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σ Receptors: Historical Perspective and Background

  • Chapter
Sigma Receptors

Summary

The early history of σ receptors is characterized by classical pharmacological approaches which succeeded in defining a unique drug selectivity pattern and anatomical distribution for these proteins. σ Receptors are widely distributed in the body, where they mediate a variety of physiological functions. The chemical diversity of compounds that interact with σ receptors is vast and includes therapeutically relevant entities including psychotomimetic opiates, neuroleptics, antihistamines, and antidepressants. The recent revolution in molecular biology has provided additional information about σ receptors, including the sequence of one of its major subtypes and a host of experimental tools to aid in selectively deciphering its functions. We now know that σ receptors have important implications for a number of disease states and mounting evidence indicates that they are viable therapeutic targets for medication development. The remaining chapters in this book summarize our current knowledge regarding the medicinal chemistry, cell biological and clinical implications of σ receptors. It is hoped that this information will lay the groundwork for innovative future studies to stimulate new insights into the physiological and therapeutic relevance of σ receptors.

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  1. Department of Pharmacology, University of Mississippi, Oxford, MS 38677, USA

    Dr. Rae R. Matsumoto

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  1. National Institute on Drug Abuse, Bethesda, MD

    Tsung-Ping Su

  2. University of Mississippi, University, MS

    Rae R. Matsumoto

  3. Brown University, Providence, RI

    Wayne D. Bowen

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Matsumoto, R.R. (2007). σ Receptors: Historical Perspective and Background. In: Su, TP., Matsumoto, R.R., Bowen, W.D. (eds) Sigma Receptors. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-36514-5_1

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