. (1998). The probability of in vivo reaction herpes simplex virus type 1 increases with the number of latently infected neurons in the ganglia. J. Virol. 72:6888–6892.

    PubMed  CAS  Google Scholar 

  • Schmid, D.S., and Rouse, B.T. (1992). The role of T cell immunity in control of herpes simplex virus. Curr. Top. Microbiol. Immunol. 179:57–74.

    PubMed  CAS  Google Scholar 

  • Schmidt, D.D., Zyzanski, S., Ellner, J., Kumar, M.L., and Arno, J. (1985). Stress as a precipitating factor in subjects with recurrent herpes labialis. J. Fam. Pract. 20: 359–366.

    PubMed  CAS  Google Scholar 

  • Sher, A., and Coffman, R.L. (1992). Regulation of immunity to parasites by T cells and T cell-derived cytokines. Ann. Rev. Immunol. 10:385–409.

    CAS  Google Scholar 

  • Sheridan, J.F., Feng, N.G., Bonneau, R.H., Allen, C.M., Huneycutt, B.S., and Glaser, R. (1991). Restraint stress differentially affects anti-viral cellular and humoral immune responses in mice. J. Neuroimmunol. 31:245–255.

    PubMed  CAS  Google Scholar 

  • Sheridan, J.F., Dobbs, C., Jung, J., Chu, X., Konstantinos, A., Padgett D., and Glaser R. (1998). Stress-induced neuroendocrine modulation of viral pathogenesis and immunity. Ann. N.Y. Acad. Sci. 840:803–808.

    PubMed  CAS  Google Scholar 

  • Sheridan, J.F., Stark, J.L., Avitsur, R., and Padgett, D.A. (2000). Social disruption, immunity, and susceptibility to viral infection. Role of glucocorticoid insensitivity and NGF. Ann. N.Y. Acad. Sci. 917:894–905.

    PubMed  CAS  Google Scholar 

  • Sieve, A.N., Steelman, A.J., Young, C.R., Storts, R., Welsh, T.H., Welsh, C.J., and Meagher, M.W. (2004). Chronic restraint stress during early Theiler’s virus infection exacerbates the subsequent demyelinating disease in SJL mice. J. Neuroimmunol. 155:103–118.

    PubMed  CAS  Google Scholar 

  • Silver, P.S., Auerbach, S.M., Vishniavsky, N., Kaplowitz, L.G. (1986). Psychological factors in recurrent genital herpes infection: stress, coping style, social support, emotional dysfunction, and symptom recurrence. J. Psychosom. Res. 30:163–171.

    PubMed  CAS  Google Scholar 

  • Sprent, J. (1994). T and B memory cells. Cell 76:315–322.

    PubMed  CAS  Google Scholar 

  • Stout, C.W., and Bloom L.J. (1986). Genital herpes and personality. J. Human Stress 12:119–124.

    PubMed  CAS  Google Scholar 

  • Stevens, J.G. (1975). Latent herpes simplex virus and the nervous system. Curr. Top. Microbiol. Immunol. 70:31–50.

    PubMed  CAS  Google Scholar 

  • Thompson, R.L., and Sawtell, N.M. (1997). The herpes simplex virus and type 1 latency-associated transcript gene regulates the establishment of latency. J. Virol. 71:5432–5440.

    PubMed  CAS  Google Scholar 

  • Truckenmiller, M.E., Princiotta, M.F., Norbury, C.C., and Bonneau, R.H. (2005). Corticosterone impairs MHC class I antigen presentation by dendritic cells via reduction of peptide generation. J. Neuroimmunol. 160:48–60.

    PubMed  CAS  Google Scholar 

  • Vedhara, K. Cox, N.K., Wilcock, G.K., Perks, P., Hunt, M., Anderson, S., Lightman, S.L., Shanks, N.M. (1999). Chronic stress in elderly caregivers of dementia patients and antibody response to influenza vaccination. Lancet 353:627–631.

    PubMed  CAS  Google Scholar 

  • Wald, A., Zeh, J., Selke, S., Ashley, R.L., and Corey, L. (1995). Virologic characteristics of subclinical and symptomatic genital herpes infections. N. Engl. J. Med. 333: 770–775.

    PubMed  CAS  Google Scholar 

  • Wald, A., Corey, L., Cone, R., Hobson, A., Davis, G., and Zeh, J. (1997). Frequent genital herpes simplex virus 2 shedding in immunocompetent women: Effect of acyclovir treatment. J. Clin. Invest. 99:1092–1097.

    PubMed  CAS  Google Scholar 

  • Welsh, C.J., Bustamante, L., Nayak, M., Welsh, T.H., Dean, D.D., and Meagher, M.W. (2004). The effects of restraint stress on the neuropathogenesis of Theiler’s virus infection II: NK cell function and cytokine levels in acute disease. Brain Behav. Immun. 18:166–174.

    PubMed  CAS  Google Scholar 

  • Wonnacott, K.M., and Bonneau, R.H. (2002). The effects of stress on memory cytotoxic T lymphocyte (CTLm)-mediated protection against herpes simplex virus (HSV) infection at mucosal sites. Brain Behav. Immun. 16:104–117.

    PubMed  CAS  Google Scholar 

  • Yorty, J.L., and Bonneau, R.H. (2003). Transplacental transfer and subsequent neonate utilization of herpes simplex virus-specific immunity is resilient to acute maternal stress. J. Virol. 77:6613–6619.

    PubMed  CAS  Google Scholar 

  • Yorty, J.L., and Bonneau, R.H. (2004a). Prenatal transfer of low amounts of herpes simplex virus (HSV)-specific antibody protects newborn mice against HSV infection during acute maternal stress. Brain Behav. Immun. 18:15–23.

    PubMed  CAS  Google Scholar 

  • Yorty, J.L., and Bonneau, R.H. (2004b). The impact of maternal stress on the transmammary transfer and protective capacity of herpes simplex virus-specific immunity. Am. J. Physiol. Regul. Integr. Comp. Physiol. 287:R1316–1324.

    PubMed  CAS  Google Scholar 

  • Yorty, J.L. Schultz, S.A., and Bonneau, R.H. (2004). Postpartum maternal corticosterone decreases maternal and neonatal antibody levels and increases susceptibility of newborn mice to herpes simplex virus-associated mortality. J. Neuroimmunol. 150:48–58.

    PubMed  CAS  Google Scholar 

  • Young, E.J., Killam, A.P., and Greene, J.F., Jr. (1976). Disseminated herpesvirus infection. Association with primary genital herpes in pregnancy. JAMA 235: 2731–2733.

    PubMed  CAS  Google Scholar 

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Authors
  1. Robert H. Bonneau
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  2. John Hunzeker
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Editor information

Editors and Affiliations

  1. Departments of Veterinary Integrative Biosciences and Veterinary Pathobiology College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX, 77843-4458

    C. Jane Welsh

  2. Department of Psychology College of Liberal Arts, Texas A&M University, College Station, TX, 77843-4225

    Mary W. Meagher

  3. Section on Neuroendocrine Immunology and Behavior, National Institute of Mental Health National Institutes of Health, Rockville, MD, 20892-9401

    Esther M. Sternberg

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© 2006 Springer Science+Business Media, LLC

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Bonneau, R.H., Hunzeker, J. (2006). The Impact of Psychological Stress on the Immune Response to and Pathogenesis of Herpes Simplex Virus Infection. In: Welsh, C.J., Meagher, M.W., Sternberg, E.M. (eds) Neural and Neuroendocrine Mechanisms in Host Defense and Autoimmunity. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-48334-4_7

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