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Mechanisms of Activation and Regulation of the Heat Shock-Sensitive Signaling Pathways

  • Chapter
Molecular Aspects of the Stress Response: Chaperones, Membranes and Networks

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 594))

Abstract

Heat shock (HS), like many other stresses, induces specific and highly regulated signaling cascades that promote cellular homeostasis. The three major mitogen-activated protein kinases (MAPK) and protein kinase B (PKB/Akt) are the most notable of these HS-stimulated pathways. Their activation occurs rapidly and sooner than the transcriptional upregulation of heat shock proteins (Hsp), which generate a transient state of extreme resistance against subsequent thermal stress. The direct connection of these signaling pathways to cellular death or survival mechanisms suggests that they contribute importantly to the HS response. Some of them may counteract early noxious effects of heat, while others may bolster key apoptosis events. The triggering events responsible for activating these pathways are unclear. Protein denaturation, specific and nonspecific receptor activation, membrane alteration and chromatin structure perturbation are potential initiating factors.

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Authors and Affiliations

  1. Centre de recherche en cancérologie de l’Université Laval, L’Hôtel-Dieu de Québec, 9, rue McMahon, Québec, Canada, 1R 2J6

    Jacques Landry

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  1. Sébastien Ian Nadeau
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  2. Jacques Landry
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Correspondence to Jacques Landry .

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  1. Department of Medical Chemistry, Semmelweis University, Budapest, Hungary

    Peter Csermely

  2. Institute of Biochemistry, Biological Research Center of the Hungarian Academy of Sciences, Szeged, Hungary

    László Vígh

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Nadeau, S.I., Landry, J. (2007). Mechanisms of Activation and Regulation of the Heat Shock-Sensitive Signaling Pathways. In: Csermely, P., Vígh, L. (eds) Molecular Aspects of the Stress Response: Chaperones, Membranes and Networks. Advances in Experimental Medicine and Biology, vol 594. Springer, New York, NY. https://doi.org/10.1007/978-0-387-39975-1_10

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